1.
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol
; 20(2): 113-8, 1975.
Article
in Romanian
| MEDLINE
| ID: mdl-128095
ABSTRACT
Direct immunofluorescence supplied evidence of the antiviral action of a new synthetic derivative (5-sulfamido-ITSC) against vaccina virus in HeLa cell cultures. The antiviral potential of the new derivative is expressed by a 10-18 delay in the appearance of the viral antigen and by the quantitative reduction of synthesis. Administered in a single dose of 40 uM/ml, after infection of the HeLa cells, 5-sulfamido-ITSC does not arrest the infection and bring about elimination of the virus from the cell, in the course of a single viral multiplication cycle. Direct immunofluorescence is a rapid, specific method for detection of the in vitro antiviral action of synthetic derivatives.
Subject(s)
Antiviral Agents/pharmacology , Indoles/pharmacology , Isatin/pharmacology , Thiosemicarbazones/pharmacology , Vaccinia virus/drug effects , Fluorescent Antibody Technique , HeLa Cells , Sulfonamides/pharmacology , Virus Replication/drug effects
2.
Stud Cercet Inframicrobiol
; 20(4): 263-73, 1969.
Article
in Romanian
| MEDLINE
| ID: mdl-4190074