Subject(s)
Chronic Urticaria , Urticaria , Antibodies, Monoclonal, Humanized , Basophils , Chronic Disease , Eosinophils , Humans , Urticaria/drug therapyABSTRACT
Wong-type dermatomyositis (DM) is a rare variant characterized by keratotic follicular papules that may mimic pityriasis rubra pilaris. Histopathologic examination shows follicular and non-follicular epidermal invaginations filled with keratin. The diagnosis is often delayed. Twenty-four cases of Wong-type DM have been reported thus far in the literature. Herein, we report the clinical and histopathologic findings of three additional cases in order to raise awareness of the disorder.
Subject(s)
Dermatomyositis/pathology , Diagnosis, Differential , Adolescent , Female , Humans , Middle AgedSubject(s)
Cocaine-Related Disorders/diagnosis , Cocaine-Related Disorders/etiology , Cocaine/adverse effects , Levamisole/adverse effects , Thrombosis/chemically induced , Thrombosis/diagnosis , Vasculitis/chemically induced , Vasculitis/diagnosis , Fluorescent Antibody Technique , Humans , Male , Middle Aged , Thrombosis/complications , Vasculitis/complicationsSubject(s)
Antineoplastic Agents, Phytogenic/adverse effects , Erythema/chemically induced , Ovarian Neoplasms/drug therapy , Paclitaxel/adverse effects , Peritoneal Neoplasms/drug therapy , Antineoplastic Agents, Phytogenic/administration & dosage , Carboplatin/administration & dosage , Female , Humans , Middle Aged , Paclitaxel/administration & dosageSubject(s)
Plasma Cells/pathology , Purpura, Hyperglobulinemic/diagnosis , Skin Diseases/diagnosis , Waldenstrom Macroglobulinemia/diagnosis , Adult , Humans , Macroglobulins/metabolism , Male , Purpura, Hyperglobulinemic/metabolism , Skin Diseases/metabolism , Waldenstrom Macroglobulinemia/metabolismSubject(s)
Breast Neoplasms/radiotherapy , Carcinoma, Ductal, Breast/radiotherapy , Hemangiosarcoma/etiology , Neoplasms, Radiation-Induced/diagnosis , Vascular Neoplasms/etiology , Antineoplastic Agents, Hormonal/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/drug therapy , Carcinoma, Ductal, Breast/surgery , Female , Hemangiosarcoma/surgery , Humans , Mastectomy , Mastectomy, Segmental , Middle Aged , Tamoxifen/therapeutic use , Vascular Neoplasms/surgeryABSTRACT
Cutaneous metastasis of visceral tumors accounts for 2% of skin tumors. We report the case of a 71-year-old male with a smoking history who presented to dermatology department with a violaceous nodule of the right sideburn skin. The lesion was interpreted as an adenocarcinoma that was completely excised and was suspicious for a metastasis. There was a recommendation for additional work-up. At a different institution, a positron emission tomography scan showed a left hilar mass and uptake in the right thyroid. He was then referred to our hospital for tissue diagnosis. Mediastinoscopy with biopsy of the left hilar mass showed metastatic follicular thyroid carcinoma. Subsequently, a thyroid fine needle aspirate showed suspicion for malignancy with similar morphology. Thyroidectomy and central neck dissection showed right thyroid papillary carcinoma extending to one margin and involving the lymph nodes. The left hilar metastasis mass resection showed similar lymph node findings. A re-review of the sideburn excision revealed similar histopathology to the thyroid and mediastinal resection. This case illustrates the opportunity of considering metastatic thyroid carcinoma to skin even in cases which lack the classic cytologic and architectural features of papillary thyroid carcinoma follicular variant.
Subject(s)
Adenocarcinoma, Papillary/secondary , Skin Neoplasms/secondary , Thyroid Neoplasms/pathology , Aged , Humans , MaleABSTRACT
Pemphigus herpetiformis (PH) is a rare autoimmune vesiculobullous disease. It clinically mimics dermatitis herpetiformis and has immunofluorescent findings typical of pemphigus. PH occurs in adults more commonly than children and is often effectively treated with dapsone. We report a case of PH occurring in a 9-year-old boy that was refractory to dapsone and to various other steroid-sparing medications but resolved with methotrexate.
Subject(s)
Dermatitis Herpetiformis/diagnosis , Dermatitis Herpetiformis/drug therapy , Methotrexate/therapeutic use , Pemphigus/diagnosis , Pemphigus/drug therapy , Child , Depsipeptides , Dermatitis Herpetiformis/pathology , Dermatologic Agents/therapeutic use , Diagnosis, Differential , Fusarium , Humans , Male , Pemphigus/pathologySubject(s)
Acantholysis/diagnosis , Carcinoma in Situ/diagnosis , Carcinoma, Squamous Cell/diagnosis , Fibroma/diagnosis , Neoplasms, Complex and Mixed , Skin Neoplasms/diagnosis , Skin/pathology , Acantholysis/pathology , Biomarkers, Tumor/analysis , Biopsy , Carcinoma in Situ/chemistry , Carcinoma in Situ/pathology , Carcinoma, Squamous Cell/chemistry , Carcinoma, Squamous Cell/pathology , Fibroma/chemistry , Fibroma/pathology , Humans , Immunohistochemistry , Male , Middle Aged , Skin/chemistry , Skin Neoplasms/chemistry , Skin Neoplasms/pathologyABSTRACT
Hereditary mucoepithelial dysplasia (HMD) is a rare, autosomal dominantly inherited, multisystem disease thought to be caused by abnormalities in desmosomes and gap junctions. HMD affects the skin, mucosae, hair, eyes and lungs. Nearly all patients clinically display the triad of non-scarring alopecia, well-demarcated mucosal erythema and erythematous intertriginous plaques. Although histopathological findings of mucous membrane epithelium have been well characterized, only three reports have described histopathologic findings in the skin. We report a case with unique histopathological findings not previously reported in HMD.
