[Effect of the rheological properties of the blood on the intracardiac hemodynamics in patients with acquired mitral valve defects]. / Vliianie reologicheskikh svoistv krovi na vnutriserdechnuiu gemodinamiku u bol'nykh priobretennymi mitral'nymi porokami serdtsa.

A study of 17 patients with prevailing mitral stenosis and 10 patients with prevailing mitral insufficiency demonstrated a significant aspirin-induced improvement of blood rheologic characteristics in all patients that was accompanied with a heterogeneous shift of intracardiac hemodynamics and left-ventricular myocardial pumping activity. For instance, in patients with prevailing mitral stenosis, an improvement of blood rheologic properties is accompanied with a drop in mitral pressure gradient and a decrease in total pulmonary resistance and total peripheral resistance resulting in increased pumping capacity of the heart (increased minute volume, systolic index and stroke index). In patients with prevailing mitral insufficiency, the improvement of blood rheologic properties is accompanied by an increase of regurgitation volume, a reduction of effective ejection fraction and a rise in total pulmonary resistance. Therefore, a differential approach to the use of agents improving blood rheologic properties is needed.

[Effect of reflexotherapy on the baroreflex function of patients with neurocirculatory dystonia and the initial stages of hypertension]. / Vliianie refleksoterapii na sostoianie baroreflektornoi funktsii u bol'nykh s neirotsirkuliatornoi distoniei i nachal'nymi stadiiami gipertonicheskoi bolezni.

Central and peripheral hemodynamic effects of reflex therapy were assessed by means of echocardiography and rheovasography, as was the pulse rate, arterial blood pressure and peripheral vascular tonicity response to the baroreflex test in patients with neurocirculatory dystonia, the hypertensive syndrome and essential hypertension, stage IB-HA by L. A. Miasnikov's classification. The hypotensive effect and favorable central hemodynamic changes contribute to the recovery of an adequate pulse and blood pressure response to the baroreflex test, and a greater baroreflex test-induced drop in vascular tone.

[Clinical pharmacology of the new Soviet anti-inflammatory preparation ortofen]. / Klinicheskaia farmakologiia novogo otechesvennogo protivovospalitel'nogo preparata ortofena.

Comparative pharmacokinetic and pharmacodynamic studies on ortophen, a new Soviet antiinflammatory drug, and voltaren (Ciba-Geigy, Switzerland) were carried out in 73 patients with rheumatoid arthritis. Pharmacokinetics of both drugs was studied in 19 patients (9 patients were given voltaren, 10--ortophen). Pharmacokinetic difference was statistically indistinguishable. The comparison of the principal routine subjective and objective pharmacodynamic indices revealed no significant difference between ortophen and voltaren action. The new drug was shown to possess a high analgetic and antiinflammatory activity.

[Early diagnosis of left-ventricular hypertrophy using precordial electrocardiographic mapping of the heart]. / Ranniaia diagnostika gipertrofii levogo zheludochka s pomoshch'iu prekordial'nogo elektrokardiograficheskogo kartirovaniia serdtsa.

Quantitative indices of instantaneous maps of the distribution of electric potential on the chest surface were compared to a left ventricular myocardial mass value, calculated on the basis of echocardiographic results and echocardiographic signs of left ventricular hypertrophy, in 77 patients with essential hypertension or neurocirculatory dystonia of hypertensive type and in 25 healthy controls. Four quantitative cartographic indices were shown to be very important for diagnosis: 1) tMaxk; 2) tapic; 3) + sigma QRS; 4) NQ15. The sensitivity, specificity and accuracy of diagnosis of left ventricular hypertrophy was over 80%. Cartographic quantitative indices were shown to correlate with a high degree of significance (p less than 0.01) (r much greater than 0.75) with a left ventricular myocardial mass value calculated on the basis of echocardiography results.

[Immunochemical identification and physicochemical study of the alpha 2-glycoprotein from atherosclerotically altered aortic wall]. / Immunokhimicheskaia identifikatsiia i fiziko-khimicheskoe izuchenie al'fa 2-glikoproteida ateroskleroticheski izmenennoi stenki aorty.

