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1.
Sci Rep ; 13(1): 11000, 2023 07 07.
Article in English | MEDLINE | ID: mdl-37419881

ABSTRACT

Designing efficient and labor-saving prosthetic hands requires powerful hand gesture recognition algorithms that can achieve high accuracy with limited complexity and latency. In this context, the paper proposes a Compact Transformer-based Hand Gesture Recognition framework referred to as [Formula: see text], which employs a vision transformer network to conduct hand gesture recognition using high-density surface EMG (HD-sEMG) signals. Taking advantage of the attention mechanism, which is incorporated into the transformer architectures, our proposed [Formula: see text] framework overcomes major constraints associated with most of the existing deep learning models such as model complexity; requiring feature engineering; inability to consider both temporal and spatial information of HD-sEMG signals, and requiring a large number of training samples. The attention mechanism in the proposed model identifies similarities among different data segments with a greater capacity for parallel computations and addresses the memory limitation problems while dealing with inputs of large sequence lengths. [Formula: see text] can be trained from scratch without any need for transfer learning and can simultaneously extract both temporal and spatial features of HD-sEMG data. Additionally, the [Formula: see text] framework can perform instantaneous recognition using sEMG image spatially composed from HD-sEMG signals. A variant of the [Formula: see text] is also designed to incorporate microscopic neural drive information in the form of Motor Unit Spike Trains (MUSTs) extracted from HD-sEMG signals using Blind Source Separation (BSS). This variant is combined with its baseline version via a hybrid architecture to evaluate potentials of fusing macroscopic and microscopic neural drive information. The utilized HD-sEMG dataset involves 128 electrodes that collect the signals related to 65 isometric hand gestures of 20 subjects. The proposed [Formula: see text] framework is applied to 31.25, 62.5, 125, 250 ms window sizes of the above-mentioned dataset utilizing 32, 64, 128 electrode channels. Our results are obtained via 5-fold cross-validation by first applying the proposed framework on the dataset of each subject separately and then, averaging the accuracies among all the subjects. The average accuracy over all the participants using 32 electrodes and a window size of 31.25 ms is 86.23%, which gradually increases till reaching 91.98% for 128 electrodes and a window size of 250 ms. The [Formula: see text] achieves accuracy of 89.13% for instantaneous recognition based on a single frame of HD-sEMG image. The proposed model is statistically compared with a 3D Convolutional Neural Network (CNN) and two different variants of Support Vector Machine (SVM) and Linear Discriminant Analysis (LDA) models. The accuracy results for each of the above-mentioned models are paired with their precision, recall, F1 score, required memory, and train/test times. The results corroborate effectiveness of the proposed [Formula: see text] framework compared to its counterparts.


Subject(s)
Gestures , Neural Networks, Computer , Humans , Algorithms , Electromyography/methods , Recognition, Psychology , Hand
2.
PLoS One ; 18(3): e0282121, 2023.
Article in English | MEDLINE | ID: mdl-36862633

