Frequency of nonaspirin NSAID-relevant coexisting medical conditions in the primary-care setting: a retrospective database review.

BACKGROUND: Coexisting medical conditions and concomitant medications contribute to treatment challenges primary-care professionals (PCPs) face daily. The current study assessed the extent and distribution of nonaspirin NSAID-relevant coexisting medical conditions of interest (CMCOI) in patients visiting PCPs. METHODS: This retrospective database review analyzed data from three large health-care claim databases to identify the frequency of nonaspirin NSAID-relevant CMCOI among adults aged ≥18 years with a PCP visit in 2013. Claim databases employed were the Truven Health MarketScan® Commercial Claims and Encounters database, representative of the privately insured (PI) population; Truven Health MarketScan Multi-State Medicaid, representative of the Medicaid population (Medicaid); and Truven MarketScan Medicare Supplemental, representative of the Medicare population with employer-based supplemental Medicare insurance (Medicare-Supplement). Nonaspirin NSAID-relevant CMCOI, asthma, cardiovascular risk factors, gastrointestinal bleeding risk factors, and renal insufficiency were chosen based on US NSAID over-the-counter Drug Facts label warnings. Frequency of CMCOI was determined for those without and with a musculoskeletal diagnosis. RESULTS: In each database, ≥19% (19.0% PI, 29.9% Medicaid, 33.6% Medicare-Supplement) had a musculoskeletal diagnosis. A greater proportion of individuals with a musculoskeletal diagnosis had one or more CMCOI compared with those without a musculoskeletal diagnosis (61.3% vs 50.4% PI, 78.1% vs 66.8% Medicaid, 87.1% vs 82.3% Medicare-Supplement). The frequency of one or more CMCOI increased with age in each database. Across databases among CMCOI, cardiovascular risk factors were most common, followed by gastrointestinal bleeding risk factors, and proportions were higher among those with a musculoskeletal diagnosis. CONCLUSION: These data confirm the high frequency of nonaspirin NSAID-relevant CMCOI among patients presenting to PCPs for musculoskeletal diagnosis, as well as among older patients. These analyses reinforce the critical role health-care professionals can play in identifying patients with nonaspirin NSAID-relevant CMCOI, providing those patients with ongoing guidance on appropriate choice and use of over-the-counter analgesics, and educating patients about the impact aging, health status, concomitant conditions, and medicines have on selection of all medicines, including analgesics.

Correction: Author contributions to ecological publications: What does it mean to be an author in modern ecological research?

[This corrects the article DOI: 10.1371/journal.pone.0179956.].

Author contributions to ecological publications: What does it mean to be an author in modern ecological research?

Authorship is a central element of scientific research carrying a variety of rewards and responsibilities, and while various guidelines exist, actual author contributions are often ambiguous. Inconsistent or limited contributions threaten to devalue authorship as intellectual currency and diminish authors' responsibility for published content. Researchers have assessed author contributions in the medical literature and other research fields, but similar data for the field of ecological research are lacking. Authorship practices in ecological research are broadly representative of a variety of fields due to the cross-disciplinary nature of collaborations in ecological studies. To better understand author contributions to current research, we distributed a survey regarding co-author contributions to a random selection of 996 lead authors of manuscripts published in ecological journals in 2010. We obtained useable responses from 45% of surveyed authors. Reported lead author contributions in ecological research studies consistently included conception of the project idea, data collection, analysis, and writing. Middle and last author contributions instead showed a high level of individual variability. Lead authorship in ecology is well defined while secondary authorship is more ambiguous. Nearly half (48%) of all studies included in our survey had some level of non-compliance with Ecological Society of America (ESA) authorship guidelines and the majority of studies (78%) contained at least one co-author that did not meet International Committee of Medical Journal Editors (ICMJE) requirements. Incidence of non-compliance varied with lead author occupation and author position. The probability of a study including an author that was non-compliant with ESA guidelines was lowest for professor-led studies and highest for graduate student and post doctoral researcher-led studies. Among studies with > two co-authors, all lead authors met ESA guidelines and only 2% failed to meet ICMJE requirements. Middle (24% ESA, 63% ICMJE) and last (37% ESA, 60% ICMJE) authors had higher rates of non-compliance. The probability of a study containing a co-author that did not meet ESA or ICMJE requirements increased significantly with the number of co-authors per study although even studies with only two co-authors had a high probability of non-compliance of approximately 60% (ICMJE) and 15 to 40% (ESA). Given the variable and often limited contributions of authors in our survey and past studies of other research disciplines, institutions, journals, and scientific societies need to implement new approaches to instill meaning in authorship status. A byline approach may not alter author contributions but would better define individual contributions and reduce existing ambiguity regarding the meaning of authorship in modern ecological research.

Endangered species: Pan-Atlantic leatherback turtle movements.

The overall extent of habitat use by leatherback turtles in the North Atlantic, and hence their possible interactions with longline fisheries, is unknown. Here we use long-term satellite telemetry to reveal that leatherbacks range throughout the North Atlantic, indicating that closing limited areas to longline fisheries will probably have only partial success in reducing turtle bycatch. Although turtles dive very deeply on occasion (one descended to a maximum depth of 1,230 metres, which represents the deepest dive ever recorded for a reptile), they generally restrict their diving to less than 250 metres, which increases the chance that they will encounter longline hooks.