[Determinants of low birth weight among newborns to HIV-infected mothers not eligible for antiretroviral treatment in Africa]. / Déterminants du faible poids de naissance chez des enfants nés de mères séropositives pour le VIH, non éligibles au traitement antirétroviral, en Afrique.

BACKGROUND: Low birth weight (LBW) increases the risk of infant death, but little is known about its rate and determinants among babies born to HIV-infected mothers in sub-Saharan Africa. METHODS: This study was conducted in South Africa, Burkina Faso, Uganda and Zambia, during the recruitment process of the PROMISE-PEP (ANRS 12174) clinical trial. The study sample included 1196 subjects screened between August 2009 and December 2011, respectively 254 in South Africa, 221 in Burkina Faso, 197 in Uganda and 524 in Zambia, all ineligible for antiretroviral therapy. Data were collected during ANRS12174 clinical trial antenatal and postnatal screening visits, and during an inclusion visit for completion of an electronic case report form (eCRF). RESULTS: The mean (±SD) age of mothers was 27±5years and their mean CD4 count was 576±195cells/µL. Most mothers lived in a couple (78.7%), had no employment (72.3%) and had a good level of education (74% had gone to school). Male newborns predominated (51.7%). The mean birth weight was 3043g±435g, and 7.8% ([95%CI: 6.3%-9.3%]) of newborns weighed less than 2500g. In univariate analyses, being married or cohabiting, body mass index, WHO HIV disease stage II, female newborn and low gestational age were associated with risk of LBW. In multivariate regression model, low gestational age (aOR=3.74, P<0.0001) and female newborn (aOR=1.63, P=0.04) were significantly associated with LBW. CONCLUSION: The risk factors for LBW found in HIV-infected women ineligible for antiretroviral therapy were the same as in the general population. There was no evidence of additional risk factors associated with HIV infection.

[Tuberculosis in children infected with HIV followed at Charles de Gaulle pediatric university hospital of Ouagadougou (Burkina Faso)]. / Tuberculose Chez Les Enfants Infectes Par Le Vih Suivis Au Chu Pediatrique Charles De Gaulle De Ouagadougou (Burkina Faso).

AIMS: To study the epidemiological aspects, diagnosis and outcome of tuberculosis in children infected with HIV at the University Hospital Pediatric Charles de Gaulle, Ouagadougou. MATERIAL AND METHODS: We conducted a retrospective chart review of children under 15 years followed from 2002 to 2008 for HIV infection. RESULTS: The incidence of tuberculosis was 5.5%. The average patient age was 5 years with a female predominance of 63.6%. Prolonged fever, chronic cough and weight loss were the main reasons for consultation. Pulmonary tuberculosis was the most frequent clinical form with 11 cases. The contribution of the direct smear was low: 13.6%. At the radiological images of miliary (36.4%) were the most frequently encountered followed by non-parenchymal opacities systematized (31.8%). The lethality of co-infection TB-HIV was 18.2%. The prognostic factors were younger age, severe immunosuppression and orphan status or total mother. CONCLUSION: Early detection of HIV infection in children and the capacity of TB diagnosis should improve the management of co-infection in a pediatric setting.