ABSTRACT
A study of adrenal mineral corticoid function in adolescents with primary arterial hypertension, stage Ib, revealed hyperaldosteronism in more than half of the patients (57%). Treatment with beta-blocking agents (anaprilin and obsidan) was only effective (producing a drop in arterial pressure) in patients with initial high plasma aldosterone levels. beta-blocking agents administered to patients with normal blood aldosterone content did not result in arterial pressure change (failure of treatment). The results obtained suggest that the effect of beta-blocking agents on adrenal mineral corticoid activity in adolescent patients with primary arterial hypertension depends on its baseline level; they are also indicative of a dependence of the hypotensive effect of beta-adrenoreceptor blockers on the state of mineral corticoid function.
Subject(s)
Adrenal Cortex/physiopathology , Adrenergic beta-Antagonists/administration & dosage , Aldosterone/blood , Hypertension/physiopathology , Administration, Oral , Adolescent , Aerosols , Aldosterone/urine , Child , Humans , Hydrocortisone/blood , Hypertension/drug therapySubject(s)
Blood Pressure , Hypertension/physiopathology , International Cooperation , Adolescent , Anthropometry , Cuba , Electrocardiography , Europe, Eastern , Female , Humans , Male , Prospective Studies , Research , Sexual Maturation , USSRSubject(s)
Autonomic Nervous System Diseases/complications , Hypertension/complications , Vascular Headaches/etiology , Adolescent , Adrenal Gland Neoplasms/complications , Brain Diseases/diagnosis , Child , Diagnosis, Differential , Humans , Hypothalamic Diseases/complications , Intracranial Pressure , Migraine Disorders/diagnosis , Pheochromocytoma/complications , PubertySubject(s)
Cardiomegaly/diagnosis , Adolescent , Cardiomegaly/drug therapy , Cardiomyopathy, Hypertrophic/diagnosis , Cardiomyopathy, Hypertrophic/drug therapy , Cardiomyopathy, Hypertrophic/genetics , Child , Child, Preschool , Diagnosis, Differential , Echocardiography , Electrocardiography , Female , Humans , MaleABSTRACT
In 1977 in the cooperating centres (Moscow, Budapest, Berlin, Habana) 17,628 schoolchildren born in 1964, were examined, and a group was distinguished with increased BP (1862 children) and 10% random samples of the examined schoolchildren with normal BP. All the parents of the examined schoolchildren, including grandparents, were mailed questionnaire which concerned the family anamnesis, in particular, cases of cardiovascular diseases. The mailed questionnaires were answered by 74% of parents which permits one to judge about a high authenticity of the obtained results. The analysis of the results obtained by that questionnaire affirmed a higher incidence of cardiovascular diseases found in relatives of the children with increased BP than in relatives of the children with normal BP.
Subject(s)
Blood Pressure , Hypertension/genetics , Adolescent , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/genetics , Child , Cuba , Female , Germany, East , Humans , Hungary , Hypertension/epidemiology , International Cooperation , Male , Surveys and Questionnaires , USSRSubject(s)
Blood Pressure , International Cooperation , Urban Population , Adolescent , Age Factors , Berlin , Child , Cuba , Female , Humans , Hungary , Lithuania , Male , Menstruation , Moscow , Sex FactorsSubject(s)
Hypertension/diagnosis , Adolescent , Blood Pressure , Child , Female , Hemodynamics , Humans , Hypertension/physiopathology , Hypertension/therapy , Male , Prognosis , Prostaglandins/physiologySubject(s)
Adrenergic beta-Antagonists/therapeutic use , Cardiovascular System/drug effects , Hypertension/drug therapy , Adolescent , Blood Pressure/drug effects , Child , Child, Preschool , Drug Evaluation , Humans , Myocardial Contraction/drug effects , Propranolol/therapeutic use , Pulse/drug effects , Time Factors , USSRSubject(s)
Arrhythmia, Sinus/diagnosis , Electrocardiography , Syncope/diagnosis , Adult , Arrhythmia, Sinus/genetics , Child , Deafness/congenital , Female , Humans , Syncope/genetics , SyndromeABSTRACT
The condition of the sympatheticoadrenal system and blood renin activity were studied in healthy children and in children suffering from primary arterial hypertension and treated with beta-blocking agents (Obzidan, Visken). A hypotensive effect was noted in the group of patients suffering from primary arterial hypertension with a high blood renin level and increased excretion of catecholamines in the urine.
