Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life.

Head and neck cancer (H&NC) is a diverse category of tumors related to malignancies in the common aerodigestive pathway, with high metabolic rate, poor nutritional and treatment outcomes, and elevated mortality despite the best standard treatment. Herein, we focus on determining how the phase angle (PA) differs across sex as a predictor of poor prognosis, low quality-of-life (QoL) scores, and mortality in patients with head and neck cancer. This follow-up study presents a sex-differential analysis in a prospective cohort of 139 head and neck cancer patients categorized by sex as male (n = 107) and female (n = 32). Patients were compared in terms of nutritional, biochemical, and quality-of-life indicators between low and normal PA in women (<3.9° (n = 14, 43.75%) and ≥3.9°) and men (<4.5° (n = 62, 57.9%) and ≥4.5°). Our results show that most patients were in locally advanced clinical stages (women: n = 21 (65.7%); men: n = 67 (62.6%)) and that patients with low PA had a lower punctuation in parameters such as handgrip strength, four-meter walking speed, albumin, C-reactive protein (CRP), and CRP/albumin ratio (CAR), as well as the worst QoL scores in functional and symptomatic scales in both the male and female groups. A comparison between sexes revealed significant disparities; malnourishment and tumor cachexia related to an inflammatory state was more evident in the women's group.

Phase Angle and Nutritional Status: The Impact on Survival and Health-Related Quality of Life in Locally Advanced Uterine Cervical Cancer.

The phase angle, an indicator of muscle mass status and membrane cell integrity, has been associated with low survival, poorer clinical outcomes, and worse quality of life among cancer patients, but information on women with uterine cervical cancer (UCCa) is scarce. In this prospective study, we used a bioelectrical impedance analyzer to obtain the PA of 65 women with UCCa. We compared the health-related quality of life and inflammatory and nutritional indicators between low PA and normal PA. The mean age was 52 ± 13. The low PA and normal PA groups differed in terms of the C-reactive protein (15.8 ± 19.6 versus 6.82 ± 5.02, p = 0.022), glucose (125.39 ± 88.19 versus 88.78 ± 23.08, p = 0.021), albumin (3.9 ± 0.39 versus 4.37 ± 0.30, p = 0.000), EORTC QLQ-C30 loss of appetite symptom scale score (33.33 (0.0-100.00) versus 0.0 (0.0-0.0), p = 0.005), and EORTC QLQ-CX24 menopausal symptoms scale score (0.0 (0.0-33.33) versus 0.0 (0.0-100.0), p = 0.03). The main finding of the present study is the interaction between PA and obesity as critical cofactors in the UCCa adeno and adenosquamous histologic variants, to a greater extent than cervical squamous cell carcinoma.

Phase Angle, a Cornerstone of Outcome in Head and Neck Cancer.

In patients with head and neck cancer, malnutrition is common. Most cases are treated by chemo-radiotherapy and surgery, with adverse effects on the aerodigestive area. Clinical and biochemical characteristics, health-related quality of life, survival, and risk of death were studied. The selected subjects were divided into normal- and low-phase-angle (PA) groups and followed up for at least two years. Mean ages were 67.2 and 59.3 years for low and normal PA, respectively. Patients with PA < 4.42° had significant differences in age, anthropometric and biochemical indicators of malnutrition, and inflammatory status compared to patients with PA > 4.42°. Statistical differences were found in the functional and symptom scales, with lower functional scores and higher symptom scores in patients with low PA. Median survival was 19.8 months for those with PA < 4.42° versus 34.4 months for those with PA > 4.42° (p < 0.001).The relative risk of death was related to low PA (2.6; p < 0.001). The percentage of living patients (41.7%) is almost the same as the percentage of deceased subjects (43.1%; p = 0.002), with high death rates in patients with PA < 4.42°. Phase angle was the most crucial predictor of survival and a risk factor for death in the studied cases.

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old.

