ABSTRACT
Desmoid tumors (DTs) are rare, aggressive malignancies developing from clonal fibroblastic proliferation originating from soft tissues. Despite their low metastatic potential, their invasiveness towards neighboring organs and a high recurrence rate contribute significantly to morbidity and mortality, thereby impacting the quality of life of patients. Several therapeutic options are available, but standardized protocols are lacking. In this study, we reviewed 14 cases of DT retrospectively over a period of 15 years, from September 2008 to December 2023. The most prevalent tumor locations were in the extremities, and the majority of patients were female. We identified risk factors in two patients, those being surgical trauma and familial adenomatous polyposis (FAP). Half of the patients underwent surgery for DT, and two received salvage radiotherapy. Systemic therapy was used in the first and second lines and comprised of chemotherapy, endocrine therapy, and non-steroidal anti-inflammatory drugs (NSAI). Active surveillance was proposed in three patients. This is the first retrospective study to assess the characteristics of DT in Moroccan patients in a tertiary care setting. It aims to shed light on the challenges faced in treating these rare tumors in the context of a lack of therapeutic standardization.
ABSTRACT
INTRODUCTION: Primary laryngeal lymphomas are exceedingly rare. Only about a hundred cases have been reported. They consist mainly of non-Hodgkin lymphoma, especially of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue. We report the first case of a primary laryngeal mantle cell lymphoma. CASE PRESENTATION: We report a case of a primary mantle cell lymphoma of the larynx in a 70-year-old North African non-smoker male. We present a detailed report of his clinical and paraclinical data as well as treatment options. CONCLUSIONS: Mantle cell lymphoma is a very aggressive lymphoma subset associated with poor prognosis. Laryngeal mantle cell lymphoma is exceedingly rare. To the best of our knowledge, this is the first case to ever be reported.
Subject(s)
Adenocarcinoma/surgery , Esophageal Neoplasms/surgery , Esophagogastric Junction/surgery , Stomach Neoplasms/surgery , Adenocarcinoma/pathology , Adult , Aged , Aged, 80 and over , Esophageal Neoplasms/pathology , Esophagectomy/methods , Esophagogastric Junction/pathology , Female , Gastrectomy/methods , Hospitals, University , Humans , Male , Middle Aged , Morocco , Retrospective Studies , Stomach Neoplasms/pathology , Treatment Outcome , Young AdultABSTRACT
Introduction: L'incidence du cancer de la Jonction oesogastrique (JOG) ne cesse d'augmenter depuis les deux dernieres decades aussi bien dans les pays industrialises que dans les pays en voie dedeveloppement notamment le Maroc. Le rapprochement sur le plan etiopathogenique desadenocarcinomes (ADK) du cardia et ceux du bas oesophage reste un sujet de controverse posant leprobleme du choix therapeutique chirurgical; notamment l'etendu de la resection. Le but de ce travail est de dresser le profil epidemiologique des patients operes pour un ADK du cardia et analyser les gesteschirurgicaux realises par l'equipe chirurgicale A du centre hospitalier universitaire IBN SINA a Rabat atravers une serie de 149 cas. Methodes: Il s'agit d'une etude retrospective ayant interesse les malades operes pour un ADK de la JOG sur une periode de 15 annees (1990-2004) en chirurgie A du CHU IBNSINA a Rabat. Resultats: 149 cas d'ADK de la JOG ont ete retenus. L'age moyen etait de 55 ans; 76etaient de sexe masculin avec un sex-ratio de 3/1. Les signes cliniques les plus frequemment observessont la dysphagie (70); les douleurs epigastriques (67) et le reflux gastro-oesophagien (15.5). La notion de tabagisme n'a ete rapportee que chez 20des cas et l'oesophage de barret chez 10des patients. Le type I de Siewert a concerne 65 cas (43.5); le type II 40 cas (27); et le type III 44 cas (29.5). Dans le type I une oesophagectomie transhiatale a ete proposee; alors que les type II et III ont ete traite comme un cancer de l'estomac par une gastrectomie totale. Les suites operatoires etaient simples chez 80des patients; la mortalite globale etait de 8.5. Conclusion: L'oesophagectomie par voie transhiatale chez les patients fragiles avec un ADK de la JOG de type I permet des resultats carcinologiques satisfaisants avec reduction de la morbidite postoperatoire par rapport a la voie transthoracique. La gastrectomie totale est le traitement de choix pour les types III; alors que le debat est toujours ouvert quant a la meilleure strategie chirurgicale pour la prise en charge des tumeurs de type II
Subject(s)
Adenocarcinoma/surgery , Case Reports , Esophagogastric JunctionABSTRACT
BACKGROUND: Germ cell tumours are uncommon in aged man. We present a rare case of metastatic seminoma of the testis associated with liver and renal insufficiencies in a 78-years-old man managed successfully with carboplatin based chemotherapy. CASE PRESENTATION: A 78 years old man admitted with signs and symptoms suggestive of a testicular cancer with alteration of health. Computed tomography of the pelvis and abdomen showed a large retroperitoneal tumour. The diagnosis of seminoma was established from the histological study of the left orchidectomy. At admission, the liver and renal check-up showed liver and renal insufficiencies. CONCLUSION: The patient received 4 of carboplatin based chemotherapy with significant improvement in symptoms, and complete radiological response.
