ABSTRACT
OBJECTIVE: To evaluate the efficacy of Anti Viral 2 (AV2) in the regression of moderate and severe colposcopic lesions, when com- pared to placebo. MATERIALS AND METHODS: Women, aged over 18 years with a colposcopic diagnosis of moderate to severe dysplasia were randomized to receive either two applications of AV2 or placebo within four days. Both examining physician and patients were blinded to the treatment option. Follow-up colposcopy was performed on days 11, 2 1, and 60. RESULTS: A total of 50 patients were enrolled in this study. There was no statistically significant difference in screening entry criteria between the two groups. The results showed that the application of AV2 yielded a reduction of more than 50% for 21 out of 28 (75%) patients who received the active treatment versus a 0% for the comparable placebo group (p < 0.00 1). CONCLUSIONS: The authors conclude that AV2 can have a place in the treatment of colposcopically-detected cervical lesions. Due to the proven broad spectrum antiviral activity of AV2, a plausible explanation is that the lesions regress due to deactivation of the virus. Further trials with larger numbers and detailed cytology and histology are needed to confirm these results.
Subject(s)
Antiviral Agents/therapeutic use , Colposcopy , Uterine Cervical Dysplasia/drug therapy , Adult , Double-Blind Method , Female , HumansABSTRACT
Introduction. Le cancer du col uterin demeure un probleme de sante publique dans les pays endeveloppement; a cause de son diagnostic tardif et de son mauvais pronostic. Sa prevention secondaire se fait par le depistage des lesions precancereuses et cancereuses du col. Objectif. Evaluer la faisabilite et les performances diagnostiques de l'IVA par rapport a la colposcopie prise comme test de reference. Methodologie. Cette etude transversale a ete realisee aux Cliniques Universitaires de Kinshasa; de juillet 2009 a avril 2010; aupres de 350 femmes agees de 25 a 75 ans recues en consultation de gynecologie. Apres un consentement eclaire; les sujets ont subi un examen clinique comprenant l'anamnese; l'examen physique general; et l'examen gynecologique. Le test a l'IVA a ete realise a l'examen au speculum; suivi de la colposcopie. Resultats. Sur 350 femmes; 70 (20) ont ete positives a l'IVA. A la colposcopie des lesions intramalpighiennes de bas grade ont ete constatees chez 57 patientes (16;3) ; des lesions intramalpighiennes de haut grade chez 7 (2); et des lesions de cancer chez 9 patientes (2;6) . La sensibilite; la specificite; les valeurs predictives positive et negative de l'IVA par rapport a la colposcopie; ont ete respectivement de 89; 98; 93et 97. Conclusion. Compte tenu de sa sensibilite et sa specificite excellentes; l'IVA apparait comme une technique fiable et adapte pour le depistage du cancer du col uterin en situation de precarite
