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1.
Cureus ; 15(5): e38543, 2023 May.
Article in English | MEDLINE | ID: mdl-37273348

ABSTRACT

BACKGROUND: Early diagnosis of atherosclerosis is exigent in patients with known cardiovascular disease (CVD) risk factors. During the initial phases of atherosclerosis, appearance of plaques can be detected by the ultrasonic phased tracking method which measures the arterial wall elasticity. However, reliable and easily available biochemical markers are not evaluated in the diagnosis of early-stage atherosclerosis. So the current study was carried out to assess the serum cystatin C level as an atherosclerotic marker, by evaluating its association with carotid arterial elastic modulus using the phased tracking method. MATERIALS AND METHODS: A cross-sectional study was conducted on 115 patients having risk factors for atherosclerosis but not meeting carotid intima-media thickness (IMT) criteria. The early-stage atherosclerosis was detected by using the ultrasonic phased tracking method and the patients were divided based on low and high carotid elastic modulus. Serum levels of cystatin-C were measured in association with IMT, and elastic modulus was calculated using a novel method. This study also put forth the evaluation of the sensitivity and specificity of cystatin C for early diagnosis of atherosclerosis. RESULTS: Cystatin C was strongly related to carotid elasticity (r=0.650). Based on multi-linear regression analysis, cystatin C showed significant association with carotid elasticity (ß=0.509; p<0.001). It also displayed significant positive association with high carotid elastic modulus (ß=0.511; p=0.02). Cystatin C showed a sensitivity of 85% in the prediction of high carotid elastic modulus. CONCLUSION: For patients who are at risk to evolve atherosclerosis but are not evident with arterial plaques, cystatin C exhibits a significant association with carotid wall elastic modulus, which eases the detection of atherosclerosis. Thus, cystatin C is a potential biochemical marker for early diagnosis of atherosclerosis.

2.
J Assoc Physicians India ; 68(7): 74-76, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32602686

ABSTRACT

Amyloidosis is a conglomeration of diseases due to production and deposition of amyloid, a proteinaceous substance, into organs, tissues, nerves and other places in the body affecting their normal function. This case report is of a 65 year old gentleman, resident of Bihar admitted with a short history of two months. He came with chief complaints of swelling in both lower limbs associated with heaviness in legs, shortness of breath, dizziness, fatigue and passage of frothy urine for two months. He was investigated and found to have proteinuria, low voltage ECG, Echocardiography showed left ventricular hypertrophy, diastolic dysfunction, mitral regurgitation. Cardiac MRI showed dilated cardiomyopathy due to amyloidosis.


Subject(s)
Amyloidosis , Cardiomyopathies , Aged , Echocardiography , Humans , Hypertrophy, Left Ventricular , Magnetic Resonance Imaging , Male
4.
J Mater Sci Mater Med ; 18(5): 895-8, 2007 May.
Article in English | MEDLINE | ID: mdl-17211722

ABSTRACT

Hydroxyapatite crystals were grown by hydrothermal method using dicalcium phosphate dihydrate crystals as a starting material. The grown crystals were found to be free from carbonate inclusion. Two distinct morphologies were obtained by following two different growth methods. Controlled slow growth process and rapid growth process results in hexagonal and whisker like morphologies.


Subject(s)
Biocompatible Materials/chemistry , Durapatite/chemistry , Crystallization , Crystallography, X-Ray , Hot Temperature , Materials Testing , Microscopy, Electron, Scanning , Spectroscopy, Fourier Transform Infrared
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