Artificial Intelligence-Based Non-invasive Differentiation of Distinct Histologic Subtypes of Renal Tumors With Multiphasic Multidetector Computed Tomography.

INTRODUCTION: With rising cases of renal cell carcinoma (RCC), precise identification of tumor subtypes is essential, particularly for detecting small, heterogenous lesions often overlooked in traditional histopathological examinations. This study demonstrates the non-invasive use of deep learning for Histopathological differentiation of renal tumors through quadriphasic multidetector computed tomography (MDCT). PATIENTS AND METHODS: This prospective longitudinal study includes 50 subjects (32 males, 18 females) with suspected renal tumors. A deep neural network (DNN) is developed to predict RCC subtypes using peak attenuation values measured in Hounsfield Units (HUs) obtained from quadriphasic MDCT scans. The network then generates confidence scores for each of the four primary subtypes of renal tumors, effectively distinguishing between benign oncocytoma and various malignant subtypes. RESULTS: Our neural network accurately distinguishes Renal tumor subtypes, including clear cell, papillary, chromophobe, and benign oncocytoma, with a confidence score of 68% with the network's diagnosis aligning with Histopathological examinations. Our network was also able to accurately classify RCC subtypes on a synthetically generated dataset with 20,000 samples. CONCLUSION: We developed an artificial intelligence-based RCC subtype classification technique. Our approach is non-invasive and has the potential to transform the methodology in Renal oncology by providing accurate and timely diagnostic information and enhancing clinical decisions.

Virtual Reality Simulation: Evaluating an Experiential Tool for the Clinical Application of Pathophysiology.

At our medical school, MS3 students experience minimal patient contact. Our research shows that virtual reality simulation (VRS) supports students' transition back to patient care by increasing post-intervention confidence in clinical decision-making, management, and patient communication. VRS shows potential to teach pathophysiology, and bridges clinical and basic science instruction.

Microvascular Responsiveness to Pulsatile and Nonpulsatile Flow During Cardiopulmonary Bypass.

BACKGROUND: Pulsatile perfusion may offer microcirculatory advantages over conventional nonpulsatile perfusion during cardiopulmonary bypass (CPB). Here, we present direct visual evidence of microvascular perfusion and vasoreactivity between perfusion modalities. METHODS: A prospective, randomized cohort study of 20 high-risk cardiac surgical patients undergoing pulsatile (n = 10) or nonpulsatile (n = 10) flow during CPB was conducted. Changes in sublingual mucosal microcirculation were assessed with orthogonal polarization spectral imaging along with near-infrared spectroscopic indices of thenar muscle tissue oxygen saturation (StO2) and its recovery during a vascular occlusion test at the following time points: baseline (T0), 30 minutes on CPB (T1), 90 minutes on CPB (T2), 1 hour after CPB (T3), and 24 hours after CPB (T4). RESULTS: On the basis of our scoring scale, a shift in microcirculatory blood flow occurred over time. The pulsatile group maintained normal perfusion characteristics, whereas the nonpulsatile group exhibited deterioration in perfusion during CPB (T2: 74.0% ± 5.6% versus 57.6% ± 5.0%) and after CPB (T3: 76.2% ± 2.7% versus 58.9% ± 5.2%, T4: 85.7% ± 2.6% versus 69.8% ± 5.9%). Concurrently, no important differences were found between groups in baseline StO2 and consumption slope at all time points. Reperfusion slope was substantially different between groups 24 hours after CPB (T4: 6.1% ± 0.6% versus 3.7% ± 0.5%), indicating improved microvascular responsiveness in the pulsatile group versus the nonpulsatile group. CONCLUSIONS: Pulsatility generated by the roller pump during CPB improves microcirculatory blood flow and tissue oxygen saturation compared with nonpulsatile flow in high-risk cardiac surgical patients, which may reflect attenuation of the systemic inflammatory response and ischemia-reperfusion injury.

Association between preoperative statin use and acute kidney injury biomarkers in cardiac surgical procedures.

BACKGROUND: Acute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature. METHODS: We conducted a multicenter prospective cohort study of 625 adult patients undergoing elective cardiac operations. All patients were taking statins and were grouped according to whether statins were continued or held in the 24 hours before operation. The primary outcome was AKI as defined by a doubling of serum creatinine or dialysis. The secondary outcome was the peak level of several kidney injury biomarkers. The results were adjusted for demographic and clinical factors. RESULTS: Continuing (vs holding) a statin before operation was not associated with a lower risk of AKI, as defined by a doubling of serum creatinine or dialysis (adjusted relative risk [RR] 1.09; 95% confidence interval [CI] 0.44, 2.70). However, continuing a statin was associated with a lower risk of elevation of the following AKI biomarkers: urine interleukin-18, urine neutrophil gelatinase-associated lipocalin, urine kidney injury molecule-1, and plasma neutrophil gelatinase-associated lipocalin (adjusted RR 0.34; 95% CI 0.18, 0.62), (adjusted RR 0.41; 95% CI 0.22, 0.76), (adjusted RR 0.37; 95% CI 0.20, 0.76), (adjusted RR 0.62; 95% CI 0.39, 0.98), respectively. CONCLUSIONS: Statins may prevent kidney injury after cardiac operations, as evidenced by lower levels of kidney injury biomarkers.