Insulin levels, adipocytokines, and inflammatory mediators trigger benign breast disease (BBD) and breast cancer (BC). The relationship between serum adipocytokines levels, overweight-obesity, metabolic disturbs, and BC is unclear. Methods: To analyze the serum levels of the adipocytokines, insulin, and the HOMA IR in women without breast disease, with BBD or BC, and the role of these as risk factors for benign breast disease or breast cancer. Results: Adipsin values > 0.91 and visfatin levels > 1.18 ng/mL represent a risk factor to develop BBD in NBD lean women (OR = 18; and OR = 12). Data in overweight-obese women groups confirm the observation due to insulin levels > 2.6 mU/mL and HOMA IR > 0.78, with OR = 60.2 and 18, respectively; adipsin OR = 26.4, visfatin OR = 12. Breast cancer risk showed a similar behavior: Adipsin risk, adjusted by insulin and visfatin OR = 56 or HOMA IR and visfatin OR = 22.7. Conclusion: Adipose tissue is crucial for premalignant and malignant tissue transformation in women with overweight-obesity. The adipocyte−breast epithelium interaction could trigger a malignant transformation in a continuum, starting with BBD as premalignant disease, especially in overweight-obese women.

Effect of mechanical cleaning protocols in the fiber post space on the adhesive interface between universal adhesive and root dentin.

The aim of this study was to evaluate the effects of cleaning protocols on the presence of residues, open dentinal tubules, and bond strength of a self-etch adhesive plus a dual-cure resin cement to dentin in the fiber-post space. The methods for cleaning utilized were conventional irrigation (CI), rotary brush with continuous rotary movement (RB), and continuous ultrasonic irrigation (CUI). Sixty bovine incisors were used for fiber-post space preparation. Thirty roots were divided into three groups (n = 10) according to the cleaning protocols and submitted to scanning electron microscope to evaluate presence of residues and relative quantity of open dentinal tubules on dentin surface. Similar protocols were performed in the other thirty roots (n = 10) using a self-etching adhesive system (Scotchbond Universal) and a dual-cure resin cement (Relyx Unicem 2). After 6 months cervical, middle, and apical thirds sections of fiber-post space were submitted to push-out testing. To data ANOVA and Tukey's test were employed (α = 5%). RB and CUI showed the lowest presence of residues on dentin surface (p = .015) and the highest bond strength values (p < .001), regardless of the dentin third. CUI presented the highest quantity of open dentinal tubules in middle and apical thirds (p < .001). CI presented the lowest bond strength value of resin cement, regardless of dentin third (p < .001). Mechanical cleaning protocols, such as RB and CUI, presented better surface cleaning capabilities and higher bond strength than CI with dual-cure resin cement employed. The use of a mechanical cleaning protocol seems to cause appropriate condition on the root dentin surface. Mechanical cleaning of root dentin provided greater bond strength of the self-etching system with dual resin cement. Conventional irrigation did not provide adequate root dentin cleaning. RESEARCH HIGHLIGHTS: • The use of a mechanical cleaning protocol seems to cause appropriate condition on the root dentin surface. • Mechanical cleaning of root dentin provided greater bond strength of the self-etching system with dual resin cement. • Conventional irrigation did not provide adequate root dentin cleaning.

Functional MRI findings in personality disorders: A review.

Personality disorders (PDs) have a prevalence of approximately 10% in the United States, translating to over 30 million people affected in just one country. The true prevalence of these disorders may be even higher, as the paucity of objective diagnostic criteria could be leading to underdiagnosis. Because little is known about the underlying neuropathologies of these disorders, patients are diagnosed using subjective criteria and treated nonspecifically. To better understand the neural aberrancies responsible for these patients' symptoms, a review of functional MRI literature was performed. The findings reveal that each PD is characterized by a unique set of activation changes corresponding to individual structures or specific neural networks. While unique patterns of neural activity are distinguishable within each PD, aberrations of the limbic/paralimbic structures and default mode network are noted across several of them. In addition to identifying valuable activation patterns, this review reveals a void in research pertaining to paranoid, schizoid, histrionic, narcissistic, and dependent PDs. By delineating patterns in PD neuropathology, we can more effectively direct future research efforts toward enhancing objective diagnostic techniques and developing targeted treatment modalities. Furthermore, understanding why patients are manifesting certain symptoms can advance clinical awareness and improve patient outcomes.

Frequency and phenotype of headache in covid-19: a study of 2194 patients.