ABSTRACT

The main objective of this study is to develop a robust deep learning-based framework to distinguish COVID-19, Community-Acquired Pneumonia (CAP), and Normal cases based on volumetric chest CT scans, which are acquired in different imaging centers using different scanners and technical settings. We demonstrated that while our proposed model is trained on a relatively small dataset acquired from only one imaging center using a specific scanning protocol, it performs well on heterogeneous test sets obtained by multiple scanners using different technical parameters. We also showed that the model can be updated via an unsupervised approach to cope with the data shift between the train and test sets and enhance the robustness of the model upon receiving a new external dataset from a different center. More specifically, we extracted the subset of the test images for which the model generated a confident prediction and used the extracted subset along with the training set to retrain and update the benchmark model (the model trained on the initial train set). Finally, we adopted an ensemble architecture to aggregate the predictions from multiple versions of the model. For initial training and development purposes, an in-house dataset of 171 COVID-19, 60 CAP, and 76 Normal cases was used, which contained volumetric CT scans acquired from one imaging center using a single scanning protocol and standard radiation dose. To evaluate the model, we collected four different test sets retrospectively to investigate the effects of the shifts in the data characteristics on the model's performance. Among the test cases, there were CT scans with similar characteristics as the train set as well as noisy low-dose and ultra-low-dose CT scans. In addition, some test CT scans were obtained from patients with a history of cardiovascular diseases or surgeries. This dataset is referred to as the "SPGC-COVID" dataset. The entire test dataset used in this study contains 51 COVID-19, 28 CAP, and 51 Normal cases. Experimental results indicate that our proposed framework performs well on all test sets achieving total accuracy of 96.15% (95%CI: [91.25-98.74]), COVID-19 sensitivity of 96.08% (95%CI: [86.54-99.5]), CAP sensitivity of 92.86% (95%CI: [76.50-99.19]), Normal sensitivity of 98.04% (95%CI: [89.55-99.95]) while the confidence intervals are obtained using the significance level of 0.05. The obtained AUC values (One class vs Others) are 0.993 (95%CI: [0.977-1]), 0.989 (95%CI: [0.962-1]), and 0.990 (95%CI: [0.971-1]) for COVID-19, CAP, and Normal classes, respectively. The experimental results also demonstrate the capability of the proposed unsupervised enhancement approach in improving the performance and robustness of the model when being evaluated on varied external test sets.


Subject(s)
COVID-19 , Humans , COVID-19/diagnostic imaging , Retrospective Studies , Tomography, X-Ray Computed , Cone-Beam Computed Tomography , Benchmarking
3.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 5115-5119, 2022 07.
Article in English | MEDLINE | ID: mdl-36086242

ABSTRACT

Recently, there has been a surge of significant interest on application of Deep Learning (DL) models to autonomously perform hand gesture recognition using surface Electromyogram (sEMG) signals. Many of the existing DL models are, however, designed to be applied on sparse sEMG signals. Furthermore, due to the complex structure of these models, typically, we are faced with memory constraint issues, require large training times and a large number of training samples, and; there is the need to resort to data augmentation and/or transfer learning. In this paper, for the first time (to the best of our knowledge), we investigate and design a Vision Transformer (ViT) based architecture to perform hand gesture recognition from High Density (HD-sEMG) signals. Intuitively speaking, we capitalize on the recent breakthrough role of the transformer architecture in tackling different com-plex problems together with its potential for employing more input parallelization via its attention mechanism. The proposed Vision Transformer-based Hand Gesture Recognition (ViT-HGR) framework can overcome the aforementioned training time problems and can accurately classify a large number of hand gestures from scratch without any need for data augmentation and/or transfer learning. The efficiency of the proposed ViT-HGR framework is evaluated using a recently-released HD-sEMG dataset consisting of 65 isometric hand gestures. Our experiments with 64-sample (31.25 ms) window size yield average test accuracy of 84.62 ± 3.07%, where only 78,210 learnable parameters are utilized in the model. The compact structure of the proposed ViT-based ViT-HGR framework (i.e., having significantly reduced number of trainable parameters) shows great potentials for its practical application for prosthetic control.


Subject(s)
Gestures , Pattern Recognition, Automated , Electric Power Supplies , Electromyography , Signal Processing, Computer-Assisted
4.
Sci Rep ; 12(1): 4827, 2022 03 22.
Article in English | MEDLINE | ID: mdl-35318368