Using a shared governance structure to evaluate the implementation of a new model of care: the shared experience of a performance improvement committee.

Sustaining change in the behaviors and habits of experienced practicing nurses can be frustrating and daunting, even when changes are based on evidence. Partnering with an active shared governance structure to communicate change and elicit feedback is an established method to foster partnership, equity, accountability, and ownership. Few recent exemplars in the literature link shared governance, change management, and evidence-based practice to transitions in care models. This article describes an innovative staff-driven approach used by nurses in a shared governance performance improvement committee to use evidence-based practice in determining the best methods to evaluate the implementation of a new model of care.

A novel approach to pain management in persons with sickle cell disease.

Sickle cell disease (SCD) is an illness that affects red blood cells. Patients with SCD can have chronic pain or acute pain episodes, which must be managed with medical therapy. Although many options are available for pain management, utilization of subcutaneous patient-controlled analgesia for pain management has positive outcomes for patients in both pain management and satisfaction.

Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma.

Patients with cutaneous T-cell lymphoma (CTCL) have a rare, disfiguring, and life-threatening subtype of non-Hodgkin lymphoma primarily localized to the skin. Their immune systems are altered and their skin is compromised. In addition, they are highly prone to infections-the most common cause of death in patients with this disease. Patients presenting with early-stage disease involvement typically are treated with topical therapies; patients with advanced-stage and recurrent disease require systemic treatment. Specialized knowledge is required by oncology healthcare providers to manage the wide array of symptoms experienced by these patients as a part of the natural course of this disease. A new drug, romidepsin, approved by the U.S. Food and Drug Administration, is indicated in the treatment of relapsed CTCL. The authors discuss use of romidepsin in the context of CTCL and the information needed to safely administer romidepsin and manage its side effects.

The meaning of attention-deficit/hyperactivity disorder medication and parents' initiation and continuity of treatment for their child.

OBJECTIVE: The aim of this study was to examine parents' early understanding of medication for attention-deficit/hyperactivity disorder (ADHD) in relation to decisions to initiate and continue treatment for their child. METHODS: Qualitative, semistructured telephone interviews were conducted with 48 parents of children newly diagnosed with ADHD. Parents were recruited from inner city, outpatient primary care, and mental health clinics affiliated with a large university hospital. Data were analyzed using grounded theory. RESULTS: Parents' initial perspectives of the appropriateness, anticipated effects, and symbolic meaning of medication were classified by four typologies (illness oriented, problem oriented, generally acceptable, unacceptable). In this sample, 29% of parents believed medication was required to treat the illness and 20% believed medication was unacceptable. Except for the unacceptable group, nearly all of the parents in the other groups initiated medication shortly after diagnosis. More than 80% of the illness- and problem-oriented groups used medication at 6 months; this fell to 64% and 78%, respectively, at 12 months. Only half of the unacceptable group ever used medication for their child. CONCLUSIONS: Parents' views of ADHD medication may be predictive of continuity of treatment. Increasing physician awareness of parent preferences for managing their child's ADHD problems may lead to care management plans that maximize continuity.

A pilot study to assess frequency of carriage and routes of acquisition of Staphylococcus aureus by healthy infants.

Healthy infants frequently acquire Staphylococcus aureus colonization; however, the modes of transmission are not well defined. In this study, 8 of 23 (35%) infants cultured at age 2 weeks acquired S aureus carriage, but only 1 infant had a family member with nasal carriage of the same clone, suggesting that sources other than colonized family members may account for a significant proportion of cases.

The virtual ICU (vICU): a new dimension for critical care nursing practice.

The virtual or remote intensive care unit is a redesigned model of care that uses state-of-the-art technology to leverage the expertise and knowledge of experienced caregivers over a large group of patients in multiple intensive care units. The registered nurse working in this environment, or eRN, is an expert clinician familiar with evidence-based clinical initiatives that need to occur at the bedside to optimize outcomes for patients. The eRN assists the bedside team by providing a second layer of quality and safety. As the use of this technology continues to grow, a new dimension for critical care nursing practice is emerging that has dramatic implications for the future.

Working in an eICU unit: life in the box.

This ethnographic study of the VISICU eICU (VSISCU, Inc., Baltimore, MD) work environment in a large midwestern health care system describes everyday life working in a telemedicine intensive care. Data were gathered through 60 hours of observation and formal interviews of eICU clinician team members. Working in the remote telemedicine center, often referred to as the "Box", is like working in an air traffic control center. Remote oversight and effective communication ensure the best possible outcomes to support the bedside intensive care unit team.

Effect of lidocaine gel on povidone-iodine antisepsis and microbial survival.