To estimate the frequency of headache in patients with confirmed COVID-19 and characterize the phenotype of headache attributed to COVID-19, comparing patients depending on the need of hospitalization and sex, an observational study was done. We systematically screened all eligible patients from a reference population of 261,431 between March 8 (first case) and April 11, 2020. A physician administered a survey assessing demographic and clinical data and the phenotype of the headache. During the study period, 2194 patients out of the population at risk were diagnosed with COVID-19. Headache was described by 514/2194 patients (23.4%, 95% CI 21.7-25.3%), including 383/1614 (23.7%) outpatients and 131/580 (22.6%) inpatients. The headache phenotype was studied in detail in 458 patients (mean age, 51 years; 72% female; prior history of headache, 49%). Headache was the most frequent first symptom of COVID-19. Median headache onset was within 24 h, median duration was 7 days and persisted after 1 month in 13% of patients. Pain was bilateral (80%), predominantly frontal (71%), with pressing quality (75%), of severe intensity. Systemic symptoms were present in 98% of patients. Headache frequency and phenotype was similar in patients with and without need for hospitalization and when comparing male and female patients, being more intense in females.Trial registration: This study was supported by the Institute of Health Carlos III (ISCIII), code 07.04.467804.74011 and Regional Health Administration, Gerencia Regional de Salud, Castilla y Leon (GRS: 2289/A/2020).

Cementerios y cadáveres durante las crisis epidémicas en Guadalajara, Jalisco. México / Cemeteries and bodies in epidemic crisis in Guadalajara, Jalisco. México

Resumen Objetivo: Describir las características de los cementerios y el tratamiento higiénico de cadáveres durante las pandemias a través de la historia. Materiales y método: Es un estudio histórico que parte de la heurística y se combina con el criticismo para evaluar las fuentes utilizadas y responder al objetivo. El universo de trabajo se construyó con documentos del Archivo Histórico Municipal de Guadalajara sobre los panteones de esta ciudad y la revisión bibliográfica en bibliotecas y medios electrónicos relacionados con el tema. Resultados: Las inhumaciones estuvieron a cargo de la iglesia al principio, por razones médico-sanitarias, se trasladaron a orillas de las ciudades en el siglo XIX, y durante el siglo XX se construyeron otros más, quedando algunos dentro de la zona urbana. En 1785-1786, dejaban los cadáveres desnudos y amontonados a las puertas de las iglesias. Se pedía dejarlos en puntos específicos debido a su riesgo para la salud pública. Los cadáveres eran trasladados en cajas de madera cerradas para evitar más contagios. Actualmente, durante la pandemia en México, cada estado ha tomado estrategias para el control de contagios. El gobierno de Jalisco ha conformado la Comisión Interinstitucional de Manejo de Cadáveres por COVID-19, y la aplicación de normas de bioseguridad tanto en hospitales como fuera de ellos. Conclusiones: La evolución de los panteones de Guadalajara, ha dependido de asuntos sociales y de salud, vinculado a intereses económicos, políticos y religiosos. A pesar de las normas establecidas, los panteones han quedado dentro de la zona urbana en consecuencia al crecimiento poblacional, su ubicación geográfica representa una situación crítica, de ahí la importancia del control sanitario y normas de bioseguridad en el manejo de cadáveres.

Abstract Objective. To describe the characteristics of cemeteries and the hygienic treatment of corpses during pandemics throughout history. Materials and method. It is a historical study that starts from Heuristics and it is combined with Criticism to evaluate the sources used and respond to the objective. The universe of work was done with documents from the Guadalajara Municipal Historical Archive on the pantheons of this city and the bibliographic review in libraries and electronic media related to the subject. Results The burials were in charge of the church at first, for medical-sanitary reasons, they moved to the cities' borders in the 19th century, and during the 20th century others were built, some remained within the urban area.1785-1786 The bodies were left naked and piled up at the churches doors. They were asked to leave them at specific points due to their risk to public health. The bodies were transported in closed wooden boxes to avoid further contagion. Currently, during the pandemic in Mexico, each state has adopted strategies for contagion control. Jalisco's government has formed the Inter- institutional Commission for the Management of Dead Bodies by COVID-19, and the application of biosafety regulations both in and outside hospitals. Conclusions. The evolution of the pantheons of Guadalajara has depended on social and health issues, linked to economic, political and religious interests. Despite the established norms, the pantheons have remained within the urban area due to population growth, their geographical location represents a critical situation, hence the importance of sanitary control and biosafety standards in the management of corpses.

Physicochemical Properties of a Bioceramic Repair Material - BioMTA.

