ABSTRACT
The association of vascular endothelial growth factor (VEGF) -583C/T variant with recurrent miscarriage (RSM) was investigated in 173 RSM cases and 248 control women. Increased minor allele and genotype frequencies of -583C/T, and reduced serum VEGF concentrations were associated with increased risk of RSM.
Subject(s)
Abortion, Habitual/blood , Abortion, Habitual/genetics , Polymorphism, Genetic , Vascular Endothelial Growth Factor A/blood , Vascular Endothelial Growth Factor A/genetics , Adult , Bahrain , Biomarkers/blood , Case-Control Studies , Chi-Square Distribution , Down-Regulation , Female , Genetic Predisposition to Disease , Heterozygote , Homozygote , Humans , Logistic Models , Odds Ratio , Phenotype , Pregnancy , Risk Assessment , Risk FactorsABSTRACT
PROBLEM: We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM). METHOD OF STUDY: A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method. RESULTS: STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates. CONCLUSION: STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.
