1.
Bioorg Med Chem Lett
; 21(6): 1758-62, 2011 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-21316233
ABSTRACT
Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-ß inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.
Subject(s)
I-kappa B Kinase/antagonists & inhibitors , Indazoles/pharmacology , Protein Kinase Inhibitors/pharmacology , Animals , Mice
2.
Angew Chem Int Ed Engl
; 44(12): 1810-3, 2005 Mar 11.
Article
in English
| MEDLINE
| ID: mdl-15714451
3.
Chem Commun (Camb)
; (15): 1808-9, 2003 Aug 07.
Article
in English
| MEDLINE
| ID: mdl-12931977
ABSTRACT
Despite their structural similarity, triangular tetradentate ligands 2b and 2c experience different assembly pathways on complexation with (en)Pd(NO3)2 to give M8L4 tetrahedral (3) and open cone (4) structures, respectively, due to steric restriction by side chains at the corner or on the edge of the ligands.