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1.
J Cardiovasc Electrophysiol ; 33(3): 473-480, 2022 03.
Article in English | MEDLINE | ID: mdl-35040526

ABSTRACT

INTRODUCTION: The reuse of cardiac implantable electronic devices may help increase access to these therapies in low- and middle-income countries (LMICs). No published data exist regarding the views of patients and family members in LMICs regarding this practice. METHODS AND RESULTS: An article questionnaire eliciting attitudes regarding pacemaker reuse was administered to ambulatory adult patients and patients' family members at outpatient clinics at Centro Nacional Cardiologia in Managua, Nicaragua, Indus Hospital in Karachi, Pakistan, Hospital Carlos Andrade Marín, and Hospital Eugenio Espejo in Quito, Ecuador, and American University of Beirut Medical Center in Beirut, Lebanon. There were 945 responses (Nicaragua - 100; Pakistan - 493; Ecuador - 252; and Lebanon - 100). A majority of respondents agreed or strongly agreed that they would be willing to accept a reused pacemaker if risks were similar to a new device (707, 75%), if there were a higher risk of device failure compared with a new device (584, 70%), or if there were a higher risk of infection compared to a new device (458, 56%). A large majority would be willing to donate their own pacemaker at the time of their death (884, 96%) or the device of a family member (805, 93%). Respondents who were unable to afford a new device were more likely to be willing to accept a reused device (79% vs. 63%, p < .001). CONCLUSIONS: Patients and their family members support the concept of pacemaker reuse for patients who cannot afford new devices.


Subject(s)
Defibrillators, Implantable , Pacemaker, Artificial , Adult , Equipment Reuse , Family , Humans , Surveys and Questionnaires
2.
J Am Heart Assoc ; 3(3): e000388, 2014 May 12.
Article in English | MEDLINE | ID: mdl-24820654

ABSTRACT

BACKGROUND: Percutaneous coronary intervention (PCI) is sometimes performed with the intent to lower cardiovascular risk before high-risk noncardiac surgery (HRNCS). There are limited data on the frequency and outcome of PCIs performed in this setting. METHODS AND RESULTS: We assessed the frequency, characteristics, and in-hospital outcomes of patients undergoing PCI as part of the preoperative workup for HRNCS among all 61 145 elective PCIs performed between 2002 and 2009 at 14 hospitals in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium. Propensity matching was performed to compare outcomes of patients undergoing PCI before HRNCS with all other elective PCI patients. The frequency of PCI before HRNCS was low (4.2%). Patients undergoing PCI before HRNCS were older (67.3 versus 64.9 years, P<0.0001) and had a greater burden of comorbidity. Patients undergoing PCI before HRNCS had an increase in unadjusted major adverse cardiovascular events, postprocedure transfusion, contrast-induced nephropathy, nephropathy requiring dialysis, and same-admission coronary artery bypass graft surgery, but there was no difference in mortality (0.27% versus 0.14%, P=0.11). However, in propensity score-matched samples, there was a significant difference only in nephropathy requiring dialysis. CONCLUSIONS: The incidence of PCI performed in preparation for high-risk noncardiac surgery is low, and these procedures are currently being performed on a highly selected high-risk patient population.


Subject(s)
Percutaneous Coronary Intervention/statistics & numerical data , Preoperative Care/methods , Surgical Procedures, Operative/methods , Aged , Blue Cross Blue Shield Insurance Plans/statistics & numerical data , Cardiovascular Diseases/surgery , Female , Humans , Male , Michigan/epidemiology , Middle Aged , Outcome and Process Assessment, Health Care , Practice Patterns, Physicians'/statistics & numerical data , Preoperative Care/adverse effects , Registries , Risk Reduction Behavior , Surgical Procedures, Operative/adverse effects , Treatment Outcome
4.
Prog Cardiovasc Dis ; 51(1): 31-43, 2008.
Article in English | MEDLINE | ID: mdl-18634916

ABSTRACT

Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by ventricular arrhythmias and structural abnormalities of the right ventricle (RV). ARVD results from progressive replacement of right ventricular myocardium with fatty and fibrous tissue. The precise prevalence of ARVD in the United States has been estimated to be 1 in 5000 of the general population. Recent evidence has made it clear that ARVD is a disease of desmosomal dysfunction. The main management consideration concerns whether to implant an ICD. Catheter ablation of VT is a largely a paliative procedure that should not be considered as an appropriate strategy to eliminate VT or reduce sudden death risk. It is likely that the recent advances in the understanding of the pathophysiologic basis of this condition will result in more targeted treatment approaches in the future.


