1.
Comp Biochem Physiol C Comp Pharmacol Toxicol
; 78(2): 475-8, 1984.
Article
in English
| MEDLINE
| ID: mdl-6149099
ABSTRACT
Pigeon erythrocytes were carefully washed in an isotonic neutral buffer, devoid of potassium, and the rate of passive unidirectional efflux of potassium from the cells into a K+-free medium was measured after 20 min, at 40 degrees C. Isoproterenol inhibits K+-efflux by 35-45%, at a cell concentration of 1%; the isoproterenol effect is mediated by beta-adrenergic receptors. Cyclic AMP mimics the effect of isoproterenol, but at 4-5 orders of magnitude higher concentrations. Cyclic AMP increases 20-fold the phosphorylation of purified cell membranes by [gamma 32P]ATP.