Subject(s)
Diflunisal/adverse effects , Drug Hypersensitivity/physiopathology , Salicylates/adverse effects , Aged , Anemia, Hemolytic/chemically induced , Anemia, Hemolytic/drug therapy , Dermatitis, Exfoliative/chemically induced , Dermatitis, Exfoliative/drug therapy , Drug Hypersensitivity/drug therapy , Female , Humans , Liver Function Tests , Middle Aged , Prednisone/therapeutic useABSTRACT
Lichen sclerosus et atrophicus (LS&A) of the vulva and perianal skin is an atrophic condition that con occur alone or in association with additional lesions situated elsewhere on the skin surface. The cases of three sisters with LS&A of the vulva are reported herein; in one a squamous cell carcinoma developed in a hyperplastic area of mixed dystrophy (LS&A with foci of hyperplasia). Familial occurrences of LS&A are rare. Malignant neoplasms arising in areas of LS&A have been reported previously. Squamous cell carcinoma arises in hyperplastic areas of mixed dystrophy where there is evidence of both LS&A and epithelial hyperplasia.
Subject(s)
Skin Diseases/genetics , Vulvar Lichen Sclerosus/genetics , Aged , Anal Canal , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/pathology , Female , Humans , Skin Diseases/complications , Skin Diseases/pathology , Vulvar Lichen Sclerosus/complications , Vulvar Lichen Sclerosus/pathology , Vulvar Neoplasms/complications , Vulvar Neoplasms/pathologyABSTRACT
In a patient with a long history of classical psoriasis, a widespread pustular eruption suddenly developed. The precipitating factor appeared to be a high-dose, progesterone-containing hormone preparation. The clinical appearance and manifestations in this patient were typical of pustular psoriasis.