ABSTRACT

Reverse transcription-polymerase chain reaction is currently the gold standard in COVID-19 diagnosis. It can, however, take days to provide the diagnosis, and false negative rate is relatively high. Imaging, in particular chest computed tomography (CT), can assist with diagnosis and assessment of this disease. Nevertheless, it is shown that standard dose CT scan gives significant radiation burden to patients, especially those in need of multiple scans. In this study, we consider low-dose and ultra-low-dose (LDCT and ULDCT) scan protocols that reduce the radiation exposure close to that of a single X-ray, while maintaining an acceptable resolution for diagnosis purposes. Since thoracic radiology expertise may not be widely available during the pandemic, we develop an Artificial Intelligence (AI)-based framework using a collected dataset of LDCT/ULDCT scans, to study the hypothesis that the AI model can provide human-level performance. The AI model uses a two stage capsule network architecture and can rapidly classify COVID-19, community acquired pneumonia (CAP), and normal cases, using LDCT/ULDCT scans. Based on a cross validation, the AI model achieves COVID-19 sensitivity of [Formula: see text], CAP sensitivity of [Formula: see text], normal cases sensitivity (specificity) of [Formula: see text], and accuracy of [Formula: see text]. By incorporating clinical data (demographic and symptoms), the performance further improves to COVID-19 sensitivity of [Formula: see text], CAP sensitivity of [Formula: see text], normal cases sensitivity (specificity) of [Formula: see text] , and accuracy of [Formula: see text]. The proposed AI model achieves human-level diagnosis based on the LDCT/ULDCT scans with reduced radiation exposure. We believe that the proposed AI model has the potential to assist the radiologists to accurately and promptly diagnose COVID-19 infection and help control the transmission chain during the pandemic.


Subject(s)
Artificial Intelligence , COVID-19 , COVID-19/diagnostic imaging , COVID-19 Testing , Humans , Radionuclide Imaging , Tomography, X-Ray Computed
5.
Sci Rep ; 12(1): 3212, 2022 02 25.
Article in English | MEDLINE | ID: mdl-35217712

ABSTRACT

Novel Coronavirus disease (COVID-19) is a highly contagious respiratory infection that has had devastating effects on the world. Recently, new COVID-19 variants are emerging making the situation more challenging and threatening. Evaluation and quantification of COVID-19 lung abnormalities based on chest Computed Tomography (CT) images can help determining the disease stage, efficiently allocating limited healthcare resources, and making informed treatment decisions. During pandemic era, however, visual assessment and quantification of COVID-19 lung lesions by expert radiologists become expensive and prone to error, which raises an urgent quest to develop practical autonomous solutions. In this context, first, the paper introduces an open-access COVID-19 CT segmentation dataset containing 433 CT images from 82 patients that have been annotated by an expert radiologist. Second, a Deep Neural Network (DNN)-based framework is proposed, referred to as the [Formula: see text], that autonomously segments lung abnormalities associated with COVID-19 from chest CT images. Performance of the proposed [Formula: see text] framework is evaluated through several experiments based on the introduced and external datasets. Third, an unsupervised enhancement approach is introduced that can reduce the gap between the training set and test set and improve the model generalization. The enhanced results show a dice score of 0.8069 and specificity and sensitivity of 0.9969 and 0.8354, respectively. Furthermore, the results indicate that the [Formula: see text] model can efficiently segment COVID-19 lesions in both 2D CT images and whole lung volumes. Results on the external dataset illustrate generalization capabilities of the [Formula: see text] model to CT images obtained from a different scanner.


Subject(s)
COVID-19/diagnostic imaging , Image Processing, Computer-Assisted/methods , Neural Networks, Computer , Radiography, Thoracic , Tomography, X-Ray Computed , Datasets as Topic , Female , Humans , Male , Middle Aged
6.
Expert Syst Appl ; 187: 115879, 2022 Jan.
Article in English | MEDLINE | ID: mdl-34566272

