ABSTRACT
OBJECTIVE: to assess prevalence of acute kidney injury (AKI) among patients with acute decompensated heart failure (ADHF) and its impact on prognosis in a hospitalized patient. MATERIAL AND METHODS: a sample of patients hospitalized with signs of ADHF. RESULTS: Prevalence of AKI in this sample was 23.1%. There was no significant difference between patients with and without AKI by age, gender, and hemodynamic parameters. Portion of subjects with systolic blood pressure below 125 mm Hg among patients with AKI did not exceed one third. Development of AKI was associated with 3-fold elevation of risk of injury of the liver. Hospital mortality in patients with AKI was 7 times higher than in patients without AKI. CONCLUSION: These results resemble those obtained in foreign studies on AKI prevalence among patients with ADHF except hospital mortality which turned out to be twice higher. Acute liver injury highly prevalent among patients with AKI worsened their prognosis. Risk of lethal outcome in patients with ADHF and AKI was inversely related to diastolic blood pressure and directly depended on maximal concentrations of creatinine and aspartate aminotransferase. Management of patients with ADHF should include measures of correction of renal and hepatic dysfunction and as well as use of drugs improving prognosis during hospital stay and in remote period.
