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1.
Int J Tuberc Lung Dis ; 17(1): 76-8, 2013 Jan.
Article in English | MEDLINE | ID: mdl-23114284

ABSTRACT

We describe 11 cases of anti-tuberculosis DRESS (drug-related rash with eosinophilia and systemic symptoms) syndrome, a potentially serious complication of treatment that led to interruption of treatment for prolonged periods, systemic corticosteroid use and the resumption of treatment with less effective regimens. All patients had rash and toxic hepatitis, one died of multi-organ failure and, contrary to expectations, the evolution of tuberculosis (advanced in most cases) did not progress under corticosteroid treatment. The drug most frequently involved was rifampicin, while retreatment schemes included, in most cases, levofloxacin, ethambutol, streptomycin and cycloserine.


Subject(s)
Antitubercular Agents/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Drug Eruptions/etiology , Eosinophilia/chemically induced , Exanthema/chemically induced , Adolescent , Adult , Chemical and Drug Induced Liver Injury/therapy , Drug Eruptions/therapy , Eosinophilia/therapy , Exanthema/therapy , Female , Humans , Male , Retrospective Studies , Syndrome , Young Adult
2.
Medicina (B Aires) ; 50(1): 3-8, 1990.
Article in Spanish | MEDLINE | ID: mdl-2292908

ABSTRACT

In order to detect an association between HIV infection and tuberculosis (TB), 130 TB inpatients were studied one of whom presented a pulmonary disease due to Mycobacterium avium intracellulare. All had advanced TB, 95.4%, with pulmonary localization. Serum anti-HIV antibodies were detected by ELISA and their presence confirmed by immunoblotting in 4 (3.1%) individuals, three males and one female, with different degrees of pulmonary TB. Of the males, 1 was bisexual, 2 were promiscuous, and the female was the sexual partner of a non symptomatic HIV-infected man. No immunological disturbances or other AIDS related alterations were observed. There was one case of miliary TB, but neither atypical X-ray abnormalities nor extrapulmonary involvement were found. Tuberculin reaction was positive in three of the four HIV infected patients. Clinical, radiological and bacteriological evolution were favorable. Adverse drug reaction occurred in two cases, one of them presenting serious toxidermia caused by isoniazid. Of the 130 individuals, 12 presented risk factors for HIV infection so that the prevalence of anti-HIV antibodies presented here, 4 cases out of 12, is consistent with data from previous reports for high risk populations.


Subject(s)
Acquired Immunodeficiency Syndrome/complications , Tuberculosis/complications , AIDS Serodiagnosis , Acquired Immunodeficiency Syndrome/diagnosis , Acquired Immunodeficiency Syndrome/immunology , Adolescent , Adult , Aged , Female , HIV Antibodies/analysis , Humans , Male , Middle Aged , Risk Factors , Tuberculosis/diagnosis , Tuberculosis, Pulmonary/complications
3.
Medicina [B Aires] ; 50(1): 3-8, 1990.
Article in Spanish | BINACIS | ID: bin-51708

ABSTRACT

In order to detect an association between HIV infection and tuberculosis (TB), 130 TB inpatients were studied one of whom presented a pulmonary disease due to Mycobacterium avium intracellulare. All had advanced TB, 95.4


, with pulmonary localization. Serum anti-HIV antibodies were detected by ELISA and their presence confirmed by immunoblotting in 4 (3.1


) individuals, three males and one female, with different degrees of pulmonary TB. Of the males, 1 was bisexual, 2 were promiscuous, and the female was the sexual partner of a non symptomatic HIV-infected man. No immunological disturbances or other AIDS related alterations were observed. There was one case of miliary TB, but neither atypical X-ray abnormalities nor extrapulmonary involvement were found. Tuberculin reaction was positive in three of the four HIV infected patients. Clinical, radiological and bacteriological evolution were favorable. Adverse drug reaction occurred in two cases, one of them presenting serious toxidermia caused by isoniazid. Of the 130 individuals, 12 presented risk factors for HIV infection so that the prevalence of anti-HIV antibodies presented here, 4 cases out of 12, is consistent with data from previous reports for high risk populations.