ABSTRACT

The novel of coronavirus (COVID-19) has suddenly and abruptly changed the world as we knew at the start of the 3rd decade of the 21st century. Particularly, COVID-19 pandemic has negatively affected financial econometrics and stock markets across the globe. Artificial Intelligence (AI) and Machine Learning (ML)-based prediction models, especially Deep Neural Network (DNN) architectures, have the potential to act as a key enabling factor to reduce the adverse effects of the COVID-19 pandemic and future possible ones on financial markets. In this regard, first, a unique COVID-19 related PRIce MOvement prediction ( COVID19 PRIMO ) dataset is introduced in this paper, which incorporates effects of social media trends related to COVID-19 on stock market price movements. Afterwards, a novel hybrid and parallel DNN-based framework is proposed that integrates different and diversified learning architectures. Referred to as the COVID-19 adopted Hybrid and Parallel deep fusion framework for Stock price Movement Prediction ( COVID19-HPSMP ), innovative fusion strategies are used to combine scattered social media news related to COVID-19 with historical mark data. The proposed COVID19-HPSMP consists of two parallel paths (hence hybrid), one based on Convolutional Neural Network (CNN) with Local/Global Attention modules, and one integrated CNN and Bi-directional Long Short term Memory (BLSTM) path. The two parallel paths are followed by a multilayer fusion layer acting as a fusion center that combines localized features. Performance evaluations are performed based on the introduced COVID19 PRIMO dataset illustrating superior performance of the proposed framework.

7.
Front Artif Intell ; 4: 598932, 2021.
Article in English | MEDLINE | ID: mdl-34113843

ABSTRACT

The newly discovered Coronavirus Disease 2019 (COVID-19) has been globally spreading and causing hundreds of thousands of deaths around the world as of its first emergence in late 2019. The rapid outbreak of this disease has overwhelmed health care infrastructures and arises the need to allocate medical equipment and resources more efficiently. The early diagnosis of this disease will lead to the rapid separation of COVID-19 and non-COVID cases, which will be helpful for health care authorities to optimize resource allocation plans and early prevention of the disease. In this regard, a growing number of studies are investigating the capability of deep learning for early diagnosis of COVID-19. Computed tomography (CT) scans have shown distinctive features and higher sensitivity compared to other diagnostic tests, in particular the current gold standard, i.e., the Reverse Transcription Polymerase Chain Reaction (RT-PCR) test. Current deep learning-based algorithms are mainly developed based on Convolutional Neural Networks (CNNs) to identify COVID-19 pneumonia cases. CNNs, however, require extensive data augmentation and large datasets to identify detailed spatial relations between image instances. Furthermore, existing algorithms utilizing CT scans, either extend slice-level predictions to patient-level ones using a simple thresholding mechanism or rely on a sophisticated infection segmentation to identify the disease. In this paper, we propose a two-stage fully automated CT-based framework for identification of COVID-19 positive cases referred to as the "COVID-FACT". COVID-FACT utilizes Capsule Networks, as its main building blocks and is, therefore, capable of capturing spatial information. In particular, to make the proposed COVID-FACT independent from sophisticated segmentations of the area of infection, slices demonstrating infection are detected at the first stage and the second stage is responsible for classifying patients into COVID and non-COVID cases. COVID-FACT detects slices with infection, and identifies positive COVID-19 cases using an in-house CT scan dataset, containing COVID-19, community acquired pneumonia, and normal cases. Based on our experiments, COVID-FACT achieves an accuracy of 90.82 % , a sensitivity of 94.55 % , a specificity of 86.04 % , and an Area Under the Curve (AUC) of 0.98, while depending on far less supervision and annotation, in comparison to its counterparts.

8.
Sci Data ; 8(1): 121, 2021 04 29.
Article in English | MEDLINE | ID: mdl-33927208

ABSTRACT

Novel Coronavirus (COVID-19) has drastically overwhelmed more than 200 countries affecting millions and claiming almost 2 million lives, since its emergence in late 2019. This highly contagious disease can easily spread, and if not controlled in a timely fashion, can rapidly incapacitate healthcare systems. The current standard diagnosis method, the Reverse Transcription Polymerase Chain Reaction (RT- PCR), is time consuming, and subject to low sensitivity. Chest Radiograph (CXR), the first imaging modality to be used, is readily available and gives immediate results. However, it has notoriously lower sensitivity than Computed Tomography (CT), which can be used efficiently to complement other diagnostic methods. This paper introduces a new COVID-19 CT scan dataset, referred to as COVID-CT-MD, consisting of not only COVID-19 cases, but also healthy and participants infected by Community Acquired Pneumonia (CAP). COVID-CT-MD dataset, which is accompanied with lobe-level, slice-level and patient-level labels, has the potential to facilitate the COVID-19 research, in particular COVID-CT-MD can assist in development of advanced Machine Learning (ML) and Deep Neural Network (DNN) based solutions.