This study aimed to assess the physicochemical properties of a repair material in the Brazilian market, BioMTA, in comparison to other two materials currently in use (Biodentine and MTA Angelus). The initial setting time was evaluated using Gillmore needle. The pH was measured with a pH-meter after 24 h, 3, 7, 14 and 21 days. The radiopacity was determined using the equivalence in millimeters of aluminum (mm Al) from digitized occlusal radiographs. Solubility was determined after immersion in water for 7 days. The data were analyzed by one-way ANOVA and Tukey tests (a=0.05). The BioMTA initial setting time (5.2 min) was lower than the other materials (p<0.05). All materials showed an alkaline pH at 21 days. At 24 h, BioMTA was the most alkaline material (p<0.05); and at 3, 7, 14 and 21 days there was no difference between BioMTA and Biodentine (p>0.05), both being more alkaline than MTA Angelus (p<0.05). The radiopacity of BioMTA (4.2 mm Al) was significantly higher compared to Biodentine (p<0.05) and lower than MTA Angelus (p<0.05). The solubility of the materials was -4.2%, -1.6% and 4.1% for BioMTA, MTA Angelus and Biodentine, respectively, with a significant difference between them (p<0.05). Therefore, it can be concluded that BioMTA displayed a shorter setting time, an alkaline pH, a higher radiopacity, and a gain in mass.

Physicochemical properties of a bioceramic repair material - biomta

Abstract This study aimed to assess the physicochemical properties of a repair material in the Brazilian market, BioMTA, in comparison to other two materials currently in use (Biodentine and MTA Angelus). The initial setting time was evaluated using Gillmore needle. The pH was measured with a pH-meter after 24 h, 3, 7, 14 and 21 days. The radiopacity was determined using the equivalence in millimeters of aluminum (mm Al) from digitized occlusal radiographs. Solubility was determined after immersion in water for 7 days. The data were analyzed by one-way ANOVA and Tukey tests (a=0.05). The BioMTA initial setting time (5.2 min) was lower than the other materials (p<0.05). All materials showed an alkaline pH at 21 days. At 24 h, BioMTA was the most alkaline material (p<0.05); and at 3, 7, 14 and 21 days there was no difference between BioMTA and Biodentine (p>0.05), both being more alkaline than MTA Angelus (p<0.05). The radiopacity of BioMTA (4.2 mm Al) was significantly higher compared to Biodentine (p<0.05) and lower than MTA Angelus (p<0.05). The solubility of the materials was -4.2%, -1.6% and 4.1% for BioMTA, MTA Angelus and Biodentine, respectively, with a significant difference between them (p<0.05). Therefore, it can be concluded that BioMTA displayed a shorter setting time, an alkaline pH, a higher radiopacity, and a gain in mass.

Resumo Este estudo teve como objetivo avaliar as propriedades físico-químicas de um material reparador disponível no mercado brasileiro, BioMTA, em comparação com outros dois materiais atualmente em uso (Biodentine e MTA Angelus). O tempo de presa inicial foi avaliado usando a agulha de Gillmore. O pH foi medido com um pH-metro após 24 h, 3, 7, 14 e 21 dias. A radiopacidade foi determinada aplicando a equivalência em milímetros de alumínio (mm Al) de radiografias oclusais digitalizadas. A solubilidade foi determinada após imersão em água por 7 dias. Os dados foram analisados ​​por meio dos testes ANOVA de uma via e Tukey (a=0,05). O tempo de presa inicial do BioMTA (5,2 min) foi menor do que os outros materiais (p<0,05). Todos os materiais apresentaram pH alcalino aos 21 dias. Às 24 h, o BioMTA foi o material mais alcalino (p<0,05); e aos 3, 7, 14 e 21 dias não houve diferença entre BioMTA e Biodentine (p>0,05), sendo ambos mais alcalinos que MTA Angelus (p<0,05). A radiopacidade do BioMTA (4,2 mm Al) foi significativamente maior em comparação ao Biodentine (p<0,05) e menor que o MTA Angelus (p<0,05). A solubilidade dos materiais foi de -4,2%, -1,6% e 4,1% para BioMTA, MTA Angelus e Biodentine, respectivamente, havendo diferença significativa entre eles (p<0,05). Portanto, pode-se concluir que o BioMTA apresentou um menor tempo de presa, pH alcalino, uma alta radiopacidade e um ganho em massa.