4.
Medicina [B.Aires] ; 50(1): 3-8, 1990. Tab
Article in Spanish | BINACIS | ID: bin-28094

ABSTRACT

Se estudiaron 129 enfermos con tuberculosis grave y 1 con micobacteriosis debida a M. avium intracellulare internados en el Pabellón Koch del Hospital Francisco J. Miñiz durante el primer bimestre de 1988. Se hallaron anticuerpos contra HIV en 4 pacientes (3,1%), 3 hombres y una mujer. Todos ellos tenían algun factor de riesgo para infección con HIV: de los hombres, uno era bisexual y los otros dos declararon ser promiscuos; la mujer era pareja sexual de un individuo HIV positivo. En ninguno se detectaron trastornos inmunológicos, ni otras alteraciones atribuibles a la infección con HIV. Los 4 pacientes presentaron formas de tuberculosis pulmonar graves y en un caso diseminación miliar. No se hallaron formas atípiicas ni extrapulmonares. La prueba tuberculínica fue positiva en 3 de los 4 pacientes. La respuesta clínica, radiológica y bacteriológica fue favorable. Se produjeron reacciones adversas medicamentosas en dos pacientes, debiéndose suspender la administración de isoniacida en uno de ellos, debido a una toxidermia grave. La presentación y evolución de la tuberculosis fue similar en todos no habiéndose encontrado ninguna variable que permitera discriminar entre los HIV positivos o negativos. Enfatizamos la necesidad de realizar un estudio epidemiológico similar de mayor envergadura para detectar la tendencia ascendente que problablemente tendrá la asociación entre tuberculosis e infección con HIV (AU)


Subject(s)
Adolescent , Adult , Middle Aged , Aged , Humans , Male , Female , Acquired Immunodeficiency Syndrome/complications , Tuberculosis/complications , HIV Antibodies/analysis , Acquired Immunodeficiency Syndrome/immunology , Acquired Immunodeficiency Syndrome/diagnosis , Tuberculosis/diagnosis , Tuberculosis, Pulmonary/complications , Risk Factors , AIDS Serodiagnosis
5.
Medicina (B.Aires) ; 50(1): 3-8, 1990. tab
Article in Spanish | LILACS | ID: lil-86753

ABSTRACT

Se estudiaron 129 enfermos con tuberculosis grave y 1 con micobacteriosis debida a M. avium intracellulare internados en el Pabellón Koch del Hospital Francisco J. Miñiz durante el primer bimestre de 1988. Se hallaron anticuerpos contra HIV en 4 pacientes (3,1%), 3 hombres y una mujer. Todos ellos tenían algun factor de riesgo para infección con HIV: de los hombres, uno era bisexual y los otros dos declararon ser promiscuos; la mujer era pareja sexual de un individuo HIV positivo. En ninguno se detectaron trastornos inmunológicos, ni otras alteraciones atribuibles a la infección con HIV. Los 4 pacientes presentaron formas de tuberculosis pulmonar graves y en un caso diseminación miliar. No se hallaron formas atípiicas ni extrapulmonares. La prueba tuberculínica fue positiva en 3 de los 4 pacientes. La respuesta clínica, radiológica y bacteriológica fue favorable. Se produjeron reacciones adversas medicamentosas en dos pacientes, debiéndose suspender la administración de isoniacida en uno de ellos, debido a una toxidermia grave. La presentación y evolución de la tuberculosis fue similar en todos no habiéndose encontrado ninguna variable que permitera discriminar entre los HIV positivos o negativos. Enfatizamos la necesidad de realizar un estudio epidemiológico similar de mayor envergadura para detectar la tendencia ascendente que problablemente tendrá la asociación entre tuberculosis e infección con HIV


Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Acquired Immunodeficiency Syndrome/complications , Tuberculosis/complications , Acquired Immunodeficiency Syndrome/diagnosis , Acquired Immunodeficiency Syndrome/immunology , AIDS Serodiagnosis , HIV Antibodies/analysis , Risk Factors , Tuberculosis, Pulmonary/complications , Tuberculosis/diagnosis
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