Percutaneous treatment of non-functioning arteriovenous fistulas.

AIM: To show our results in the percutaneous treatment of non-functioning arteriovenous fistulas of patients undergoing haemodialysis and to discuss the results of the literature. METHODS: Thirty-four patients with 37 non-functioning arteriovenous fistulas (29 native, 8 grafts) underwent percutaneous angioplasty. Restoration of vessel lumen and function at the following dialysis were considered as successful outcome. Primary and secondary patency rates at 12 months were calculated by means of Kaplan-Meier analysis. RESULTS: Fifty-six interventions were performed, 42 on native fistulas and 14 on grafts. Immediate technical and clinical success were obtained in 98% of procedures. For native fistulas, primary and secondary patency rates at 12 months were 41% and 62%, respectively. For grafts, 14% and 34%, respectively. Only one complication was observed. CONCLUSION: Minimally invasive percutaneous treatment allows to restore function of most arterio-venous fistulas with good long term patency.

Assessment of patients with acute mesenteric ischemia: multislice computed tomography signs and clinical performance in a group of patients with surgical correlation.

AIM: The aim of this paper was to describe signs and performance of multislice computed tomography (MSCT) in patients with acute mesenteric infarction (AMI). METHODS: MSCT examinations of 26 patients with AMI and of 34 patients with acute abdomen and surgical diagnosis excluding AMI were retrospectively analyzed. All studies were performed with arterial and portal venous phase scans, 2.5 mm thickness, 1.25 mm image interval. All abnormal findings at MSCT in patients with AMI were recor- ded. Patients with MSCT evidence of mesenteric artery occlusion or pneumatosis or venous gas or, alternatively, bowel thicken-ing associated with lack of wall enhancement or venous thrombosis or parenchimal infarction were considered to be affected by AMI. RESULTS: AMI was due to mesenteric artery thrombosis in 17 patients, mesenteric vein thrombosis in 7, and nonocclusive ischemia in 2. In 16/17 patients arterial thrombosis was visualized, in 7/7 venous thrombosis was found. Portal or mesenteric vein gas was seen in 5% and pneumatosis in 38%; bowel wall thickening associated with other signs was found in 31%. Sensitivity and specificity were 92% and 100%, respectively. CONCLUSIONS: MSCT allows an accurate assessment of the mesenteric circulation and the bowel wall. This makes possible optimal visualization of signs of AMI resulting in a good clinical performance.

Tubular carcinoma of the breast: pathological, clinical, and ultrasonographic findings. A review of the literature.

PURPOSE: Tubular carcinoma of the breast is a well-differentiated adenocarcinoma. The aim of this paper is to analyse its clinical and imaging findings and to review the radiological literature. MATERIALS AND METHODS: A retrospective review of 560 consecutive histologically proven carcinomas of the breast was made. RESULTS: Sixteen pure (tubular component >90%) tubular carcinomas were found in 14 women (mean age 55 years). Three lesions were palpable. At mammography, five were not detected, three presented as spiculated masses, two as masses with irregular margins, two as spiculated masses with microcalcifications, two as distortions, one as a cluster of microcalcifications and one as asymmetric density. At ultrasonography, two lesions were not detected; the remaining presenting as hypoechoic nodules with irregular (13) or well-defined (one) contours. Fine-needle aspiration cytology diagnosed 11 carcinomas and two "atypical cells". In three, core biopsy was made: in the first, a complex sclerosing lesion with atypical cells was suggested, in the second differential diagnosis between tubular carcinoma and sclerosing adenosis was proposed and in the third a tubular carcinoma. The mean diameter of the lesions at histopathology was 9.7+/-4.9 mm. Metastatic nodes were found in one patient only. CONCLUSIONS: Tubular carcinoma presents as a small, nonpalpable lesion, with nonspecific imaging patterns. Nodal metastases are rare.

