ABSTRACT
Two new sesterterpene sulfates, hipposulfates A (1) and B (2), have been isolated from an Okinawan sponge, Hippospongia cf. metachromia and their structures elucidated by interpretation of spectroscopic data. Both compounds contain an enolsulfate functionality. Hipposulfate A (1) showed moderate cytotoxicity.
Subject(s)
Porifera/chemistry , Terpenes/isolation & purification , Animals , Antineoplastic Agents/pharmacology , Drug Screening Assays, Antitumor , HT29 Cells , Humans , Leukemia P388 , Magnetic Resonance Spectroscopy , Sesterterpenes , Terpenes/chemistry , Tumor Cells, CulturedABSTRACT
Five new sesquiterpenes (1-5) having a carbonimidic dichloride or an aldehyde function have been isolated, together with seven known related compounds (6-12), from the sponge Stylotella aurantium. The structures of the new compounds were elucidated from spectral data. The absolute stereochemistry of the previously reported reticulidin A (10) was determined. Four of the new compounds showed cytotoxicity with a range of IC(50) values of 0.1-1 microg/mL against several tumor cell lines.
