1.
Pediatr Blood Cancer
; 48(2): 238-40, 2007 Feb.
Article
in English
| MEDLINE
| ID: mdl-16206187
ABSTRACT
A 6-year-old boy with skin lesions suggestive of neurofibromatosis developed a frontotemporal primitive neuroectodermal tumor and was subsequently treated with surgery, craniospinal irradiation, and chemotherapy. After the sixth cycle of treatment with vincristine sulfate, 9 months after diagnosis, the child developed a rapidly progressive bilateral deterioration in visual acuity. Retinal appearances were consistent with optic neuropathy. Gene studies for neurocutaneous syndromes were negative. Brain imaging at this time showed no tumor progression, and in the absence of other etiologies, we implicate vincristine as a probable cause. Discontinuation of this particular agent has allowed bilateral improvement in visual acuity.
Subject(s)
Optic Nerve Diseases/chemically induced , Vincristine/adverse effects , Child , Humans , Male , Neuroectodermal Tumors, Primitive, Peripheral/therapy
2.
N Engl J Med
; 352(22): 2353-5; author reply 2353-5, 2005 Jun 02.
Article
in English
| MEDLINE
| ID: mdl-15930430