1.
Vopr Virusol
; 37(5-6): 235-8, 1992.
Article
in Russian
| MEDLINE
| ID: mdl-1290221
ABSTRACT
The anti-HIV activity of beta-glycyrrhizic acid (GA) and various derivatives was studied using various strains of HIV-1 and HIV-2 in primary infected lymphoblastoid cells MT-4 and monocyte cell line U-973 chronically infected with HIV-1 and containing provirus (GKV 4005). Beta-glycyrrhizic acid and its derivatives were shown to effectively inhibit HIV-1 reproduction in MT-4 cells. The antiviral effect of beta-GA sodium salt exceeded that of AZT in cells GKV 4005. The selective indices for some GA salts were evaluated, namely: 53 for 1NH4 salt of GA, 6.7 for 1K-2Li salt of GA; 4.45 for GA. The mechanism of GA action is discussed.
Subject(s)
Antiviral Agents/pharmacology , Glycyrrhetinic Acid/analogs & derivatives , Glycyrrhetinic Acid/pharmacology , HIV-1/drug effects , HIV-2/drug effects , Aurintricarboxylic Acid/pharmacology , Depression, Chemical , Glycyrrhizic Acid , HIV-1/enzymology , HIV-1/physiology , HIV-2/enzymology , HIV-2/physiology , Humans , Solutions , Time Factors , Viral Proteins/analysis , Viral Proteins/drug effects , Virus Cultivation , Virus Replication/drug effects , Zidovudine/pharmacology
2.
Farmakol Toksikol
; 54(5): 47-50, 1991.
Article
in Russian
| MEDLINE
| ID: mdl-1800149