1.
Org Lett
; 6(8): 1285-8, 2004 Apr 15.
Article
in English
| MEDLINE
| ID: mdl-15070318
ABSTRACT
Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral centers alpha or beta at the C-5 position do not detract from diastereoselectivity of the Jacobsen-Strecker reaction. [reaction: see text]