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Antimycobacterial flavones from Haplopappus sonorensis.

Murillo, J I; Encarnación-Dimayuga, R; Malmstrøm, J; Christophersen, C; Franzblau, S G.

Fitoterapia ; 74(3): 226-30, 2003 Apr.

Article in English | MEDLINE | ID: mdl-12727485

ABSTRACT

Crude extracts of Haplopappus sonorensis (A. Gray) S.F. Blake (Asteraceae), showed activity against Mycobacterium tuberculosis H(37)Rv. By assay-guided fractionation, 5-hydroxy-3,7,4'-trimethoxyflavone (1). 5,7-dihydroxy-3,4'-dimethoxyflavone (2). and 5,4'-dihydroxy-3,7-dimethoxyflavone (3). were identified as the antimycobacterial principles. Compound 2 was the most active compound.

Subject(s)

Antitubercular Agents/pharmacology , Flavonoids/pharmacology , Haplopappus , Mycobacterium tuberculosis/drug effects , Phytotherapy , Plant Extracts/pharmacology , Humans , Microbial Sensitivity Tests , Tumor Cells, Cultured/drug effects

Neothyoside B, a triterpenoid diglycoside from the Pacific sea cucumber Neothyone gibbosa.

Encarnación, R; Murillo, J I; Nielsen, J; Christophersen, C.

Acta Chem Scand (Cph) ; 50(9): 848-9, 1996 Sep.

Article in English | MEDLINE | ID: mdl-8817870

Subject(s)

Sea Cucumbers/metabolism , Triterpenes/chemistry , Animals , Carbohydrate Sequence , Magnetic Resonance Spectroscopy , Molecular Sequence Data

ABSTRACT

Subject(s)

Subject(s)

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