ABSTRACT
The reactogenic and areactogenic properties of a live combined mumps-measles vaccine (MMV) prepared in primary cultures of Japanese quail embryo cells from attenuated strains of mumps (L-3) and measles (L-16) viruses were under study. The observations involved 648 infants varying in ages from 1 to 3 years, seronegative to measles and mumps viruses, without the history of the disease and vaccinations against these infections or contraindications to vaccinations. The infants were vaccinated with 5 batches of MMV with different portions of the mumps and measles components. The vaccinees and controls (placebo injections) were observed for 30 days postvaccination. The live MMV was shown to be a safe, well tolerated preparation with low reactogenicity and a high antigenic activity.
Subject(s)
Measles Vaccine/immunology , Mumps Vaccine/immunology , Antibodies, Viral/analysis , Child, Preschool , Dose-Response Relationship, Immunologic , Drug Combinations , Drug Evaluation , Humans , Infant , Measles Vaccine/adverse effects , Measles virus/immunology , Mumps Vaccine/adverse effects , Mumps virus/immunology , Time FactorsABSTRACT
The data of the study on optimal conditions for the use of a mineral sorbent, bentonite, for isolation of hepatitis A virus and enteroviruses from water bodies are presented.
