Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Biochemistry (Mosc) ; 83(6): 690-700, 2018 Jun.
Article in English | MEDLINE | ID: mdl-30195325

ABSTRACT

Cell nucleus is characterized by strong compartmentalization of structural components in its three-dimensional space. Certain genomic functions are accompanied by changes in the localization of chromatin loci and nuclear bodies. Here we review recent data on the mobility of nuclear components and the role of this mobility in genome functioning.


Subject(s)
Cell Nucleus/metabolism , Genome , Animals , Cell Nucleus/genetics , Chromatin/genetics , Chromatin/metabolism , DNA Damage , Humans , Nucleosomes/metabolism
2.
Biochemistry (Mosc) ; 81(9): 941-50, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27682166

ABSTRACT

Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.


Subject(s)
Chromosomal Proteins, Non-Histone , Evolution, Molecular , tRNA Methyltransferases , Animals , Chromosomal Proteins, Non-Histone/chemistry , Chromosomal Proteins, Non-Histone/genetics , Chromosomal Proteins, Non-Histone/metabolism , Humans , Protein Domains , RNA Precursors/biosynthesis , RNA Precursors/chemistry , RNA Precursors/genetics , Structure-Activity Relationship , tRNA Methyltransferases/chemistry , tRNA Methyltransferases/genetics , tRNA Methyltransferases/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL
...