[Causes of development and the role of immunodeficiency in trauma]. / Prichiny vozniknoveniia i rol' immunodefitsita pri travme.

The authors provide evidence for a concept of pathogenetic heterogeneity of posttraumatic immunodeficiency, analyze the causes and mechanisms underlying the development of cellular, combined or humoral immunodeficiency having different (sano-, genetic or pathogenetic) influence) in trauma. Cellular immunodeficiency marked by suppression of cellular effector functions is considered as a sanogenetic factor stimulating reparation processes and protecting from infection via humoral immunity activation. Combined immunodeficiency with suppressed humoral and cellular effector functions forms a pathogenetic basis for infectious complications of trauma. Humoral immunodeficiency marked by suppression of humoral effector functions and activation of cellular effector functions underlies inhibition of reparation processes and autodermograft lysis after autoplasty.