Tratamento endodôntico de canino superior birradicular: relato de caso / Endodontic treatment of birradicular maxillary canine: case report

O presente artigo descreve um caso incomum de canino superior direito com duas raízes. Esse é o quarto caso relatado na literatura. Paciente do sexo feminino, 66 anos de idade, foi encaminhada para tratamento endodôntico do dente #13. A avaliação clínica mostrou que o dente #13 não apresentava resposta após o teste de vitalidade. Radiografias foram realizadas e revelaram que o dente #13 apresentava duas raízes. Em seguida, a paciente foi submetida a tratamento endodôntico. Esse relato de caso é relevante porque descreve uma variação anatômica rara, mas que pode se apresentar na clínica. Por tal motivo, o dentista precisa ter domínio da anatomia normal dos dentes para realizar corretamente o tratamento endodôntico, assim como conhecer as possíveis variações anatômicas, e analisar minuciosamente a radiografia de diagnóstico para ter uma noção individualizada da anatomia do dente a tratar (AU).

This paper describes an unusual case of right maxillary canine with two roots. This is the fourth finding that has been reported in the literature. A 66-year-old female patient was referred to endodontic treatment in the tooth #13. Clinical evaluation showed that tooth #13 presented no response after the vitality test. Radiographs were taken and revealed that the tooth #13 presented two roots. Then, the patient was submitted to endodontic treatment. This case report is relevant because it describes an atypical anatomical variation, but with possible occurrence in endodontic clinical. For this reason, the dentist needs to have knowledge of the normal anatomy of the teeth to correctly perform the endodontic treatment, as well as to know the possible anatomical variations, and to thoroughly analyze the diagnostic radiography to have an individualized notion of the anatomy of the tooth to be treated (AU).

Imaging of Spine Fractures With Emphasis on the Craniocervical Junction.

Spinal cord injury often times is a catastrophic result of trauma. Delay in diagnosis may result in increased morbidity and mortality. Cross-sectional imaging is now increasingly used as a first-line diagnostic modality in the setting of trauma for recognition of spine fractures and ligamentous injuries that might be missed on routine radiographs. The learning objectives of this article are to review the anatomy of the spine and understand the mechanisms of injury in the cervical, thoracic, and lumbosacral column by applying easy and reproducible classification systems to guide clinical management.

Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology.

BACKGROUND: We systematically analyzed the extent of disease in unifocal invasive lobular carcinoma (ILC) using ultrasonography, with the histopathologic findings as the reference standard. PATIENTS AND METHODS: In the present single-institution retrospective study, 128 cases of ILC were identified during a 5-year period. After exclusions, the analyzed cohort included 66 cases. Ultrasound measurements of the tumor extent along 3 axes were obtained. The tumor size was determined as the largest extent among the 3 axes and the tumor volume by ellipsoidal approximation. Pathology review provided the tumor size and volume. Correlation and regression analyses of tumor size and volume from the ultrasound and pathologic examinations were performed. The tumor stage from the ultrasound and pathologic examinations were used for the concordance analyses. RESULTS: The median and quartiles (Q1, Q3) of tumor size from ultrasonography and pathology were 12.5 mm (Q1, 9 mm; Q3, 19 mm) and 17 mm (Q1, 12 mm; Q3, 25 mm), respectively. The corresponding data for tumor volume were 0.52 cm3 (Q1, 0.18 cm3; Q3, 1.92 cm3) and 1.04 cm3 (Q1, 0.45 cm3; Q3, 2.49 cm3). The ultrasound measurements correlated with the pathology-reported tumor size (Spearman ρ = 0.678; P < .0001) and volume (Spearman ρ = 0.699; P < .0001). The ultrasound-measured size and volume differed from the pathology-reported size and volume (P < .0001; Wilcoxon signed ranks test). Concordance between the clinical tumor size stage from ultrasound (cT) and pathology tumor size stage (pT) varied with the pT stage (P = .0003, Fisher's exact test), with the greatest concordance rate of 95.7% (95% confidence limit, 85.2%-99.5%) observed for pT1 tumors. CONCLUSION: Ultrasonography underestimates the tumor size and volume, with the underestimation increasing for larger tumors. Hence, the concordance rate in tumor size stage between ultrasonography and pathology is tumor size dependent, with the greatest concordance rate observed for pT1 tumors.

Evaluation of dentin desensitization protocols on the dentinal surface and their effects on the dentin bond interface.