PURPOSE: To determine whether the use of lidocaine gel prior to povidone-iodine antisepsis is associated with increased microbial survival. SETTING: Ophthalmology Department, Madigan Army Medical Center, Fort Lewis, Washington, USA. METHODS: A standardized suspension of Staphylococcus epidermidis was used to inoculate 5 blood agar plates that served as a control. A second group of 5 blood agar plates was inoculated, and then lidocaine gel was applied to the plates. A third group of 5 blood agar plates was inoculated, lidocaine gel was applied, and then povidone-iodine 5% was applied and allowed to cover the plates. A fourth group of 5 blood agar plates was inoculated, and then povidone-iodine 5% was allowed to cover the plates. Cultures of Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus influenza were tested in a similar fashion. Microbial growth was evaluated after 24 hours. RESULTS: The number of colony forming units (CFUs) was similar in the control group and the S epidermidis, S aureus, and P aeruginosa lidocaine only and lidocaine with povidone-iodine groups. In these groups, each plate grew between 200 CFUs and 300 CFUs. In the Haemophilus influenza series, the lidocaine with povidone-iodine group had fewer CFUs than the control group. In all 4 series, the povidone-iodine only group had the least amount of CFUs, ranging from 0 to 6. CONCLUSIONS: The use of lidocaine gel before application of povidone-iodine 5% resulted in decreased effectiveness of antisepsis and increased microbial survivability. The increase in microbial survivability may increase the risk for postoperative infection in ocular surgery performed under topical anesthesia.

Coronary artery spasm: a rare but important cause of postoperative myocardial infarction.

Myocardial infarction that is attributed to native coronary artery spasm in the early postoperative phase has rarely been documented. We report three cases of postoperative myocardial infarction secondary to angiographically demonstrated coronary spasm. Native coronary artery spasm is a rare, but important cause of postoperative ischemia and infarction. Suspicious electrocardiographic changes warrant consideration of transesophageal echocardiography to detect unexpected wall motion abnormalities. Established treatments include intravenous or intracoronary infusion of nitroglycerin and calcium channel antagonists, although several new therapeutic agents may also be beneficial. Prompt coronary angiography is the only definitive modality for early diagnosis and targeted treatment.

Parental attitudes and involvement in psychopharmacological treatment for ADHD: a conceptual model.

Current evidence strongly points to significant parental concerns about exposing their children to psychopharmacological medications. This is true even with stimulant medications for attention deficit/hyperactivity disorder (ADHD), an evidence-based treatment for children. Theory and prior evidence would predict that parents' hesitancy to give their children psychopharmacological medication is likely due to what they hear from family and friends about medication's untoward effects. That social networks impact problem definition, treatment evaluation, and service use is well established. However, it is not known how parents make treatment decisions as they cope with the reality that their child might benefit from psychopharmacological medication. The qualitative research described in this paper addresses this gap. A conceptual model is presented that describes parents' treatment decisions and participation in their children's care as they shift from parenting a child with behavioural problems to parenting a child who eventually requires psychopharmacological medication. Further research is needed to evaluate how this model can offer a more comprehensive understanding of how parents respond to a diagnostic label and various treatment options. It is hoped that this research will stimulate innovative approaches for tailoring treatments that are respectful of the individual needs of children and their families.

Traumatic innominate artery disruption and aortic valve rupture.

Rapid deceleration injury causing blunt thoracic trauma can result in injury to the thoracic aorta. Rupture of the aortic isthmus is the most common presentation; however, injury can occur more proximally in the arch vessels or the aortic root. We present an unusual case of simultaneous innominate artery disruption with aortic valve rupture after a motor vehicle accident, and we discuss issues surrounding the diagnosis and operative management of this rare, but life-threatening condition.

Nosocomial pressure ulcer rates in critical care: performance improvement project.

Assessment, monitoring, and prevention of pressure ulcers in the hospitalized patient are required standards of care. The annual nosocomial pressure ulcer (NPU) rates for the adult intensive care units at our facility had trended up to 33% from 14% over a 13-month period. Our performance improvement team decided to track 5 variables that may have contributed to the increased incidence of NPU. Weekly skin care rounds were conducted to collect data, educate staff, and reinforce skin care policy and standards of care. Data analysis revealed 3 areas that required further emphasis with nursing staff: daily assessment with the Braden Scale, prevention of NPU beginning on the day of hospital admission, and the effect of sedation on patient mobility. Implementation of appropriate interventions targeted to specific Braden subscales needs to be included in the plan of care.

Financial vulnerability among Medicare managed care enrollees.

Consumer Assessment of Health Plans Survey (CAHPS) data show that Medicare managed care plans often receive low satisfaction scores from certain vulnerable populations. This article describes findings from a qualitative study with beneficiaries about their Medicare managed care experiences. Focus groups were stratified by participant race/ethnicity and self-described health status. Yet participants did not describe their concerns in terms of their race, ethnicity, or health condition, but rather their access to financial resources. Our findings suggest that researchers consider how socioeconomics creates health care vulnerability for racial and ethnic minorities, females, people with disabilities, and other economically marginalized persons.