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1.
Arch Fam Med ; 4(10): 835-42; discussion 843, 1995 Oct.
Article in English | MEDLINE | ID: mdl-7551130

ABSTRACT

OBJECTIVE: To more closely approximate the use of a nonsteroidal inhaled anti-inflammatory medication for asthma, nedocromil sodium, under actual ambulatory practice conditions. DESIGN: Large, open-label trial. PATIENTS: One thousand two hundred one patients from 286 primary care and specialty centers. INTERVENTION: Four weeks of treatment with nedocromil sodium (4 mg delivered from the valve and 3.5 mg delivered from the mouthpiece of a metered inhalor [2 puffs, four times daily]). MAIN OUTCOME MEASURES: Asthma symptom scores, peak expiratory flow rate, a lifestyle assessment measures questionnaire, and mean number of days missed per month from work or school. RESULTS: Statistically significant improvements were seen after 1 and 4 weeks of treatment for cough, daytime and nighttime asthma, morning tightness, peak expiratory flow rate, and all four measured lifestyle assessment factors (P < .001). An additional clinically relevant outcome measure, mean number of days missed per month from work or school, was reduced by 75% (P < .001). No serious adverse reactions were reported. CONCLUSION: This study reproduces the high level of efficacy and safety of nedocromil that was previously reported in placebo-controlled clinical studies.


Subject(s)
Anti-Asthmatic Agents/therapeutic use , Asthma/drug therapy , Nedocromil/therapeutic use , Administration, Inhalation , Adolescent , Adult , Aged , Aged, 80 and over , Ambulatory Care , Anti-Asthmatic Agents/administration & dosage , Anti-Asthmatic Agents/adverse effects , Asthma/physiopathology , Child , Female , Humans , Life Style , Male , Middle Aged , Nedocromil/administration & dosage , Nedocromil/adverse effects , Peak Expiratory Flow Rate , Surveys and Questionnaires , Treatment Outcome
2.
Pa Med ; 96(12): 14-5, 1993 Dec.
Article in English | MEDLINE | ID: mdl-8127594
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