Review of visceral throat and chest disorders causing nonodontogenic orofacial pain.

BACKGROUND: The purpose of this narrative review was to show that referred orofacial pain can be the chief symptom or a prominent symptom of visceral diseases of the chest and throat, with implications for dental and medical practice. TYPES OF STUDIES REVIEWED: A search of PubMed was performed to identify dentally relevant clinical case reports and case series using the following terms: jaw pain, orofacial pain, toothache, temporomandibular disorders, otalgia, neuralgia, and neuropathicpain crossed with angina, myocardial infarction, carotid artery, esophagus, mediastinum, thyroid, heart, pericardium, aorta, lung, thymus gland, and stomach. RESULTS: Numerous acute, visceral disorders of the throat and chest have been reported to produce pain in the orofacial region, which may be difficult to distinguish from dental-related diseases on the basis of symptoms alone. Chest organs and structures reported to cause such pain include the heart, aorta, esophagus, stomach, lungs, and mediastinum. Throat organs and structures reported to cause pain in the orofacial region include the thyroid gland, carotid arteries, and vagus and glossopharyngeal nerves. Coronary artery diseases, aortic and carotid dissection, mediastinal tumors, subacute thyroiditis, and gastroesophageal reflux disease have a predilection for referring pain orofacially. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Misdiagnosis of referred visceral orofacial pain can lead to delayed diagnosis and unnecessary treatment. Dentists can play a key role in the management of these conditions by means of ruling out odontogenic facial pain, promptly referring patients to medical specialists, and educating patients. Future research is needed to determine the incidence and mechanism of orofacial pain in these disorders. Visceral pain referred to the orofacial region may not be as rare a phenomenon as is sometimes assumed.

The receptive field for visceral pain referred orofacially by the vagus nerves.

BACKGROUND: The nociceptive receptive field of the vagus nerves in animals includes virtually the entire thoracic, abdominal and laryngopharyngeal regions. However, the role of the vagus nerves in the transmission of visceral pain in humans, with the exception of pain from coronary artery diseases, is believed to be insignificant. AIM: The purpose of this report is to map out the clinical visceral pain receptive field of the vagus nerves relative to its nociceptive counterpart in animals. MATERIALS AND METHODS: The PubMed database and PMC were searched for case reports of patients with orofacial pain believed by the author(s) of the article to be referred from underlying non-cardiac thoracic, laryngopharyngeal or abdominal diseases. Reports of diseases for which non-neural explanations for the orofacial spread of pain were suggested were excluded. RESULTS: A total of 52 case reports of jaw pain and/or otalgia referred from laryngopharyngeal and noncardiac thoracic sources were discovered. In addition, a multicenter prospective study found that 25.8% of more than 3,000 patients with thoracic aortic dissection experienced pain in the head and neck region. In stark contrast, no case reports of orofacially referred pain from abdominal diseases were found. DISCUSSION: The results indicate that the laryngopharyngeal and thoracic portions of the vagal receptive field are capable of referring pain orofacially while the abdominal portion is not. The roles of the somatotopic organization of the trigeminal sub nucleus caudalis and neuromodulation in this referral of pain were discussed. CONCLUSION: Referred orofacial pain can lead to delayed diagnosis and poorer outcome in visceral diseases.

Current status of potential bisphenol toxicity in dentistry.

Bisphenols are chemical components found in dental composites and sealants. Similar compounds also can be found in baby bottles, food can liners, and even drinking water. Bisphenols have gained attention recently because they, like other natural and synthetic compounds, including hormone-based drugs and soybean products, have the capacity to mimic the actions of the hormone estrogen in living cells and animals. Such estrogenic activity has been linked to a variety of health problems, including breast and prostate cancer, metabolic disorders, and reproductive dysfunction. In early 2010, the FDA issued a report stating that there are some concerns about the safety of bisphenols in food products and called for more research on bisphenol toxicity. At present, no regulatory or professional organization has expressed concern about health effects of bisphenols in dental materials.

Toothache referred from heart disease and lung cancer via the vagus nerve.

New epidemiologic evidence suggests that referred craniofacial pain in coronary heart disease is more common than previously believed. Current medical reports suggest that in addition to coronary disease, thoracic disorders such as aortic dissection, pericarditis, and lung cancer can cause referred craniofacial pain. Recent physiologic evidence from animals and humans suggests that the vagus nerve mediates this referral of cardiac pain to the maxillofacial region. This article discusses the critical role of the dentist in patient education and recognition of referred head and neck pain in thoracic disease, in relation to the need for prompt medical treatment for these life-threatening conditions.