ABSTRACT
The objective of this study was to compare the immunoexpression of integrin α5ß1, fibronectin, and the Bcl-2 protein in normal oral mucosa (NOM), inflammatory fibroepithelial hyperplasia (IFH), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC). Eleven cases of NOM, 16 IFH, 20 OED, and 27 OSCC were selected for analysis of the immunoexpression of integrin α5ß1, fibronectin, and bcl-2 protein. There was an association between the intensity and location of the integrin α5ß1 expression, especially in the OSCC, that 48.1% of cases showed weak immunoreactivity and 40.7% in the suprabasal layer (P < 0.05). There was an association between the pattern and distribution of fibronectin expression in basement membrane, where 90% of NOM showed a pattern of linear continuous and 80% of OED exhibited focal distribution (P < 0.05). The fibronectin expression in connective tissue was predominantly intense with an association of staining pattern among the different specimens, where 37% of OSCC showed a reticular pattern (P < 0.05). There was an association of bcl-2 protein among the types of specimens, especially in IFH and OSCC, where 100% of the cases exhibited scores 1 of staining (P < 0.05). Within this context, the interaction of integrin α5ß1 with its main ligand in the extracellular matrix, fibronectin, is suggested to influence the survival of tumor cells and to favor their proliferation by modulating apoptosis through the upregulation of antiapoptotic proteins or the suppression of apoptotic mediators.
Subject(s)
Carcinoma, Squamous Cell/pathology , Fibronectins/metabolism , Hyperplasia/pathology , Integrin alpha5beta1/metabolism , Mouth Mucosa/metabolism , Neoplasms, Fibroepithelial/pathology , Proto-Oncogene Proteins c-bcl-2/metabolism , Adult , Aged , Female , Gene Expression Regulation, Neoplastic , Humans , Immunohistochemistry , Male , Middle AgedABSTRACT
La displasia ectodérmica hereditaria (DEH) representa un grupo de disturbios caracterizados por aplasia o displasia de estructuras y tejidos derivados del ectoderma. Las estructuras generalmente afectadas incluyen el cabello, piel, uñas, dientes y diversas glándulas. Esta condición representa un disturbio raro y se estima su frecuencia de un caso a cada 10.000 o 100.000 nacimientos, teniendo el dentista un papel importante en su diagnóstico debido a las alteraciones dentales que ocurren. Los autores relatan 3 casos de DEH diagnosticados en una misma familia; además se realiza una breve revisión de la literatura sobre esta condición
