ABSTRACT
A method for evaluating the serum leukocyte-modulating activity (LMA) in patients with unstable angina pectoris (UAP) and acute myocardial infarction (AMI) is proposed. The method consists in measuring the total phlogogenic potential of the blood serum from increase or decrease in the chemiluminescence of donor leukocyte suspension after its incubation with patient's serum. LMA sufficiently accurately reflects the imbalance between the pro- and anti-inflammatory activities of the serum in patients with UAP and AMI. Predominance of the stimulating components in the serum predicts a more acute course and rapid development of AMI with complications. Inhibition of the leukocyte activity by patient's serum predicts a torpid protracted course of the acute coronary syndrome, indicative of an extremely low phlogogenic potential of the serum. The course of the acute coronary syndrome is complicated in both cases, requiring additional correction with anti-inflammatory drugs.