An antigen similar in its mobility to alpha 2-globulins has been isolated from atherosclerotic aortic wall. This antigen was undetectable in other tissues by immunodiffusion technique. The antigen was identified as alpha 2-glycoprotein of an atherosclerotic aortic wall, its molecular mass was 80,000 +/- 10,000 D. Amino-acid analysis has shown predominance of glutamic acid and proline in the molecular protein. The antigen was detected in the blood serum of atherosclerotic patients by immunodiffusion technique.

[Changes in blood immunochemical indices in atherosclerosis patients during combined diet and drug therapy]. / Izmeneniia immunokhimicheskikh pokazatelei krovi u bol'nykh aterosklerozom v protsesse kompleksnoi dietomedikamentoznoi terapii.

A total of 34 patients with atherosclerosis were on a prolonged combined dietetic and drug therapy. In 6 mos improved blood serum lipid indices (a decrease in the level of total cholesterol, a decrease in the level of atherogenic beta-lipoproteins and an increase in the level of antiatherogenic alpha 1-lipoproteins) and a decrease in the serum level of alpha 2-glycoproteins of the atherosclerotically changed aortic wall were observed. A decrease in angina attacks, AP stabilization, disappearance of dyspnea in physical exercise, and a decrease in excess body mass were noted. The authors emphasized the efficacy of this method for the treatment of patients with atherosclerosis.

[Experience with the treatment of duodenal ulcer using H2-histamine receptor blockers]. / Opyt lecheniia iazvennoi bolezni dvenadtsatiperstnoi kishki blokatorami H2-gistaminovykh retseptorov.

The authors compared the efficacy of the blockers of H2-histamine receptors with the conventional multimodality treatment in patients with peptic ulcer of the duodenum and explored the effect of cimetidine on the secretory and motor functions of the stomach and on the endocrine status of the patients. It was established that cimetidine made the healing of duodenal ulcers more rapid as compared with the use of the multimodality therapy. It was also found that the drug efficacy was mainly related to the suppression of hydrochloric acid secretion in the stomach and to the recovery of motor activity of the stomach and duodenum. It is demonstrated that cimetidine has a broad-range action on the endocrine system, which should be taken into consideration in administering cimetidine.

[Gastrointestinal endocrine cells in metaplasia of the gastric mucosa and duodenum]. / Gastrointestinal'nye éndokrinnye kletki pri metaplazii slizistoi obolochki zheludka i dvenadtsatiperstnoi kishki.

Grimelius reaction and immunohistochemical PAP method were used to study endocrine cells producing gastrin (G-cells), somatostatin (D-cells) and gamma-endorphin (GER-cells) in gastric and duodenal mucosa of 95 males with atrophic gastritis with intestinal and pyloric metaplasia. The number of cells was counted per 1 mm2 of the mucosa. In the cases of marked intestinal metaplasia the number of G-, GER- and especially D-cells in the pyloric region non-metaplastic epithelium decreases and is approaching to its number in the duodenum of the control group. In the foci of marked pyloric metaplasia of gastric corpus the number of G- and GER-cells is almost the same as in the zones of gastric metaplasia of duodenum, and is approximating their number in the pyloric region of controls, thus allowing the designation of pyloric metaplasia as a complete one.

[Relation between features of the psychoemotional status and lipid metabolism of patients with ischemic heart disease and arrhythmias]. / Vzaimosviaz' osobennostei psikhoémotsional'nogo statusa i lipidnogo obmena u bol'nykh ishemicheskoi bolezn'iu serdtsa s aritmiiami.

Interrelationship of the peculiarities of the psychoemotional status, the activity of lipid peroxidation and the content of blood free fatty acids were studied in 64 CHD patients with arrhythmia. It was shown that prolonged and pronounced psychoemotional strain, high levels of the activity of free radical lipid oxidation and the content of nonesterified fatty acids in the blood of CHD patients promoted the development of cardiac rhythm disturbances, particularly of ventricular extrasystoles. Patients with the psychoemotional strain syndrome demonstrated direct correlation of an induced initial hemiluminiscence flash value and the level of a psychological pattern MMPI by scales 2, 6, 7, 0, as well as close direct correlation of the concentration of free fatty acids with scales 6, 8, F and negative correlation with scale 3. The detection of the psychoemotional strain syndrome in CHD patients, especially in combination with high levels of lipid peroxidation and nonesterified fatty acids in the blood, may evidently serve an important criterion for defining patients at high risk of developing arrhythmias.