ABSTRACT
BACKGROUND: Darier-Ferrand dermatofibrosarcoma (DFS) is a rare malignant cutaneous neoplasm characterized by local aggressiveness, high risk of recurrence, and low metastatic potential. CASE PRESENTATION: A 60-year-old Tunisian man with recurrent abdominopelvic DFS for which he had undergone multiple excisions presented with an extensive DFS that invaded the external genitals. He underwent a large excision with emasculation and thin cutaneous graft of the abdominal wall and local skin flap in the pelvis. CONCLUSION: DFS is a rare yet recurrent skin tumor. Wide excision with free margins remains the cornerstone of treatment. We report a case of a giant DFS treated with wide excision and reconstructive surgery to cover the defect.
Subject(s)
Dermatofibrosarcoma , Skin Neoplasms , Abdomen/diagnostic imaging , Abdomen/surgery , Dermatofibrosarcoma/surgery , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Pelvis/diagnostic imaging , Pelvis/surgery , Skin Neoplasms/surgeryABSTRACT
We report a rare case of cytomegalovirus (CMV)-associated ischemic colitis and transverse myelitis (TM) occurring precociously after renal transplantation. A 57-year-old male was transplanted with a cadaveric kidney on 5 June 2009. The patient was CMV seropositive and the donor was seronegative. Transplantation was followed shortly by TM, which resulted in paraplegia. The results of magnetic resonance imaging of the spinal cord showed abnormalities. Twenty days after transplantation, he developed abdominal pain with melena and was diagnosed as having CMV-associated ischemic colitis confirmed by colonoscopy and biopsy. Serological data and identification of the viral genome by polymerase chain reaction were confirmatory for CMV. Treatment consisted of intravenous ganciclovir, followed by polyvalent immunoglobulin. The outcome was favorable. Symptomatic CMV infection is relatively common among the renal transplant population. Early colonoscopy is beneficial for making a quick diagnosis and therefore helps to institute a prompt management of CMV colitis. Myelitis is less common in transplant recipients and diagnosis, therefore, was more difficult.
Subject(s)
Colitis, Ischemic/etiology , Cytomegalovirus Infections/etiology , Kidney Transplantation/adverse effects , Myelitis, Transverse/etiology , Abdominal Pain/etiology , Antiviral Agents/therapeutic use , Biopsy , Colitis, Ischemic/diagnosis , Colitis, Ischemic/drug therapy , Colitis, Ischemic/virology , Colonoscopy , Cytomegalovirus/genetics , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Infections/drug therapy , Cytomegalovirus Infections/virology , DNA, Viral/analysis , Ganciclovir/therapeutic use , Humans , Immunoglobulins, Intravenous/therapeutic use , Immunologic Factors/therapeutic use , Magnetic Resonance Imaging , Male , Melena/etiology , Middle Aged , Myelitis, Transverse/diagnosis , Myelitis, Transverse/drug therapy , Myelitis, Transverse/virology , Polymerase Chain Reaction , Predictive Value of Tests , Treatment OutcomeABSTRACT
This study investigated the chemical composition (by using gas chromatography/flame ionization detection and gas chromatography/mass spectrometry, an antioxidant [1,1-diphenyl-2-picrylhydrazyl] [DPPH] radical-scavenging assay, and a 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonate [ABTS] radical cation-scavenging assay) and the antimalarial and cytotoxic activities of essential oil extracted from leaves of Melaleuca armillaris. Thirty-two components representing more than 98% of the total composition of the essential oil were identified. The main components were 1,8-cineole (85.8%), camphene (5.05%), and α-pinene (1.95%). The antioxidant activity by ABTS assay showed a mean (± standard deviation) 50% inhibitory concentration (IC(50)) value of 247.3 ± 3.9 mg/L, and the DPPH assay yielded an IC(50) value of 2183.6 ± 44.3 mg/L. The antimalarial study indicated that the essential oil had mild activity against the chloroquine-resistant Plasmodium falciparum FcB1 strain (IC(50), 27 ± 2 mg/L). The cytotoxic activity of this essential oil was tested against MCF7 human breast cancer cells and was found to be high (IC(50), 12 ± 1 mg/L).
