ABSTRACT
The study involved 97 patients with severe diabetic foot syndrome (DFS) subcompensated type 2 diabetes. All patients were available mediacalcification foot and lower leg arteries of different severity. Depending on the treatment, all patients were divided into 2 groups by stratified randomization. The Ð group received standard therapy, which is indicated for the DFS. A ÐÐ group of patients additionally received basic therapy drug Cytoflavin 10 ml 0,9% NaCl 200 ml for 10 days, followed by transfer to tablet form Cytoflavin 2 tablets 2 times per day orally for one month. We noted a positive trend of treatment of patients who, in addition to standard therapy received the drug Cytoflavin. Thus, the use of complex surgical treatment of patients with mixed form of DFS Cytoflavin reduces the severity of distal polyneuropathy, improves oxygenation of tissues and restores the enzyme activity of antioxidant system, that manifested neuroprotective, antioxidant and anti-hypoxic effects of drugs, which substantiates the indications for its use in the this pathology.
Subject(s)
Antioxidants/therapeutic use , Diabetes Mellitus, Type 2/drug therapy , Diabetic Foot/drug therapy , Flavin Mononucleotide/therapeutic use , Inosine Diphosphate/therapeutic use , Neuroprotective Agents/therapeutic use , Niacinamide/therapeutic use , Succinates/therapeutic use , Combined Modality Therapy , Diabetes Mellitus, Type 2/complications , Diabetic Foot/etiology , Diabetic Foot/surgery , Drug Combinations , Female , Foot/blood supply , Humans , Leg/blood supply , Male , Monckeberg Medial Calcific Sclerosis/complications , Monckeberg Medial Calcific Sclerosis/drug therapyABSTRACT
The objective of the research was to study the effectiveness of the drug Cytoflavin in the comprehensive treatment of mixed form diabetic foot syndrome with media calcification arteries in 75 elderly patients with type 2 diabetes. Depending on the regimen, patients were divided into two groups: control received basic therapy; main group in addition to the base, received the drug Cytoflavin 10 ml 0,9 % NaCl 200 ml for 10 days, followed by a transition to the tablet form of the drug - 2 tablets 2 times per day orally for one month. The inclusion of the drug Cytoflavin in the treatment regimen increased the effectiveness of treatment, which was shown to improve tissue oxygenation due to the normalization of the basal oxygen tension, restoring the activity of antioxidant enzymes and, consequently, in an authentic decrease in the average time of hospital treatment and a decrease in the number of repeated surgical interventions and reamputatsy over the next year.