MR versus multislice CT cholangiography in evaluating patients with obstruction of the biliary tract.

BACKGROUND: We compared magnetic resonance cholangiography (MRC) with multislice computed tomographic (MSCT) cholangiography in the assessment of patients with bile duct obstruction. METHODS: Thirty-six patients with clinical or biochemical signs of biliary obstruction were prospectively studied. MRC was performed with fast spin-echo and single-shot fast spin-echo sequences. Source images, maximum intensity projection, and multiplanar reconstruction were evaluated. MSCT cholangiography was performed without biliary contrast agent, with intravenous injection of 150 mL of iodinated contrast material at 4 mL/s, 2.5-mm slice thickness, 7.5-mm/s table speed, and 1.25-mm reconstruction interval. Axial, multiplanar, and minimum intensity projection reformatted images were evaluated. MRC and MSCT findings were compared with endoscopic retrograde cholangiopancreatography (ERCP; 20 patients), percutaneous cholangiography (eight patients), intraoperative cholangiography (two patients), surgery (11 patients), and cytology (11 patients) with respect to cause and site of obstruction. RESULTS: With regard to presence and site of obstruction, agreement was observed across MRC, MSCT cholangiography, and reference investigations in all cases. Concerning cause, the correct diagnosis was made by MSCT cholangiography in 34 of 36 patients. Two cases of common bile duct lithiasis, diagnosed on MRC and ERCP, were missed by MSCT cholangiography. CONCLUSION: MSCT cholangiography can be considered a possible noninvasive alternative to MRC.

Partial unilateral intracavernosal hematoma in a long-distance mountain biker: a case report.

We present a case of spontaneous partial unilateral hematoma of the bulb of the corpus cavernosum in a long-mileage mountain biker. Ultrasonography, magnetic resonance imaging, and histopathological findings are described.

Value of an early arteriographic acquisition for evaluating the splanchnic vessels as an adjunct to biphasic CT using a multislice scanner.

Our objective was to assess the clinical value of an early arterial scan for assessing the hepatic and mesenteric vasculature in patients with suspected primary or metastatic hypervascular liver disease undergoing multislice computed tomography. In 42 patients a very early arteriographic scan was performed before standard arterial and portal venous scans. Technical parameters of the very early acquisition were: 2.5-mm image thickness; table speed 15 mm/s; pitch 6; 120 kVp; 300 mA; 8.9-s scan time; cranio-caudal acquisition direction; 1.25-mm image interval reconstruction;16-s delay after injection of 110 ml of iodinated contrast agent at 5 ml/s; scan volume focused to image hepatic, splenic, and superior mesenteric arteries (SMA). Standard arterial and portal venous phases were performed with 5-mm image thickness, 15-mm/s table speed, pitch 6, 8- to 10-s scan time, 30- and 70-s delay. The three phases were performed during three different breath-holds. Axial, multiplanar reformatted, maximum intensity projection, and volume-rendering images were evaluated. Image quality was scored, and vascular abnormalities were recorded. Digital subtraction angiography (DSA) was performed in 17 patients. In 36 of 42 patients good-quality CT angiograms were obtained. In 9 patients 12 vascular abnormalities were found, all confirmed at DSA: 3 right hepatic arteries originating from the SMA, 2 left hepatic arteries from the gastric artery, 2 stenoses of the SMA, 1 independent origin of the hepatic and splenic arteries, 2 arteriovenous fistulas, and 2 aneurysms of the common hepatic artery and the SMA. This technique could add important information about vascular splanchnic anatomy which would be particularly useful for surgeons and interventional radiologists.

Pictorial essay: magnetic resonance imaging of adrenal masses.

In many cases, adrenal lesions are incidentally discovered during ultrasonography or computed tomography in the staging or follow-up of patients with primary malignancies. The most important issue in the radiological management of adrenal masses is the differential diagnosis between benign and malignant lesions. Magnetic resonance (MR) plays an important role in the characterization of such lesions. Our aim was to present the MR techniques and to review the MR features of most common adrenal masses.