OBJECTIVES: To evaluate the effect of desensitizing agent containing calcium phosphate nanoparticles on the bond strength of etch-and-rinse adhesive system (Scotchbond Multi-Purpose), presence of precipitate, dentinal tubule obliteration and hybrid layer formation in dentin in comparison with potassium nitrate plus sodium fluoride or strontium chloride compounds. METHODS: 150 bovine incisors were treated with (n = 10): G1, Desensibilize Nano P (Ca3(PO4)2+5%KNO3+0.9%NaF); G2, Desensibilize (10%SrCl2+5%KNO3); G3, Desensibilize KF2% (5%KNO3+0.2%NaF); G4, Ultra EZ (3%KNO3+0.25%NaF) and G5, no treated (control). Scanning electron microscopy was used to assess the incidence of precipitates (500×) and obliterated dentinal tubule counts (1.000×). The adhesive system was used after all desensitization treatments. The bond strength (n = 40) and the fracture pattern were evaluated. Confocal laser microscopy was used to quantify the hybrid layer formation in dentin. RESULTS: G1 and G2 presented higher adhesive system bond strength (MPa) than G4 and G5, however no significant differences were observed in comparison with G3. Cohesive fracture was frequently found: G1 (58.5%), G2 (51.3%) and G3 (43.8%). G1 showed the highest incidence of precipitates and the highest number of blocked dentinal tubules. G1 and G2 presented similar hybrid layer formation and the highest hybrid layer formation values. CONCLUSIONS: Desensibilize Nano P (G1) favored the bond strength of the adhesive system to dentin, increased the precipitation of residues, obliteration of dentinal tubules, and hybrid layer formation in comparison with other agents. CLINICAL RELEVANCE: Desensitizers promote dentin obliteration, however, may affect dentin bonding.

Effects of different peracetic acid formulations on post space radicular dentin.

STATEMENT OF PROBLEM: The optimal irrigating solution with antimicrobial and dentin cleansing properties for post space preparation for fiber posts is unclear. Peracetic acid is one option but is available in various chemical formulations that require evaluation. PURPOSE: The purpose of this in vitro study was to evaluate dentin surface cleanliness based on the presence of a smear layer and the number of open dentin tubules. It also investigates the chemical composition of residues after canal irrigation with a 1% peracetic acid solution (PA) at low or high concentration of hydrogen peroxide during the preparation of intracanal fiber posts. MATERIAL AND METHODS: After filling the root canals of 40 mandibular incisors, a rotary instrument was used for intracanal preparation to place fiber posts. The teeth were divided into 4 groups (n=10) according to the post space irrigation protocol as follows: CG (control): distilled water; NA (NaOCl): 2.5% sodium hypochlorite; LH: PA with low concentration of hydrogen peroxide; and HH: PA with high concentrations of hydrogen peroxide. After irrigation, the teeth were sectioned, and the intracanal dentin surface was subjected to analysis using energy dispersive spectroscopy to evaluate chemical composition and to scanning electron microscopy (×500) to evaluate the presence of the smear layer. The number of open dentin tubules was measured by scanning electron microscopy analysis (×2000) using photo-editing software. ANOVA and the Tukey test (α=.05) were used to evaluate the data, except for the presence of a smear layer, for which the Kruskal-Wallis and Dunn tests were used (α=.05). RESULTS: The highest concentrations of oxygen in the dentin residues were detected in LH and HH (P<.05); CG and NA showed similar oxygen concentrations (P>.05). NA had a higher concentration of chlorine (P<.05), whereas LH had a lower amount of smear layer and a larger number of open dentin tubules than the other groups (P<.05). These were equivalent to each other (P>.05), except for HH, which also had a larger number of open dentin tubules than CG and NA (P<.05). CONCLUSIONS: PA 1% with a low concentration of hydrogen peroxide yielded a lower amount of smear layer and a larger number of open dentin tubules in the dentin of the post space when compared with PA 1% with a high concentration of hydrogen peroxide, despite maintaining a similar oxygen concentration in these dentin residues.

Factores asociados a accidentes, enfermedades y ausentismo laboral: análisis de una cohorte de trabajadores formales en Chile / Factors associated with accidents, illness and absenteeism: analysis of a cohort of formal workers in Chile