Subject(s)
COVID-19/diagnostic imaging , Deep Learning , Tomography, X-Ray Computed , Adult , Aged , Female , Humans , Machine Learning , Male , Middle Aged , Neural Networks, Computer
9.
Pattern Recognit Lett ; 138: 638-643, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32958971

ABSTRACT

Novel Coronavirus disease (COVID-19) has abruptly and undoubtedly changed the world as we know it at the end of the 2nd decade of the 21st century. COVID-19 is extremely contagious and quickly spreading globally making its early diagnosis of paramount importance. Early diagnosis of COVID-19 enables health care professionals and government authorities to break the chain of transition and flatten the epidemic curve. The common type of COVID-19 diagnosis test, however, requires specific equipment and has relatively low sensitivity. Computed tomography (CT) scans and X-ray images, on the other hand, reveal specific manifestations associated with this disease. Overlap with other lung infections makes human-centered diagnosis of COVID-19 challenging. Consequently, there has been an urgent surge of interest to develop Deep Neural Network (DNN)-based diagnosis solutions, mainly based on Convolutional Neural Networks (CNNs), to facilitate identification of positive COVID-19 cases. CNNs, however, are prone to lose spatial information between image instances and require large datasets. The paper presents an alternative modeling framework based on Capsule Networks, referred to as the COVID-CAPS, being capable of handling small datasets, which is of significant importance due to sudden and rapid emergence of COVID-19. Our results based on a dataset of X-ray images show that COVID-CAPS has advantage over previous CNN-based models. COVID-CAPS achieved an Accuracy of 95.7%, Sensitivity of 90%, Specificity of 95.8%, and Area Under the Curve (AUC) of 0.97, while having far less number of trainable parameters in comparison to its counterparts. To potentially and further improve diagnosis capabilities of the COVID-CAPS, pre-training and transfer learning are utilized based on a new dataset constructed from an external dataset of X-ray images. This is in contrary to existing works on COVID-19 detection where pre-training is performed based on natural images. Pre-training with a dataset of similar nature further improved accuracy to 98.3% and specificity to 98.6%.

10.
Sci Rep ; 10(1): 7948, 2020 05 14.
Article in English | MEDLINE | ID: mdl-32409715

ABSTRACT

Despite the advances in automatic lung cancer malignancy prediction, achieving high accuracy remains challenging. Existing solutions are mostly based on Convolutional Neural Networks (CNNs), which require a large amount of training data. Most of the developed CNN models are based only on the main nodule region, without considering the surrounding tissues. Obtaining high sensitivity is challenging with lung nodule malignancy prediction. Moreover, the interpretability of the proposed techniques should be a consideration when the end goal is to utilize the model in a clinical setting. Capsule networks (CapsNets) are new and revolutionary machine learning architectures proposed to overcome shortcomings of CNNs. Capitalizing on the success of CapsNet in biomedical domains, we propose a novel model for lung tumor malignancy prediction. The proposed framework, referred to as the 3D Multi-scale Capsule Network (3D-MCN), is uniquely designed to benefit from: (i) 3D inputs, providing information about the nodule in 3D; (ii) Multi-scale input, capturing the nodule's local features, as well as the characteristics of the surrounding tissues, and; (iii) CapsNet-based design, being capable of dealing with a small number of training samples. The proposed 3D-MCN architecture predicted lung nodule malignancy with a high accuracy of 93.12%, sensitivity of 94.94%, area under the curve (AUC) of 0.9641, and specificity of 90% when tested on the LIDC-IDRI dataset. When classifying patients as having a malignant condition (i.e., at least one malignant nodule is detected) or not, the proposed model achieved an accuracy of 83%, and a sensitivity and specificity of 84% and 81% respectively.


Subject(s)
Computational Biology , Lung Neoplasms/diagnosis , Neural Networks, Computer , Humans
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