Multislice CT cholangiography without biliary contrast agent: technique and initial clinical results in the assessment of patients with biliary obstruction.

Our objective was to describe our technique for multislice CT cholangiography without cholangiographic contrast agent, and to present our preliminary clinical results. Thirty-seven patients with suspected biliary obstruction were studied. A multislice CT unit was used with the following technical parameters: 2.5-mm collimation; 7.5-mm/s table speed; pitch 6; 0.8-s rotation time; 300 mA; 120 kVp; 18- to 24-s scan time; scan volume ranging from the hepatic dome to below the pancreatic head; 70-s delay after injection of 150 ml of iodinated contrast agent at 4 ml/s. No biliary contrast material was given; oral iodinated contrast agent was administered to opacify bowel loops. Axial, multiplanar reformatted, and minimum intensity projection images were evaluated. The CT findings were compared with the gold standard techniques: endoscopic retrograde cholangiography (ERCP) in 30 patients, percutaneous transhepatic cholangiography in 5, and intraoperative cholangiography in 2. In 5 patients with ampullary lesions biopsy was made during ERCP, 9 underwent surgery, and 11 US-guided fine-needle aspiration. Bile ducts appeared hypodense within the surrounding enhanced structures. Regarding the site of obstruction, agreement between multislice CT and conventional cholangiography was observed in all cases. One patient presented negative findings on both CT and ERCP. In 31 of 36 (86%) patients, multislice CT cholangiography without cholangiographic contrast agent correctly assessed the cause of bile duct obstruction. Multislice CT cholangiography without cholangiographic contrast agent seems to be a promising diagnostic tool in the assessment of patients with bile duct obstruction.

Detection of changes in diastolic function by pulmonary venous flow analysis in women athletes.

BACKGROUND: Left ventricular cavity dimension, wall thickness, relaxation, and filling increase with exercise training and have a role in enhancing physical performance. We probed whether changes in diastole may develop separately from those in cardiac morphometry and still contribute to improve physical performance. Challenging diastole by preload reduction with standing and integrating mitral flow analysis with the pulmonary venous flow analysis were viewed as a means for detecting fine diastolic variations. METHODS: Patterns of mitral, tricuspid, and pulmonary venous flow were evaluated by echo Doppler imaging in the supine and standing positions in 11 long-distance runner women athletes participating in training programs and having no or very mild cardiac morphologic alterations and were compared with those in 11 healthy women active in daily life not participating in training programs. Maximal exercise tolerance was tested in both groups with a treadmill with use of the standard Bruce protocol. RESULTS: Echocardiographic left ventricular mass index and mitral and pulmonary flow patterns in athletes and controls were similar while they were supine. Major (P<.01) percent variations and differences between athletes and controls with standing were smaller decrease in right (-12% +/- 5% vs -29% +/- 5%) and left ventricular (-3% +/- 1% vs -9% +/- 2%) dimensions and stroke volume (-7% +/- 4% vs -23% +/- 4%), smaller lengthening of early mitral deceleration (+7% +/- 4% vs +18% +/- 5%), and isovolumic relaxation (-3% +/- 5% vs +15% +/- 7%) times. Athletes showed greater reduction in pulmonary S wave peak velocity (-25% +/- 10% vs -12.5% +/- 7%) and time velocity integral (Si) (-50% +/- 9% vs -21% +/- 8%), greater increases in pulmonary venous diastolic (D) wave peak velocity(+20% +/- 9% vs +12% +/- 10%, meters per second), and time velocity integral (Di) (+81% +/- 16% vs +27% +/- 14%) and greater decrease of S/D(-30% +/- 6% vs -18% +/- 5%) and Si/Di (-70% +/- 10% vs -33% +/- 5%) ratios. At multivariate analysis standing Si/Di was the strongest independent predictor of better exercise tolerance (peak exercise time 1035 +/- 88 sec in athletes, 751 +/- 20 in controls). CONCLUSIONS: Pulmonary flow analysis in athletes while standing can detect changes in diastolic function that are dissociated from apparent left ventricular morphologic alterations, are undetected in the supine position, and may, in part, determine exercise performance.

