Estimating the Memory Order of Electrocorticography Recordings.

OBJECTIVE: This paper presents a data-driven method for estimating the memory order (the average length of the statistical dependence of a given sample on previous samples) of a recorded electrocorticography (ECoG) sequence. METHODS: The proposed inference method is based on the relationship between the loss in predicting the next sample in a time-series and the dependence of this sample on the previous samples. Specifically, the memory order is estimated to be the number of past samples that minimize the least squares error (LSE) in predicting the next sample. To deal with the lack of an analytical model for ECoG recordings, the proposed method combines a collection of different predictors, thereby achieving LSE at least as low as the LSE achieved by each of the different predictors. RESULTS: ECoG recordings from six patients with epilepsy were analyzed, and the empirical cumulative density functions (ECDFs) of the memory orders estimated from these recordings were generated, for rest as well as pre-ictal time intervals. For pre-ictal time intervals, the electrodes corresponding to the seizure-onset-zone were separately analyzed. The estimated ECDFs were different between patients and between different types of blocks. For all the analyzed patients, the estimated memory orders were on the order of tens of milliseconds (up to 100 ms). SIGNIFICANCE: The proposed method facilitates the estimation of the causal associations between ECoG recordings, as these associations strongly depend on the recordings' memory. An improved estimation of causal associations can improve the performance of algorithms that use ECoG recordings to localize the epileptogenic zone. Such algorithms can aid doctors in their pre-surgical planning for the surgery of patients with epilepsy.

SozRank: A new approach for localizing the epileptic seizure onset zone.

Epilepsy is one of the most common neurological disorders affecting about 1% of the world population. For patients with focal seizures that cannot be treated with antiepileptic drugs, the common treatment is a surgical procedure for removal of the seizure onset zone (SOZ). In this work we introduce an algorithm for automatic localization of the seizure onset zone (SOZ) in epileptic patients based on electrocorticography (ECoG) recordings. The proposed algorithm builds upon the hypothesis that the abnormal excessive (or synchronous) neuronal activity in the brain leading to seizures starts in the SOZ and then spreads to other areas in the brain. Thus, when this abnormal activity starts, signals recorded at electrodes close to the SOZ should have a relatively large causal influence on the rest of the recorded signals. The SOZ localization is executed in two steps. First, the algorithm represents the set of electrodes using a directed graph in which nodes correspond to recording electrodes and the edges' weights quantify the pair-wise causal influence between the recorded signals. Then, the algorithm infers the SOZ from the estimated graph using a variant of the PageRank algorithm followed by a novel post-processing phase. Inference results for 19 patients show a close match between the SOZ inferred by the proposed approach and the SOZ estimated by expert neurologists (success rate of 17 out of 19).