ABSTRACT
A 5-year-old girl with generalized verrucous hyperkeratosis consulted the dermatologist for diagnosis and therapy. Further physical and mental development were normal. Gene analysis of keratin 1 and 10 was negative. According to the clinical findings, the diagnosis ichthyosis hystrix was made. Treatment with oral vitamin-A was suggested to the family.
Subject(s)
Ichthyosis/diagnosis , Vitamin A/therapeutic use , Child, Preschool , Diagnosis, Differential , Female , Humans , Ichthyosis/drug therapy , Physical Examination , Skin/pathologyABSTRACT
BACKGROUND: Primary cutaneous CD30+ anaplastic large-cell lymphoma is a rare form of non-Hodgkin's lymphoma, which is restricted to the skin. CASE DESCRIPTION: A 50-year-old man presented with an asymptomatic tumorous area in the groin that had appeared within the previous week, and a longer history of a transient red, flaking area in the popliteal space. Histopathological findings were consistent with CD30+ anaplastic large-cell lymphoma. Staging demonstrated no extracutanous spread. The skin lesions disappeared without treatment within 3 months. CONCLUSION: Primary cutaneous CD30+ anaplastic large-cell lymphoma is a rare condition. It has a histopathological picture of a diffuse proliferation of large atypical anaplastic cells, suggesting an unfavourable disease course. However, this condition is characterised by a indolent course and favourable prognosis since spontaneous complete regression can occur.
Subject(s)
Antigens, Neoplasm/analysis , Ki-1 Antigen/analysis , Lymphoma, T-Cell, Cutaneous/immunology , Skin Neoplasms/immunology , Humans , Male , Middle Aged , Remission, SpontaneousABSTRACT
We aimed to investigate volumetry of the medial temporal lobe in patients with subjective memory complaints without any cognitive impairment. This study included 20 patients with subjective memory complaints and normal cognitive function and 28 controls without memory complaints. Volumes of the hippocampus and parahippocampal gyrus (PHG) were measured using coronal T1-weighted MR images. Cognitive functions were assessed using the Cambridge Cognitive Examination. Depressive symptoms were assessed using the Geriatric Depression Scale. Differences between groups were analysed using t-tests. Patients with subjective memory complaints had a higher education and more depressive symptoms than controls ( p < 0.01). Moreover, they had smaller left hippocampal volumes than controls ( p < 0.01). There were no differences between groups in the volume of the right hippocampus or PHG. There was a moderate association between the volume of left hippocampus and left PHG and memory-score (r = 0.32, p = 0.03; r = 0.34, p = 0.02). We concluded that memory complaints in patients without any cognitive impairment were associated with smaller left hippocampal volumes and more depressive symptoms. These preliminary results suggest that memory complaints may reflect minimal brain deficits associated with impending dementia, depression or a combination of both disorders.
