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Prim Care Diabetes ; 14(1): 47-52, 2020 02.
Article in English | MEDLINE | ID: mdl-31153799

ABSTRACT

The aim of this study was to investigate the role of Sudoscan asymmetry parameters in the diabetic foot. PATIENTS AND METHODS: In this study we included 165 participants: 84 type 2 diabetes patients divided into three HbA1c matched groups - group 1: newly diagnosed diabetics (n = 31), group 2: people with longer diabetes duration and established neuropathy (n = 33), group 3: patients with diabetic foot ulcer (n = 20), and a control group of 81 people with prediabetes. All subjects underwent peripheral sudomotor evaluation using Sudoscan device (Impeto Medical, Paris). RESULTS: Patients with diabetic foot had significantly higher Sudoscan feet asymmetry (19.6%) compared to those with only diabetic neuropathy (7.9%), compared to the group with newly diagnosed diabetes (7.44%), and compared to controls (2.5%). This test has shown a good discriminative value (with a threshold of 9.5%) for diabetic foot with area under the ROC curve of 0.955 (p = 0.001). Additionally, in a regression model feet asymmetry proved its predictive value for participants with diabetic foot. CONCLUSION: In this study Sudoscan feet asymmetry proved to be a novel discriminator and predictor for diabetic foot patients. It might be considered as a marker for early damage in the neuropathy evaluation protocol.


Subject(s)
Diabetes Mellitus, Type 2/complications , Diabetic Foot/diagnosis , Diabetic Neuropathies/diagnosis , Neurologic Examination , Skin/innervation , Sweating , Adult , Aged , Biomarkers/blood , Cross-Sectional Studies , Diabetes Mellitus, Type 2/blood , Diabetic Foot/etiology , Diabetic Foot/physiopathology , Diabetic Neuropathies/etiology , Diabetic Neuropathies/physiopathology , Early Diagnosis , Female , Foot , Glycated Hemoglobin/metabolism , Hand , Humans , Male , Middle Aged , Predictive Value of Tests
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