Objetivo: Estimar la asociación entre factores de riesgo y la ocurrencia de enfermedades, accidentes y ausentismo laboral en trabajadores formales. Método: Estudio de cohorte retrospectiva usando dos fuentes de información: registro de evaluaciones ocupacionales preventivas y de episodios de accidentes y enfermedades laborales (2009-2012). Se realizó un análisis descriptivo de variables de salud y de factores de riesgo. Regresiones logísticas para la ocurrencia de enfermedades y accidentes. Se usó una regresión Poisson-cero-inflado para el ausentismo laboral. Resultados: los > 60 años tienen un exceso de riesgo de enfermedad laboral (OR-ajustada 19,18 respecto a < 30 años) y los sedentarios una OR-ajustada 1,75. Los < 30 años tienen una OR-ajustada de 1,38, los que tienen circunferencia de cintura (CC) superior a la recomendada una OR-ajustada de 1,31 y los sedentarios 1,23 para la probabilidad de accidentes de trabajo. Las mujeres tienen una OR-ajustada 1,99 y CC-superior 1,29 para la probabilidad de accidente de trayecto. Ser mujer (IRR 1,45), tener > 60 años (IRR 2,69), trabajar en actividades inmobiliarias (IRR 2,37) y en explotación de minas (IRR 2,38), tienen una probabilidad mayor de más días de ausentismo. Conclusiones: Factores no modificables (sexo y edad), junto con factores modificables, como el sedentarismo y el estado nutricional, contribuyen a eventos laborales no deseados.

Objective: To determine the association among lifestyle-related risk factors and the occurrence of occupational diseases, accidents and absenteeism in a cohort of formal workers. Method: A retrospective cohort study was carried out by using two information sources: a registry of preventive occupational evaluations and another registry of episodes of occupational accidents and diseases (2009-2012). A descriptive analysis was performed of health variables and risk factors. Logistic regressions were used to calculate the likelihood of occupational accidents and diseases and a zero-inflated Poisson regression was used to model occupational absenteeism. Results: A total of 47.221 workers were included, of which 86,3% were men. The mean follow-up was 1,96 years. Workers aged >60 years had an excess risk of occupational diseases, with an OR of 19.18 compared with workers aged <30 years, while sedentary workers had an OR of 1,75. The likelihood of occupational accidents was higher in workers younger than 30 years (OR 1,38), those with a waist circumference (WC) higher than recommended (OR 1,31) and those who were sedentary (OR 1,23). Women had an OR of 1.99 and those with a WC higher than recommended had an OR of 1,29 for the likelihood of a commuting accident to and from work. Female sex (IRR 1,45), age >60 years (IRR 2,69), and working in the property sector (IRR 2,37) and in mining (IRR 2,38) conferred a higher probability of absenteeism. Conclusions: Unmodifiable factors (age and sex), as well as modifiable factors, such as sedentariness and nutritional status, contribute to undesired occupational events.

[Access to social networks and health care among extremely poor people]. / Acceso a redes sociales y de salud de población en extrema pobreza.

BACKGROUND: Extremely poor people have more problems to have access to social networks and health care. AIM: To evaluate the access to health services and the perception about these services of adults living in conditions of extreme poverty. MATERIAL AND METHODS: A survey was applied to 361 people living in slums aged 15 to 77 years (83% females), that were living in these conditions for a mean of 11 years. Twenty six in-depth interviews were also performed to prototypical subjects living in extreme poverty. RESULTS: Ten percent of subjects were illiterate. Sixty two percent were unsatisfied with their access to health services and 32% were not registered in primary health clinics. Among children of less than 6 years of age, 22% were delayed in their vaccination schedule and 32% were not withdrawing the milk delivered by the complementary feeding program of the clinic. The qualitative analysis revealed that the lack of access to health care is associated with the feeling of exclusion, mutual distrust and lack of resolution of health problems. CONCLUSIONS: People living in extreme poverty are distrustful and perceive obstacles to have access to the health care system.

Acceso a redes sociales y de salud de población en extrema pobreza / Access to social networks and health care among extremely poor people

Background: Extremely poor people have more problems to have access to social networks and health care. Aim: To evaluate the access to health services and the perception about these services of adults living in conditions of extreme poverty. Material and methods: A survey was applied to 361 people living in slums aged 15 to 77 years (83 percent females), that were living in these conditions for a mean of 11 years. Twenty six in-depth interviews were also performed to prototypical subjects living in extreme poverty. Results: Ten percent of subjects were illiterate. Sixty two percent were unsatisfied with their access to health services and 32 percent were not registered in primary health clinics. Among children of less than 6 years of age, 22 percent were delayed in their vaccination schedule and 32 percent were not withdrawing the milk delivered by the complementary feeding program of the clinic. The qualitative analysis revealed that the lack of access to health care is associated with the feeling of exclusion, mutual distrust and lack of resolution of health problems. Conclusions: People living in extreme poverty are distrustful and perceive obstacles to have access to the health care system.