ABSTRACT
The paper presents results obtained at recording under conditions of stresses of different character of activities of enzymes (tyrosinase, DOPA-oxidase, acetylcholinesterase) and level of the catecholamine content in tissues of head and fat body of imago and larvae of housefly from lines with different lifespan. A suggestion is put forward about different mechanisms mediating photoperiodic regulation of metabolism in individuals with different intensity of metabolism.
Subject(s)
Houseflies/metabolism , Longevity/physiology , Photoperiod , Stress, Physiological/physiology , Animals , Catecholamines/metabolism , Fat Body/metabolism , Larva/metabolismABSTRACT
A mutation of wing fragility that was not yet been revealed in adult housefly is described. Criss-cross inheritance of the character of fragility of the wing blade, which indicates localization of gene (fw) for this character in the X chromosome. Phenotypic expression of the mutant allele depends on sex. In male flies, the mutant allele in hemizygous state is expressed at the age of 2-3 weeks and older with penetrance close to 100%. In females, the mutant allele in homozygous state is lethal and in heterozygous state, totally recessive.
Subject(s)
Aging/genetics , Gene Expression Regulation/genetics , Genes, Insect , Houseflies/genetics , Mutation , X Chromosome/genetics , Animals , Female , Male , Wings, AnimalABSTRACT
The research was aimed at studying molecular genetics basis of human longevity. The genotyping of polymorphisms in genes of interleukin 6 (IL-6, 7p21, -572G>C, rs1800796), 10 (IL-10, 1q31-q32, -627C>A, rs1800792), 12, (IL-12B, 5q31.1-q33.1, -1159C>A) and tumor necrosis factor-alpha (TNF-alpha, 6p21.3, -308G>A, rs1800629) from ethnically homogeneous population (Tatars from Bashkortostan Republic) has been carried out. Distributions of allele and genotypes frequencies in different age groups including old men and long-livers have been characterized. Associations have been revealed between age and -627C>A polymorphism of IL-10 gene in men, -572G>C polymorphism of IL-6 gene and -308G>A polymorphism of TNF-alpha gene in women. As a whole the data obtained by us confirm the assumption that polymorphism of cytokine genes can influence on human lifespan.
