ABSTRACT
Rickettsioses are worldwide distributed infectious disease caused by intracellular small Gram-negative bacteria transmitted to humans by the bite of contaminated arthropods, such as ticks. Systemic disease typically consists of a triad of high fever, headache, and skin rash. It usually has a self-limited course, but severe, life-threatening complications can sometimes occur. It may be clinically difficult to differentiate rickettsial diseases from other febrile illnesses. Rickettsial infection has been largely underestimated as a cause of infectious uveitis for long decades in the past. Conversely, recent data show that ocular involvement is much more common than previously thought, with retinitis, retinal vasculitis, and neuroretinitis being the most typical and frequent findings. Early clinical diagnosis of rickettsial disease, while awaiting laboratory test results, is essential for prompt initiation of appropriate antibiotic treatment to prevent systemic and ocular morbidity. The prevention remains the mainstay of rickettsial infection control.
ABSTRACT
AIM: To describe a case of posterior ischemic optic neuropathy (PION) revealing carotid arterial dissection occurring after ipsilateral tooth extraction. CASE REPORT: A 56-year-old patient referred for sudden loss of vision of the left eye (LE) since 3 weeks. Initial visual acuity was 10/10 in the right eye (RE) and limited to light perception in the LE. Ophthalmological examination was without abnormalities in the RE. A relative afferent pupillary defect was noted in the LE. Fundus examination of the LE revealed a papillary pallor, without excavation. Fluorescein angiography revealed no abnormalities in both eyes, including normal choroidal filling. The diagnosis of left PION was retained. A careful questioning of the patient revealed the history of tooth extraction under intra-oral local anesthesia one day before the vision loss. Investigational work up revealed a dissection of the left internal carotid artery. CONCLUSION: Dissection of the internal carotid artery is a rare but possible cause of PION. Ocular involvement may be the only manifestation. Clinicians should be aware of such manifestation especially in case of particular context of micro-trauma, such as dental procedures, and look for an underlying cause that may be potentially fatal.
Subject(s)
Carotid Artery, Internal, Dissection/etiology , Optic Neuropathy, Ischemic/diagnosis , Optic Neuropathy, Ischemic/etiology , Tooth Extraction/adverse effects , Carotid Artery, Internal, Dissection/diagnosis , Diagnosis, Differential , Humans , Male , Middle Aged , Vision Disorders/diagnosis , Vision Disorders/etiology , Visual Acuity/physiologyABSTRACT
PURPOSE: To describe swept source-OCT (SS-OCT) and swept source-OCT angiography (SS-OCTA) findings in eyes with posterior microphthalmos (PM). METHODS: Twelve eyes (six patients) with PM were evaluated using SS-OCT and SS-OCTA. Structural changes, subfoveal choroidal thickness (SFCT), and perifoveal capillary changes with qualitative and quantitative assessments were analyzed. Twenty eyes served as control group. RESULTS: SS-OCT findings included elevated retinal papillo-macular fold (75%), retinal pigment epithelium folds (83%), macular cystoid spaces (42%), subretinal fluid (17%), and increased visibility of posterior vitreous cortex and hyaloid (42%). Mean SFCT in PM and in control eyes were 430.33 ± 157.48 µm and 290.05 ± 52.87 µm, respectively (p = 0.004). Perifoveal capillary changes on SS-OCTA included foveal avascular zone (FAZ) remodeling (100%), vessel tortuosity (67%), disorganization of the deep capillary network (67%), intraretinal cystoid spaces (42%), and areas of signal voids in the choriocapillaris (33%). FAZ area was significantly smaller in eyes with PM than in the control group in both the superficial (p < 0.001) and deep capillary plexuses (p = 0.001). Capillary vessel density (CVD) was significantly lower in the PM than in the control group in the deep capillary plexus (p = 0.004). Log MAR BCVA correlated negatively with axial length (r = - 0.929, p < 0.001), FAZ area in both the superficial (r = - 0.637, p < 0.001) and deep capillary plexus (r = - 0.561, p = 0002), and CVD in the deep capillary plexus (r = - 0.450, p = 0.016). CONCLUSIONS: Combined SS-OCT and SS-OCTA allow the detection of various retinal and choroidal structural and microvascular changes in eyes with PM. These findings can provide new insights onto this blinding ocular condition.