Subject(s)
Arrhythmogenic Right Ventricular Dysplasia/diagnosis , Arrhythmogenic Right Ventricular Dysplasia/therapy , Arrhythmogenic Right Ventricular Dysplasia/etiology , Defibrillators, Implantable , Electrocardiography , Humans , Magnetic Resonance Imaging , Prognosis
5.
Am J Psychiatry ; 162(12): 2389-91, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16330609

ABSTRACT

OBJECTIVE: This study assessed how many adults completed a research advance directive and the preferences indicated on the completed forms. METHOD: The authors analyzed all 2,371 adults admitted as inpatients to the NIH Clinical Center from March 14 to Sept. 13, 2000. RESULTS: Overall, 11% of adult inpatients completed a research advance directive. Of those who specified preferences, 13% were not willing to participate in future research should they become unable to consent, 76% were willing to participate in research that might help them, 49% were willing to participate in research that would not help them and posed minimal risk, and 9% were willing to participate in research that would not help them and posed greater than minimal risk. CONCLUSIONS: Proposals to allow cognitively impaired adults to participate in research only with a formal advance directive could block important research. More flexible approaches should be considered to protect these individuals.


Subject(s)
Advance Directives/psychology , Attitude , Informed Consent/standards , Research Personnel/psychology , Research Subjects/psychology , Adult , Advance Directive Adherence , Advance Directives/statistics & numerical data , Cognition Disorders/psychology , Female , Hospitalization , Humans , Informed Consent/legislation & jurisprudence , Male , Middle Aged , National Institutes of Health (U.S.)/standards , Patient Advocacy/legislation & jurisprudence , Patient Advocacy/standards , Patient Participation , Proxy/legislation & jurisprudence , Proxy/psychology , Risk Factors , Surveys and Questionnaires , United States
6.
Arch Intern Med ; 165(6): 652-5, 2005 Mar 28.
Article in English | MEDLINE | ID: mdl-15795341

ABSTRACT

BACKGROUND: There is widespread disagreement about the type of consent needed for research with stored biological samples. Many believe consent for each future use is required to respect individuals. Others worry this approach may block important research. METHODS: We analyzed 1670 consent forms signed by research participants at the Warren G. Magnuson Clinical Center, National Institutes of Health, between January 1, 2000, and May 31, 2002, that offer options for future research with participants' biological samples. The research participants were healthy volunteers, family members of affected individuals, and individuals with a broad range of medical conditions enrolled in clinical research studies with and without the prospect of direct medical benefit. RESULTS: Overall, 87.1% of research participants given the option chose to authorize future research on any medical condition. More than 85% permitted unlimited future research with their stored biological samples regardless of sex, age, geographic location, or whether the individual was affected by the disease being studied or a healthy volunteer. Only 6.7% of those given the option to refuse all future research did so. Although African Americans were less likely to permit future research, 75.0% of African Americans still authorized unlimited future research with their samples. CONCLUSIONS: Most research participants authorize the unlimited future research use of their biological samples when given the opportunity to do so. These findings suggest that providing research participants with a simple binary choice to authorize or refuse all future research might allow individuals to control use of their samples, simplify consent forms, and allow important research to proceed.


Subject(s)
Biological Specimen Banks , Biomedical Research , Consent Forms/standards , Informed Consent , Research Subjects/psychology , Chi-Square Distribution , Ethics, Research , Female , Humans , Male , United States
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