Brief periods of occlusion and reperfusion increase skeletal muscle force output in humans.

Prolonged periods of ischemia/reperfusion are known to deleteriously affect skeletal muscle performance. However, in animal models, brief bouts of both skeletal and cardiac muscle ischemia/reperfusion have been shown to decrease skeletal muscle injury and increase skeletal muscle force output, a phenomenon termed "preconditioning". Because there are transient periods of ischemia/reperfusion during isometric and concentric muscle contractions, the purpose of this study was to examine how short duration forearm occlusion/reperfusion prior to exercise, influenced isometric skeletal muscle force output in humans. Eleven subjects (6 men and 5 women, mean age 25 +/- 1 years) participated in this study. Using a Biodex multijoint ergometer, a protocol of isolated, isometric forearm wrist flexions was utilized to measure muscle force output in two separate trials. In the first trial, 15 isometric maximal voluntary contractions (MVCs) of the wrist flexors were performed in 20 intervals interspersed with 10 s of rest. In the second trial, forearm occlusion was induced (2 min at 200 mmHg by blood pressure cuff occlusion, with 10 s of hyperemia) prior to exercise. Following cuff occlusion, an identical exercise protocol was followed, i.e. 15 isometric wrist flexor MVCs performed in 20 intervals interspersed with 10 s of rest. The total force output over 15 MVCs was greater following intermittent cuff occlusion (no occlusion 2619 +/- 320 ft.lbs vs cuff occlusion 2986 +/- 195 ft.lbs; p < 0.05). The mean force output per MVC also increased during exercise following intermittent cuff occlusion (no occlusion 174 +/- 21 ft.lbs vs cuff occlusion 199 +/- 13 ft.lbs; p < 0.05). In a second set of experiments, we found a 3 to 4 fold hyperemic blood flow following cuff occlusion. These data suggest that brief periods of cuff occlusion/reperfusion may increase repetitive MVC force output by skeletal muscle. Although further study is needed to fully understand the effects of occlusion/reperfusion on skeletal muscle force output, we hypothesize that, in part, this putative effects is secondary to the hyperemic blood flow which follows cuff occlusion.

[The computed tomographic diagnosis of malignant pleural mesothelioma. A multicenter study]. / Diagnosi con Tomografia Computerizzata del mesotelioma pleurico maligno. Studio multicentrico.

CT features are described and accuracy of the method is discussed in the diagnosis of malignant pleural mesothelioma. Ninety-eight patients suffering from pleural disease mimicking mesothelioma were examined by means of III-generation CT scanners; according to the final diagnosis, 37 patients suffered from malignant pleural mesothelioma, 27 from other malignant pleural diseases and 34 from various benign diseases. In all patients a series of CT signs was evaluated: pleural thickening patterns, lesion spread and possible associated characters. In the diagnosis of mesothelioma CT showed 72.5% sensitivity, 63.8% specificity, 68.3% diagnostic accuracy, 68.5% positive predictive value and 68.2% negative predictive value. Some significant CT patterns in distinguishing malignant from benign pleural disease were identified, while the characterization of malignant disease (mesothelioma versus other neoplastic conditions) proved to be unreliable.

Carotid body tumors: US evaluation.

