[The prognostic value of activation of the hypophyseal and adrenal cortical systems in severe heart failure]. / Valore prognostico dell'attivazione dei sistemi ipofisario e corticosurrenale nell'insufficienza cardiaca severa.

The aim of this study was to evaluate changes of pituitary and adrenal cortex hormones in patients with congestive heart failure according to NYHA functional classes and to detect possible prognostic effects of these changes. We studied 101 patients: 60 with congestive heart failure, in absence of clinical, anamnestic signs of endocrine diseases (Group I, 37 males, 23 females; mean age 62 +/- 7.2 years) and 41 patients with cardiac diseases without signs of congestive heart failure, homogeneous for age and sex (Group II, 23 males, 18 females; mean age 61 +/- 8.5 years). All patients were submitted to a 12 month follow-up in order to evaluate hormonal changes. Hormonal study was performed through radioimmunoassay technique. Plasma levels of insulin, growth hormone (GH), adrenocorticotropine (ACTH), cortisol and prolactin (PRL) were evaluated. We observed in Group I a significant increase of cortisol and GH with respect to Group II. No significant difference occurred in plasma levels of insulin, PRL and ACTH. Subdividing Group I patients on the basis of NYHA classification, significant increase (p < 0.05) in cortisol and GH was observed in IV NYHA functional class with respect to II and III NYHA ones. Moreover a significant reduction (p < 0.02) of ACTH in IV NYHA functional class was also detected. Plasma levels of cortisol and GH were also significantly higher in patients dead during the follow-up with respect to survivors. Statistical analysis showed a linear negative correlation between cortisol and ACTH in III NYHA functional class (p < 0.03), a negative correlation between cortisol and radius/thickness ratio (p < 0.03) and between cortisol and serum glutamic oxalacetic transaminase (p < 0.05). In IV NYHA functional class a significant negative correlation between cortisol and shortening fraction (p < 0.05) also occurred. Plasma levels of cortisol and GH were significantly higher (p < 0.05) in IV NYHA functional class with respect to II and III classes, with associated significant reduction of shortening fraction (p < 0.05). Our data confirm that, besides catecholamines and renin-angiotensin-aldosterone system, in the presence of severe congestive heart failure (IV NYHA functional class), a significant activation of pituitary and adrenal cortex hormones occurs. It is still an open question whether this activation plays a pathogenetic role in the evolution of heart failure, but the significant increase of these hormones (GH and cortisol) seems to be significant negative prognostic markers.

[Whole body irradiation in conditioning for bone marrow transplantation. Experiences with 35 cases of leukemia]. / L'irradiazione corporea totale nel condizionamento al trapianto di midollo osseo. Esperienza su 35 casi di leucemia.

Total body irradiation, carried out in two different regimens (10 Gy single dose; 200 cGy X 5 fractions) has been used in 35 patients with acute leukaemia or chronic leukaemia in chronic or accelerated phase, in preparation for bone marrow transplantation. The dose rate was in the range of 2-4 cGy . min-1. No lung shielding was adopted. The role of total body irradiation in the development of interstitial pneumonitis is considered. Rather than to the regimen of total body irradiation--single dose or five fractions--the incidence of interstitial pneumonitis seems to be related to other factors; mainly to the presence of Graft-versus-Host-Disease: Five patients out of six with III or IV grade GvHD, developed interstitial pneumonitis; only one patient out of twenty without GvHD or with a low grade GvHD developed interstitial pneumonitis.