ABSTRACT
The paper deals with the peculiarities of formation, clinical presentations and therapy of diffuse nontoxic goiter of children. The paper highlights the connection of the disease with the genetic predisposition, the impact of natural and anthropogenic strumagenes, immune processes. The clinical presentations of the diffuse nontoxic goiter are diffuse enlargement of thyroid gland, normal or high level of thyrotropichypophysis hormone when the content of thyroxin and triiodothyronine is normal, which is treated as the subclinic hypothyroidism syndrome. The variety of the disease pathogenesis theories leads to testing of different therapeutic methods, the principal ones among them are the use of iodine preparation and replacement therapy.
Subject(s)
Goiter, Endemic/therapy , Goiter, Nodular/therapy , Hormone Replacement Therapy , Pituitary Gland/drug effects , Thyroid Gland/drug effects , Child , Female , Genetic Predisposition to Disease , Goiter, Endemic/genetics , Goiter, Endemic/physiopathology , Goiter, Nodular/genetics , Goiter, Nodular/physiopathology , Humans , Iodine Compounds/administration & dosage , Male , Pituitary Gland/metabolism , Pituitary Gland/physiopathology , Sex Factors , Thyroid Gland/metabolism , Thyroid Gland/physiopathology , Thyrotropin/metabolism , Thyroxine/administration & dosage , Thyroxine/metabolism , Triiodothyronine/metabolismABSTRACT
The paper deals with etiopathogenetic and clinical peculiarities, and also therapeutic methods during the pathological processes in the thyroid system in the childhood. The most common of these processes is the diffuse nontoxic goiter, which results in abnormality of metabolic processes regulation in the child's growing organism and often signals to the beginning of many thyropathies.
