ABSTRACT
BACKGROUND: The elderly population in developing countries is likely to increase by 200-280%. Age related diseases like Parkinsonism are also likely to increase in ageing population. The prevalence and awareness of Parkinsonism (and possible PD) amongst them are unknown. METHODS AND MATERIAL: The objective was to know the awareness and occurrence of Parkinsonism (and possible PD) in Old Age Homes in Bangalore, South India. The study design was prospective, direct clinical evaluation, and it was old age homes in Bangalore, South India setting. There were six hundred and twelve residents of the old age homes in Bangalore. A movement disorder neurologist examined 612 elderly residents living in Old age Homes in Bangalore city, India. RESULTS: Parkinsonism was diagnosed in 109 (17.8%) of 612 residents. Possible PD was diagnosed in 9 (1.5% of 612) while in 100 (16.3% of 612) definite PD was diagnosed.94 (86.2%) had bilateral Parkinsonian signs (Stage > or = 2 of Hoehn & Yahr), only 4 (3.7%) of them or the caregivers knew they had PD. CONCLUSIONS: Knowledge about the disease was very low in the elderly residents although the occurrence of Parkinsonism was very high. Improving awareness of PD amongst the elderly and their caregivers might reduce their disability and improve their quality of life.
Subject(s)
Parkinson Disease/diagnosis , Parkinsonian Disorders/diagnosis , Aged , Aged, 80 and over , Female , Homes for the Aged , Humans , India , Male , Middle Aged , Parkinson Disease/drug therapyABSTRACT
BACKGROUND: Clinical data across the globe especially in genetic diseases like Huntington's disease (HD) is most helpful when collected using standardized formats. This helps in proper comparison of clinical and genetic data. METHODS: Herein, we report clinical data on 26 genetically confirmed HD patients from 19 Indian families predominantly from South India. Clinical data and evaluation was performed using standardized formats used by the Huntington Disease Study Group. RESULTS: Adult onset HD was commonest while Juvenile HD (onset <20 years) was observed in approximately 15% of patients. Chorea was the commonest presenting symptom (n=23, 88.5%) while remaining presented with psychiatric symptoms (n=3, 11.5%). Impairment of saccades was observed in approximately 75% of patients. Mean (SD) CAG repeats in the abnormal allele was 48.4 (8.7). Total motor score but not the total behavioral score worsens with duration of symptoms. The functional checklist score correlates with total motor score rather than with duration of symptoms. CONCLUSIONS: We detail clinical characteristics in genetically confirmed HD patients from a predominantly South Indian cohort. We observed a slightly higher occurrence of Juvenile HD. Functional disabilities in our patients correlate with worsening of motor rather than behavioral symptoms.
Subject(s)
Huntington Disease/genetics , Huntington Disease/physiopathology , Adolescent , Adult , Age of Onset , Aged , Anxiety/etiology , Anxiety/physiopathology , Brain/diagnostic imaging , Brain/pathology , Brain/physiopathology , Child , Chorea/etiology , Chorea/physiopathology , Cognition Disorders/etiology , Cognition Disorders/physiopathology , DNA Mutational Analysis , Dysarthria/etiology , Dysarthria/physiopathology , Dystonia/etiology , Dystonia/physiopathology , Family Health , Female , Genetic Testing , Humans , Hypokinesia/etiology , Hypokinesia/physiopathology , India , Irritable Mood/physiology , Male , Middle Aged , Muscle Rigidity/etiology , Muscle Rigidity/physiopathology , Ocular Motility Disorders/etiology , Ocular Motility Disorders/physiopathology , Prospective Studies , Radiography , Trinucleotide Repeat Expansion/geneticsABSTRACT
The authors report on movement disorders that persist for a long duration following Japanese encephalitis (JE). Fifteen patients with diagnosed JE were followed up after an interval of 3 to 5 years. Of the four patients with a movement disorder, two were children with severe generalized dystonia in whom MRI revealed bilateral thalamic lesions. The two adult patients had parkinsonism. MRI in both adult patients showed lesions confined to the substantia nigra. Viral antibody and antigen were absent in the CSF of all patients.
