A new lexical card-sorting task for studying fronto-striatal contribution to processing language rules.

The role of fronto-striatal regions in processing different language rules such as semantic and (grapho) phonological ones is still under debate. We have recently developed a lexical analog of the Wisconsin card sorting task which measures set-shifting abilities where the visual rules color, number, shape were replaced by three language ones: semantic, rhyme and syllable onset (attack). In the present study we aimed to compare fronto-striatal activations between the different lexical rules that are required for matching the test words to the response ones. Using functional magnetic resonance imaging (fMRI), fourteen healthy, native French-speaking participants were scanned. The results showed that some regions within the brain language network are differentially involved in semantic and phonological processes. Semantic decisions activated significantly the ventrolateral prefrontal cortex, the dorsolateral prefrontal cortex, the fusiform gyrus, the ventral temporal lobe and the caudate nucleus, while phonological decisions produced significant activation in posterior Broca's area (area 44), the temporoparietal junction and motor cortical regions. These findings provide critical support for the existence of a ventral subcortical semantic pathway and a more dorsal phonological stream as proposed by Duffau, Leroy, and Gatignol (2008). Furthermore, we propose that the strong involvement of area 47/12 of the ventrolateral prefrontal cortex and caudate nucleus observed in semantic processing, is not specific to language, but to the fact that a category or a rule has to be retrieved amongst competing ones in memory, similarly to what is observed when planning a set-shift in the original (non-lexical) version of the Wisconsin card sorting task.

Cerebral atrophy and its relation to cognitive impairment in Parkinson disease.

OBJECTIVE: Voxel-based morphometry was used to compare the amounts of gray matter in the brains of patients with Parkinson disease (PD) and normal control subjects (NCs) and to identify the specific regions responsible for cognitive dysfunction in PD. METHODS: Patients were classified into nondemented (ND) and demented (D) groups according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (4th ed.), and a group comparison was performed. In the ND patients, a correlation was also performed between local gray matter density and the score on Raven Colored Progressive Matrices (RCPM), a test of executive and visuospatial function. RESULTS: In patients with advanced ND-PD vs NCs, atrophic changes were observed in the limbic/paralimbic areas and the prefrontal cortex. In D vs ND patients, atrophic change was observed widely in the limbic/paralimbic system, including the anterior cingulate gyrus and hippocampus as well as the temporal lobe, dorsolateral prefrontal cortex, thalamus, and caudate nucleus. The RCPM score was positively correlated with the gray matter density in the dorsolateral prefrontal cortex and the parahippocampal gyrus. CONCLUSIONS: In patients with Parkinson disease (PD), atrophic changes occur mainly in the limbic/paralimbic and prefrontal areas. These atrophic changes may be related to the development of dementia in PD.

High- and moderately high-methionine uptake demonstrated by PET in a patient with a subacute cerebral infarction.

In patients with cerebral tumors, high accumulations of L-methyl-11C-methionine (11C-Met) have been reported in some cases of cerebral ischemic disease, but no high accumulations of 11C-Met in areas where only transient arterial occlusions are most likely to occur have been reported. Herein we present a case of a high accumulation of 11C-Met in an area of frontal interhemispheric cerebral infarction and a moderately high accumulation with an unclear margin in a distant frontal convexity area. A craniotomy revealed a subacute stage of cerebral infarction in the interhemispheric lesion, and an ischemic change in the distant convexity area. Sixteen months after onset, CT scans demonstrated an infarction area in the interhemispheric lesion only, and no atrophic changes were observed in the distant convexity area indicating that no serious tissue damage had occurred.