1.
Antimicrob Agents Chemother
; 45(10): 2958-60, 2001 Oct.
Article
in English
| MEDLINE
| ID: mdl-11557502
ABSTRACT
We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.
Subject(s)
Drug Resistance, Bacterial/genetics , Mycoplasma hominis/genetics , RNA, Ribosomal, 23S/genetics , Anti-Bacterial Agents/pharmacology , Base Sequence , DNA, Bacterial/analysis , Macrolides , Molecular Sequence Data , Mycoplasma hominis/drug effects , Phenotype , Point Mutation , Sequence Homology, Nucleic Acid
2.
J Antimicrob Chemother
; 45(4): 547-8, 2000 Apr.
Article
in English
| MEDLINE
| ID: mdl-10747837
