ABSTRACT
For 32 eyes tested for glare disability after undergoing extracapsular cataract extraction with implantation of posterior chamber intraocular lenses, the mean contrast threshold in the presence of the glare source was 23% for undilated pupils and 31% with dilation. A regression analysis of glare scores as a function of the amount of posterior capsule opacification showed a significant (P less than .00001) association between the two.
Subject(s)
Lenses, Intraocular , Vision Disorders/diagnosis , Aged , Female , Humans , MaleABSTRACT
Several large United States data sources were examined to determine the trend in cataract surgery for the eight-year period 1968--1976. Age-stratified rates of intracapsular cataract extractions were calculated to control for changes in the age structure of the population. Cataract extractions increased steadily at the rate of 4.2% per year. A number of medical, social, and economic factors appear to be involved in this increase. The relative contribution of some of these factors was determined through examination of data related to hospitalizations for cataracts and the availability of ophthalmic services. Additionally, the increasing demand for better vision among the elderly was estimated by examining the increase of drivers' licenses in force for this period.
Subject(s)
Cataract Extraction/trends , Adult , Age Factors , Aged , Automobile Driving , Cataract Extraction/methods , Epidemiology , Humans , Length of Stay , Middle Aged , Ophthalmology , Patient Discharge , Sampling Studies , Sex Factors , United States , WorkforceABSTRACT
Pancreatic acinar cells undergo degeneration or necrosis following injection of puromycin intraperitoneally in rats. The purpose of this study was to characterize recovery following injection of four hourly doses of puromycin, 40mg/kg of body weight, examining the pancreas histologically and by electron microscopy. The number of dividing acinar cells increased following injury. By 12 to 24 hours following treatment, electron microscopy showed numerous autophagic vacuoles and intracisternal granules in the cells. By 48 hours, these were largely cleared from surviving cells although the intracisternal granules persisted in isolated acinar cells as long as 144 hours. At 24 hours, there was debris in the acinar lumens and interstitial space. We conclude that some acinar cells injured by puromycin may survive and be restored to normal structure; that surviving acinar cells can extrude autophagic vacuoles; and that necrotic acinar cells are replaced by regeneration following puromycin-induced injury in rats.