The ultrasound (US) findings in 20 patients with 23 carotid-body chemodectomas were reviewed. Twenty-two of 23 tumors could be seen at US; the remaining lesion could not be differentiated from surrounding enlarged lymph nodes resulting from thyroid cancer. The lesions were solid, slightly heterogeneous masses that ranged in size from 1.2 to 5.0 cm and were located within the carotid bifurcation. Pulsed Doppler analysis of blood flow within the tumor mass was possible in eight patients with nine chemodectomas, and low-resistance waveforms were obtained from multiple sites within the mass in all cases. The diagnostic possibility of a chemodectoma has to be considered when a solid mass is detected within the carotid bifurcation. On the basis of these findings, as US diagnosis was possible in 18 of 20 patients in the authors' series. Doppler analysis of the mass to evaluate intratumor blood flow is helpful in differentiating chemodectomas from other solid, nonhypervascular masses.

Chest wall involvement by lung cancer: computed tomographic detection and results of operation.

The aim of this prospective study was to evaluate: (1) the role of computed tomographic scanning in predicting chest wall invasion by peripheral lung cancer and (2) the results of operation according to the depth of chest wall involvement and other potential indicators of long-term survival. One hundred twelve patients with non-small cell lung cancer adjacent to the pleural surface who underwent computed tomographic scanning and subsequent thoracotomy were entered into this study. Tumor invasion was confined to the visceral pleura in 53 patients, to the parietal pleura in 18 patients, and to intercostal muscles in 25 patients; invasion extended beyond this layer in 16 patients. The computed tomographic criteria for chest wall invasion were (1) obliteration of the extrapleural fat plane, (2) the length of the tumor-pleura contact, (3) the ratio between the tumor-pleura contact and the tumor diameter, (4) the angle of the tumor with the pleura, (5) a mass involving the chest wall, and (6) rib destruction. The computed tomographic criteria 1 and 3 were significantly related to pathologic findings. Sensitivity was 85% for criterion 1 and 83% for criterion 3, specificity being 87% and 80%, respectively. Long-term survival of patients with T3 disease critically depended on the lymph node state and completeness of resection. The adenocarcinoma cell type and the T4 category were unfavorable prognostic factors. The depth of chest wall invasion did not affect survival, except for extensive rib and soft tissue infiltration. En bloc resection yielded better results than discontinuous resection.

MR imaging of adrenal myelolipomas.

The magnetic resonance (MR) images in six patients with seven adrenal myelolipomas are presented. Four lesions involved the right gland, and three the left; they ranged from 3 to 12.5 cm in diameter. Magnetic resonance was able to image all lesions. Using T1-weighted sequences, three structural patterns were observed; (a) homogeneous masses with intensity equal to adjacent fat (three cases); (b) heterogeneous masses with fat intensity areas and areas similar to renal cortex (two cases); and (c) nodules quite different from fat, hypointense to the liver (two cases). On T2-weighted images, myelolipomas were slightly hypointense to fat and either hypo- or isointense to the liver. A comparison with the results of CT studies was possible in all cases, and good correlation with determination of the presence and quantity of fat density tissues within the lesions was observed. However, MR imaging did not seem to help in diagnosing adrenal myelolipoma in patients with equivocal CT findings, and needle biopsy is still needed in difficult cases.

[Type III entrapment syndrome of the popliteal artery. Presentation of a clinical case with diagnostic and therapeutic discussion]. / Sindrome da "entrapment" della poplitea tipo III. Presentazione di un caso clinico con discussione diagnostica e terapeutica.

Following a short review of the various types of possible abnormalities in the popliteal artery entrapment syndrome, a case is presented which was misdiagnosed for more than 2 years. Problems concerning the differential diagnosis are discussed together with details of the surgical approach performed using the medial incision and the PTFE prosthesis.

Myelolipoma of the adrenal gland: sonographic and CT features.

