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Antibiot Khimioter ; 40(9): 17-9, 1995 Sep.
Article in Russian | MEDLINE | ID: mdl-8651823

ABSTRACT

Bacillus intermedius ribonuclease modified by the residue of adamantane carboxylic acid was prepared. When the cells of chick embryo fibroblasts infected by the fowl plague virus were exposed to the modified ribonuclease, the antiviral activity proved to be higher by comparison to that of the native enzyme. The chemotherapeutic index of the RNAse after the modification increased 4 times.


Subject(s)
Adamantane/analogs & derivatives , Antiviral Agents/isolation & purification , Bacillus/enzymology , Ribonucleases/isolation & purification , Adamantane/chemistry , Animals , Antiviral Agents/pharmacology , Cells, Cultured , Chick Embryo , Fibroblasts/drug effects , Influenza A virus/drug effects , Molecular Structure , Ribonucleases/chemistry , Ribonucleases/pharmacology
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