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Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.
Murray, Marta K; Teran, Victor A; Chapleau, Jean-Philippe; Wang, Baomin; Kim, Su Hyon; LaBranche, Celia C; Richard, Jonathan; Montefiori, David C; Finzi, Andrés; Yuan, Wen.
J Virol ; 89(20): 10707-11, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26246571

ABSTRACT

CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4. The envelope (Env) glycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (CD4i) epitopes. Reports have demonstrated that CD4i antibodies mediate antibody-dependent cellular cytotoxicity (ADCC). Here we investigated the immunogenicity of soluble Env trimers (sgp140) from a CD4-independent HIV-1 in guinea pigs and found that the sgp140 elicited ADCC-mediating antibodies. Therefore, these sgp140 might be useful in vaccine regimens aimed at eliciting ADCC responses.


Subject(s)
Antibody-Dependent Cell Cytotoxicity/genetics , HIV Antibodies/biosynthesis , HIV Infections/prevention & control , HIV-1/immunology , env Gene Products, Human Immunodeficiency Virus/immunology , Animals , Binding Sites , CD4 Antigens/genetics , CD4 Antigens/immunology , Epitopes/chemistry , Epitopes/genetics , Epitopes/immunology , Gene Expression , Guinea Pigs , HIV Infections/immunology , HIV Infections/virology , HIV-1/genetics , Humans , Immunization , Protein Binding , Protein Multimerization , Solubility , env Gene Products, Human Immunodeficiency Virus/administration & dosage , env Gene Products, Human Immunodeficiency Virus/chemistry , env Gene Products, Human Immunodeficiency Virus/genetics
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