ABSTRACT
Fibromatosis is the proliferation of connective tissue with local infiltrative growth and a tendency to relapse in contrast with fibrosarcoma which never produces metastases. Two patients, a mother and son diagnosed with fibromatosis of initial cervical location in whom surgical extirpation and complementary radiotherapy were performed. The mother underwent polychemotherapy (adriamicine plus dacarbazine) because of extensive relapse. Definitive resolution was achieved in both cases.
Subject(s)
Fibroma/genetics , Head and Neck Neoplasms/genetics , Muscular Diseases/genetics , Soft Tissue Neoplasms/genetics , Thoracic Neoplasms , Thoracic Neoplasms/genetics , Adolescent , Adult , Combined Modality Therapy , Female , Fibroma/therapy , Head and Neck Neoplasms/therapy , Humans , Male , Muscular Diseases/therapy , Remission Induction , Soft Tissue Neoplasms/therapy , Thoracic Neoplasms/therapyABSTRACT
We study 50 patients with advanced bladder carcinoma, divided into two protocols of 25 patients, treated with polychemotherapy. Protocol I (PAF) formed by DDP at 20 mgrs/m2 day 1 to 5, ADM at 50 mgrs./m2 day 1 and 5-FU at 500 mgrs./m2 day 1, and Protocol II (CISCA) made up of the combination of DDP at 75 mgrs./m2 day 1, ADM at 50 mgrs./2 day 1 and CPM at 600 mgrs./m2 I.V. day 1. In Protocol I the overall response was 60% (RC = 28%, RP = 32%), with amean response duration of 12.24 months, after receiving an average of 4.8 cycles. In Protocol II the results were 60% (RC = 16%, RP = 44%), 7.04 months and 5 cycles per patient, respectively. Both protocols were tolerated well, although Protcol I proved more toxic. Nauseas, vomiting and alopecia were the most common symptoms. There was no significant difference between the survival of responders and non-responders with Protocol I, but there was with Protocol II with (p less than 0.01).
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Transitional Cell/drug therapy , Urinary Bladder Neoplasms/drug therapy , Adult , Aged , Carcinoma, Transitional Cell/pathology , Cisplatin/administration & dosage , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Drug Evaluation , Female , Fluorouracil/administration & dosage , Humans , Male , Middle Aged , Neoplasm Staging , Urinary Bladder Neoplasms/pathologyABSTRACT
The authors tell about one case of peripheral neuropathy of the upper limbs as a complication of cis-diaminedichloroplatinum. It is a rare complication that has to be diagnosed early to prevent invalidating damage.
