Six year follow-up of a patient treated with mandibular symphyseal distraction osteogenesis.

In this report, treatment and long term effects of mandibular symphyseal distraction osteogenesis (MSDO) on dentofacial structures are presented. The distraction device used in the present case was a custom made tooth- and bone-borne distractor. Post-treatment records revealed elimination of mandibular anterior crowding, no temporomandibular joint (TMJ) disorder, no periodontal pathology and no root resorption. Follow-up records taken 6 years after the completion of the treatment indicated no mandibular anterior crowding or TMJ disorder. Treatment and long term results of this case suggest that mandibular widening with distraction osteogenesis is an efficient, safe and stable treatment modality for patients presenting transverse mandibular deficiency and/or mandibular anterior dental crowding. However, large sample studies are required to draw substantial conclusions about the long term effects of the MSDO on dentofacial structures.

Histological evaluation of the effects of bioglass, hydroxyapatite, or demineralized freeze-dried bone, grafted alone or as composites, on the healing of tibial defects in rabbits.

OBJECTIVES: To compare the effectiveness of bioactive glass (BG), natural hydroxyapatite (HA), and demineralized freeze-dried bone (DFDB) in bone defects. METHODS: All animal experiments were conducted in Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey, under the Selcuk University Guidelines for Animal Experimentation, in 2005. Eighteen New Zealand rabbits were used for the experiment. Four cavities were prepared on right and left tibias. The cavities on the right tibia were filled with either BG, HA or DFDB. One cavity was left empty as a control. The cavities on the other tibial bone were grafted with HA(+)BG, HA(+)DFDB, BG(+)DFDB and HA(+)BG(+)DFDB composites. Histological examinations were performed at first, third, and sixth postoperative months. RESULTS: According to histomorphometric findings, the mixture containing HA(+)BG(+)DFDB obtained the best histological results (p<0.05). CONCLUSION: The composite graft of HA, BG and DFDB is more effective than when used as individual agents.

Effects of mandibular symphyseal distraction osteogenesis on mandibular structures.

INTRODUCTION: The purpose of this study was to evaluate the effects of mandibular symphyseal distraction osteogenesis on dental and mandibular skeletal structures with a tooth- and bone-borne distraction device. METHODS: The sample comprised 20 patients, ranging in age from 15.8 to 23.3 years (mean, 20.1 +/- 2.3 years) at the start of treatment. The distraction device was activated 1 mm per day. The device was usually maintained in position about 90 days after surgery. Records were obtained at the start of treatment, at the end of distraction (11.4 +/- 2.2 days after surgery), and at follow-up periods (24.1 +/- 4.2 months after surgery). The records included posteroanterior cephalograms and study casts. The data were analyzed statistically by using the repeated measure analysis of variance and paired t test. RESULTS: Posteroanterior cephalometric analysis demonstrated no significant changes in bigonial widths and ramal angles at the end of distraction period. On the other hand, bimolar widths were significantly increased, whereas bicondylar widths were markedly decreased. The dental cast analysis indicated that the maximum amount of increase was found between the mandibular canines, and the widening effect gradually decreased from the mandibular canines to the second molars. The follow-up data confirmed that the treatment results were stable. CONCLUSIONS: The long-term findings indicate that mandibular symphyseal distraction osteogenesis is an efficient nonextraction treatment alternative for mandibular dental crowding to increase mandibular skeletal and dental arch widths.

Mandibular midline distraction using a simple device.

OBJECTIVE: Mandibular midline distraction osteogenesis represents a new option for creation of intra-arch space in the mandibular arch. The aim of this paper is to introduce a simple device (hyrax expander) and method for mandibular midline distraction. STUDY DESIGN: The sample consisted of 24 patients (mean age: 18.07 years) treated with mandibular midline distraction. Hyrax expanders were used as symphyseal distractors, and distraction procedure was carried out with a rate of 1 mm and rhythm of twice daily. RESULTS: Mandibular midline distraction was completed successfully in all patients and the distraction amount was 7.01 mm. No major complication other than mild mucosal irritation and gingival recession was observed. CONCLUSION: The presented method is a viable option for mandibular midline distraction osteogenesis.

Mandibular midline distraction using a simple device.

OBJECTIVE: Mandibular midline distraction osteogenesis represents a new option for creation of intra-arch space in the mandibular arch. The aim of this paper is to introduce a simple device (hyrax expander) and method for mandibular midline distraction. STUDY DESIGN: The sample consisted of 24 patients (mean age: 18.07 years) treated with mandibular midline distraction. Hyrax expanders were used as symphyseal distractors, and distraction procedure was carried out with a rate of 1 mm and rhythm of twice daily. RESULTS: Mandibular midline distraction was completed successfully in all patients and the distraction amount was 7.01 mm. No major complication other than mild mucosal irritation and gingival recession was observed. CONCLUSION: The presented method is a viable option for mandibular midline distraction osteogenesis.

Analysis of chromosomes 8 and 17 aneuploidies in laryngeal squamous cell carcinoma by fluorescence in situ hybridization.

OBJECTIVES/HYPOTHESIS: The objectives were to investigate chromosomes 8 and 17 numerical aberrations by using fluorescence in situ hybridization in laryngeal squamous cell carcinoma and also to determine whether there is any association between chromosomes 8 and 17 aneuploidies and TNM classification and subgroups of laryngeal squamous cell carcinomas. STUDY DESIGN: Descriptive study. METHODS: Tumor and control samples were taken from 23 patients with LSCC by surgical operation. Fluorescence in situ hybridization analysis with chromosomes 8- and 17-specific alpha-satellite DNA probes was performed on the interphase nuclei. RESULTS: The percentages for chromosomes 8 and 17 aneuploidies were 33% (SD = 25.7%) (median value, 26.2%; range, 3.5%-81.8%) and 19.2% (SD = 15.8%) (median value, 9.8%; range, 3.6%-63.7%), respectively. There was a significant difference between stage 2 and stage 3 (P <.05) and between stage 2 and stage 4 for chromosome 8 aneuploidy (P <.05) but not for chromosome 17 aneuploidy (P >.05). There was also a significant difference for the T classification for chromosome 8 aneuploidy (P <.05) but not for chromosome 17 (P >.05). CONCLUSION: Chromosome 8 aneuploidy may be related to stage and T classification of laryngeal squamous cell carcinoma and its progression.

Accidental displacement of impacted maxillary and mandibular third molars.

Displacement of impacted third molars is frequently mentioned in oral and maxillofacial surgery textbooks, but rarely reported. However, should this complication arise in general practice, the clinician should not embark on potentially complicated and hazardous surgical procedures to retrieve the displaced tooth. Administration of prophylactic broad spectrum antibiotics and urgent referral to an oral and maxillofacial surgeon, is recommended.