The radiologic findings in 13 patients with pathologically proved adrenal myelolipomas were reviewed. All lesions involved the right adrenal gland; they ranged from 2 to 9 cm in diameter. Sonograms showed hyperechoic tumors in 11 cases (five homogeneous, six heterogeneous). Two myelolipomas composed primarily of myeloid tissue were hypoechoic. A propagation speed artifact was seen in seven lesions, all of which were composed primarily of fat and larger than 4 cm. CT identified fat-density tissues in all lesions. Contrast-enhanced CT showed positive attenuation values in the two predominantly myeloid tumors. CT appears to be sensitive for the diagnosis of adrenal myelolipomas. However, precontrast images are required to avoid errors.

[Echography in the study of thoracic pathology. II-- Guided biopsy]. / L'ecografia nello studio della patologia toracica. Nota II--Guida alla biopsia.

The usefulness of ultrasonic studies for guiding the needle during biopsy of solid lesions or evacuation of saccate effusions and empyemas. Is a explained possible diagnostic protocol is then proposed which includes the ultrasonic examination in the diagnostic approach to parietal, mediastinic or diaphragmatic lesions.

[Echography in the study of thoracic pathology. I--Indications and limitations]. / L'ecografia nello studio della patologia toracica. Nota I--Indicazioni e limiti.

The role of echography in the study of the thorax is evaluated: after reporting the technical limits due to the peculiar anatomy of this region, personal experience is presented. This method extremely precise to define the solid or liquid nature of tightly adherent to the chest wall lesions, but it is non specific to assess their benign or malignant behaviour. Ultrasounds have their on limits in drawing the extension of such lesions; these limits have been overcome by CT and MR. Finally the usefulness of the method in studying the diaphragm and its pathology is briefly described.

[Computerized tomography in Peyronie's disease. Clinico-radiological comparison]. / La TC nella malattia di La Peyronie. Confronto clinico-radiologico.

The diagnostic capabilities of Computed Tomography (CT) in the study of Peyronie's disease are assessed. Twenty-four patients, with different symptoms and a variety of findings on physical examination (from normal to large painful plaques), were studied with third-generation CT equipment. CT defined the normal pattern of the albuginea, as a hyperdense (ranging from 80 to 100 HU) thin and regular line on the periphery of the corpora cavernosa. Pathologic features such as irregularities, disruptions and calcifications of the tunica can be identified; irregularities are shown as circumscribed zones of hyper or hypodensity, disruptions as small or large areas of complete absence of the thin regular line of albuginea. Calcifications are identified as hyperdense nodular or plaquelike areas of 200-300 HU. When physical examination and CT patterns are compared, the reliability of the method is revealed. It provides an accurate definition of the albugineal lesions, imaging all abnormalities detected on physical examination and demonstrating additional, non-palpable and doubtful lesions. Physical examination and CT findings concurred in 19 cases (79%), whereas disagreement was observed in 5 (12%). In 3 cases CT showed calcified plaques not revealed on physical examination; in 2 cases the plaques revealed by palpation were not confirmed by CT. Furthermore there may be a connection between CT aspects of the albuginea and the hystological findings in the disease: irregularities could represent the early stage, interruptions the mid-stage and calcifications irreversible final abnormalities. CT, being a non-traumatic, harmless diagnostic method, improves the clinical evaluation of the patient and can facilitate the choice of the most suitable therapeutic modalities, as well as the follow-up of their results.

The sonographic appearance of duodenal lesions.

The sonographic findings in 17 patients with duodenal tumors and in one patient with a benign ulcer and stricture of the duodenum were reviewed. An abdominal mass was detected sonographically in all patients; in 15 of 18 cases, such lesions presented high-level central echoes and hypoechoic periphery. Identification of the duodenal origin of the disease was possible by sonography in only 16 of 18 patients: by evaluation of the relationship of the mass with abdominal vessels in eight patients; by demonstrating that the lesion was continuous with a normal duodenum in seven patients; or by demonstrating the mass within the duodenum itself in one patient. Signs and symptoms of duodenal tumors are usually nonspecific, and sonography can be used as the first imaging method in these cases. A careful analysis of the relationship of the tumor to surrounding structures may allow correct identification of its origin.