ABSTRACT
The bioavailability and pharmacokinetics of mefenamic acid was studied in alloxan-diabetic rabbits. Mefenamic acid in plasma was assayed by high performance liquid chromatography. A paired t-test for normal and alloxan treated rabbits revealed a significant decrease in all the bioavailability and disposition kinetic parameters of mefenamic acid during diabetes was observed in the present study. The altered bioavailability and disposition of mefenamic acid in the diabetic state will require adjustment of the dosage regimen prescribed for diabetics in a clinical setting.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Diabetes Mellitus, Experimental/metabolism , Mefenamic Acid/pharmacokinetics , Animals , Biological Availability , Female , Male , RabbitsABSTRACT
The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.
Subject(s)
Dehydration/metabolism , Erythromycin/pharmacokinetics , Animals , Blood Glucose/analysis , Blood Proteins/analysis , Erythromycin/administration & dosage , Erythromycin/blood , Erythromycin/toxicity , Hydrogen-Ion Concentration , Injections, Intravenous , Lipids/blood , Male , RabbitsABSTRACT
The present work has been done in an attempt to evaluate the hypoglycemic effect of Chlorpropamide in the presence of aspirin. Diabetiogenic effect of Alloxan was utilized which produced an Insulin-Dependent Diabetic State in the animals. Diabetic animals were given oral Chlorpropamide (100 mg/kg body weight) and it was seen that the drug reduced the blood sugar values although not to a significant level. Later the animals were given aspirin (30 mg/kg body weight) alongwith the daily dose of Chlorpropamide and a more significant reduction of blood sugar level took place.
